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Schema
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Reaction
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Entries
NEU4 hydrolyses Neu5Ac from glycoconjugates
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authored
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
catalystActivity
[CatalystActivity:9638115] exo-alpha-sialidase activity of NEU4:GLB1:CTSA dimer [lysosomal lumen]
category
transition
compartment
[Compartment:161320] lysosomal lumen
created
[InstanceEdit:9638118] Jassal, Bijay, 2019年02月25日
dbId
9638120
displayName
NEU4 hydrolyses Neu5Ac from glycoconjugates
edited
[InstanceEdit:4085031] Jassal, Bijay, 2013年08月01日
eventOf
[Pathway:R-HSA-4085001] Sialic acid metabolism - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9840581] GM1 localizes to endosome membrane - Homo sapiens
input
[DefinedSet:R-ALL-4088213] glycoconjugates [lysosomal lumen]
[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1605674] A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable
[LiteratureReference:1605626] Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis
[LiteratureReference:1605657] Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases
[LiteratureReference:1605628] Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism
[LiteratureReference:4088089] Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family
[LiteratureReference:1605756] Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells
[LiteratureReference:5225585] Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
NEU4 hydrolyses Neu5Ac from glycoconjugates
orthologousEvent
[Reaction:R-GGA-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Gallus gallus
[Reaction:R-XTR-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Xenopus tropicalis
[Reaction:R-SSC-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Sus scrofa
[Reaction:R-BTA-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Bos taurus
[Reaction:R-CFA-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Canis familiaris
[Reaction:R-RNO-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Rattus norvegicus
[Reaction:R-MMU-9638120] NEU4 hydrolyses Neu5Ac from glycoconjugates - Mus musculus
output
[DefinedSet:R-ALL-4087987] Gal-R,GalNAc-R,Neu5Ac-R [lysosomal lumen]
[SimpleEntity:R-ALL-428639] Neu5Ac [lysosomal lumen]
releaseDate
2014年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5225590] Medrano, Juan F, Wickramasinghe, Saumya, 2014年01月08日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9638120
summation
[Summation:9638116] Sialidases 1-4 (NEU1-4, neuraminidases, receptor-destroying ...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-9840581] GM1 localizes to endosome membrane
(hasEvent)
[Pathway:R-HSA-4085001] Sialic acid metabolism
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