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Entries
ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)
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authored
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
catalystActivity
[CatalystActivity:4086253] alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity of ST6GALNAC1-6 [Golgi membrane]
category
transition
compartment
[Compartment:20699] Golgi membrane
[Compartment:17963] Golgi lumen
created
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
dbId
4084980
displayName
ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)
edited
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
eventOf
[Pathway:R-HSA-4085001] Sialic acid metabolism - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane - Homo sapiens
input
[SimpleEntity:R-ALL-727815] CMP-Neu5Ac [Golgi lumen]
[SimpleEntity:R-ALL-4086301] GalNAc-R [Golgi lumen]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:4086254] Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens
[LiteratureReference:981812] Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells
[LiteratureReference:981829] Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV
[LiteratureReference:4086271] Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides
[LiteratureReference:4086333] Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)
orthologousEvent
[Reaction:R-GGA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Gallus gallus
[Reaction:R-XTR-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Xenopus tropicalis
[Reaction:R-DRE-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Danio rerio
[Reaction:R-SSC-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Sus scrofa
[Reaction:R-BTA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Bos taurus
[Reaction:R-CFA-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Canis familiaris
[Reaction:R-RNO-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Rattus norvegicus
[Reaction:R-MMU-4084980] ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link) - Mus musculus
output
[SimpleEntity:R-ALL-727810] CMP [Golgi lumen]
[SimpleEntity:R-ALL-4086341] Neu5Ac-2,6-GalNAc-R [Golgi lumen]
precedingEvent
[Reaction:R-HSA-727807] SLC35A1 exchanges CMP-Neu5Ac for CMP - Homo sapiens
releaseDate
2014年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014年01月08日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-4084980
summation
[Summation:4086299] The alpha-2,6-sialyltransferases 1-6 (ST6GALNAC1-6) are able...
Referrals
(hasEvent)
[Pathway:R-HSA-4085001] Sialic acid metabolism
(precedingEvent)
[BlackBoxEvent:R-HSA-4088207] Golgi lumen glycoconjugates translocate to the plasma membrane
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