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Entries
Synthesis of Leukotrienes (LT) and Eoxins (EX)
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authored
[InstanceEdit:2142839] Williams, MG, 2012年02月24日
created
[InstanceEdit:2142724] Williams, MG, 2012年02月24日
crossReference
[DatabaseIdentifier:12757986] BioModels Database:BIOMD0000000106
dbId
2142691
deleted
[Deleted:5567296] Deletion of instance: 265309
displayName
Synthesis of Leukotrienes (LT) and Eoxins (EX)
edited
[InstanceEdit:2142839] Williams, MG, 2012年02月24日
eventOf
[Pathway:R-HSA-2142753] Arachidonate metabolism - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:9962] leukotriene metabolic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-429016] ALOX5 is phosphorylated by MAPKAP2 - Homo sapiens
[Reaction:R-HSA-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Homo sapiens
[Reaction:R-HSA-9707186] ALOX5 binds ALOX5 inhibitors - Homo sapiens
[Reaction:R-HSA-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Homo sapiens
[Reaction:R-HSA-266072] LTA4 is hydolysed to LTB4 by LTA4H - Homo sapiens
[Reaction:R-HSA-2161567] LTB4 is oxidised to 12-oxoLTB4 by PTGR1 - Homo sapiens
[Reaction:R-HSA-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Homo sapiens
[Reaction:R-HSA-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 - Homo sapiens
[Reaction:R-HSA-2161792] 20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3 - Homo sapiens
[Reaction:R-HSA-2161979] 20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH - Homo sapiens
[BlackBoxEvent:R-HSA-2161790] 20cooh-LTB4 is converted to 18cooh-LTB4 - Homo sapiens
[Reaction:R-HSA-266050] LTA4 is converted to LTC4 by LTC4S - Homo sapiens
[Reaction:R-HSA-266070] LTC4 is exported from the cytosol by ABCC1 - Homo sapiens
[Reaction:R-HSA-266046] GGT1, 5 dimers hydrolyse LTC4 to LTD4 - Homo sapiens
[Reaction:R-HSA-266012] LTD4 is converted to LTE4 by DPEP1/2 - Homo sapiens
[Reaction:R-HSA-2161962] LTA4 is hydrolysed to 6t-/6t,12epi-LTB4 - Homo sapiens
[Reaction:R-HSA-2162019] LTA4 is converted to EXA4 by ALOX15 - Homo sapiens
[Reaction:R-HSA-2161768] EXA4 is converted to EXC4 by LTC4S - Homo sapiens
[Reaction:R-HSA-2161945] EXC4 is converted to EXD4 by GGT - Homo sapiens
[Reaction:R-HSA-2161868] EXD4 is converted to EXE4 by DPEP - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年06月09日
literatureReference
[LiteratureReference:2162106] On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma
[LiteratureReference:2162148] Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
[Book:2142759] Vance, Dennis E 978-0-444-53219-0 Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways
[LiteratureReference:266078] Biosynthesis and metabolism of leukotrienes
[LiteratureReference:266079] Leukotrienes
maxDepth
2
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Synthesis of Leukotrienes (LT) and Eoxins (EX)
orthologousEvent
[Pathway:R-MMU-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Mus musculus
[Pathway:R-RNO-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Rattus norvegicus
[Pathway:R-CFA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Canis familiaris
[Pathway:R-BTA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Bos taurus
[Pathway:R-SSC-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Sus scrofa
[Pathway:R-DRE-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Danio rerio
[Pathway:R-XTR-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Xenopus tropicalis
[Pathway:R-GGA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Gallus gallus
[Pathway:R-DME-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Drosophila melanogaster
[Pathway:R-CEL-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Caenorhabditis elegans
[Pathway:R-DDI-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Dictyostelium discoideum
[Pathway:R-SPO-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Schizosaccharomyces pombe
[Pathway:R-SCE-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Saccharomyces cerevisiae
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2012年12月04日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2569042] Rush, MG, 2012年11月10日
[InstanceEdit:9917333] Hill, David P, 2024年08月02日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-2142691
summation
[Summation:2162113] Leukotrienes (LTs) are biologically active molecules formed ...
updateTrackers
[UpdateTracker:9786310] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v50:[updateContainedRLE]
[UpdateTracker:9779031] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v66:[updateContainedRLE]
[UpdateTracker:9919368] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v90:[modifyText]
[UpdateTracker:9781682] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v60:[updateContainedRLE]
[UpdateTracker:9774788] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v81:[addHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-2142753] Arachidonate metabolism
(replacementInstances)
[Deleted:5567296] Deletion of instance: 265309
(updatedInstance)
[UpdateTracker:9786310] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v50:[updateContainedRLE]
[UpdateTracker:9779031] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v66:[updateContainedRLE]
[UpdateTracker:9919368] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v90:[modifyText]
[UpdateTracker:9781682] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v60:[updateContainedRLE]
[UpdateTracker:9774788] Update Tracker - [Pathway:2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - v81:[addHasEvent]
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