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20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH Show undefined attributes

authored

[InstanceEdit:2142839] Williams, MG, 2012年02月24日

catalystActivity

[CatalystActivity:2161683] 20-aldehyde-leukotriene B4 20-monooxygenase activity of ALDH [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:2161780] Williams, MG, 2012年03月14日

crossReference

[DatabaseIdentifier:9915867] RHEA:48673

dbId 2161979

displayName 20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH

edited

[InstanceEdit:2142839] Williams, MG, 2012年02月24日

eventOf

[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-2161790] 20cooh-LTB4 is converted to 18cooh-LTB4 - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:2161943] Identification of an aldehyde dehydrogenase in the microsomes of human polymorphonuclear leukocytes that metabolizes 20-aldehyde leukotriene B4

maxDepth 1

modified [InstanceEdit:9915866] D'Eustachio, Peter, 2024年07月17日

name

20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH
20-oxo-leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-carboxy-leukotriene B4 + 2 H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

output

precedingEvent

[Reaction:R-HSA-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 - Homo sapiens

releaseDate 2012年03月13日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2569042] Rush, MG, 2012年11月10日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2161979

summation

[Summation:2162013] An aldehyde dehydrogenase (ALDH) yet to be cloned in humans ...

Referrals

(precedingEvent)

[BlackBoxEvent:R-HSA-2161790] 20cooh-LTB4 is converted to 18cooh-LTB4

(hasEvent)

[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)

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