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Entries
LTD4 is converted to LTE4 by DPEP1/2
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authored
[InstanceEdit:378946] Jassal, Bijay, 2008年10月01日
catalystActivity
[CatalystActivity:266039] dipeptidase activity of DPEP1,2 dimers [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:266031] Jassal, B, 2008年04月21日 14:30:43
crossReference
[DatabaseIdentifier:12611210] Rhea:48617
[DatabaseIdentifier:9915903] RHEA:48617
dbId
266012
displayName
LTD4 is converted to LTE4 by DPEP1/2
edited
[InstanceEdit:266011] Jassal, B, 2008年04月21日 14:30:22
eventOf
[Pathway:R-HSA-9664535] LTC4-CYSLTR mediated IL4 production - Homo sapiens
[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Homo sapiens
input
[SimpleEntity:R-ALL-109276] H2O [extracellular region]
[SimpleEntity:R-ALL-266074] LTD4 [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:266028] Release and functional characterization of the leukotriene D4-metabolizing enzyme (dipeptidase) from human polymorphonuclear leucocytes
[LiteratureReference:266042] Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes
[LiteratureReference:2162134] Purification and characterization of human microsomal dipeptidase
maxDepth
1
modified
[InstanceEdit:11001822] Weiser, Joel, 2025年08月28日
name
LTD4 is converted to LTE4 by DPEP1/2
H2O + leukotriene D4 => glycine + leukotriene E4
Further cleavage of LTD4 forms LTE4
orthologousEvent
[Reaction:R-SPO-266012] LTD4 is converted to LTE4 by DPEP1/2 - Schizosaccharomyces pombe
[Reaction:R-DME-266012] LTD4 is converted to LTE4 by DPEP1/2 - Drosophila melanogaster
[Reaction:R-GGA-266012] LTD4 is converted to LTE4 by DPEP1/2 - Gallus gallus
[Reaction:R-SSC-266012] LTD4 is converted to LTE4 by DPEP1/2 - Sus scrofa
[Reaction:R-BTA-266012] LTD4 is converted to LTE4 by DPEP1/2 - Bos taurus
[Reaction:R-CFA-266012] LTD4 is converted to LTE4 by DPEP1/2 - Canis familiaris
[Reaction:R-RNO-266012] LTD4 is converted to LTE4 by DPEP1/2 - Rattus norvegicus
[Reaction:R-MMU-266012] LTD4 is converted to LTE4 by DPEP1/2 - Mus musculus
output
[SimpleEntity:R-ALL-266029] Gly [extracellular region]
[SimpleEntity:R-ALL-266033] LTE4 [extracellular region]
releaseDate
2008年12月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2569042] Rush, MG, 2012年11月10日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-266012
summation
[Summation:266054] Another outer surface membrane-bound, homodimeric enzyme, di...
updateTrackers
[UpdateTracker:9788629] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v41:[addLiteratureReference, modifyText]
[UpdateTracker:9790621] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v33:[addInput]
[UpdateTracker:9788294] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v43:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788629] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v41:[addLiteratureReference, modifyText]
[UpdateTracker:9790621] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v33:[addInput]
[UpdateTracker:9788294] Update Tracker - [Reaction:266012] LTD4 is converted to LTE4 by DPEP1/2 - v43:[modifyText]
(hasEvent)
[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
[Pathway:R-HSA-9664535] LTC4-CYSLTR mediated IL4 production
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