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Entries
CYP4F2, 4F3 20-hydroxylate LTB4
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authored
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
catalystActivity
[CatalystActivity:2162138] leukotriene-B4 20-monooxygenase activity of Cytochrome P450 (CYP4F2/4F3 based) [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:211969] Jassal, B, 2008年02月08日 15:33:52
crossReference
[DatabaseIdentifier:9915860] RHEA:22177
dbId
211873
displayName
CYP4F2, 4F3 20-hydroxylate LTB4
edited
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
eventOf
[Pathway:R-HSA-211979] Eicosanoids - Homo sapiens
[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Homo sapiens
followingEvent
[Reaction:R-HSA-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3 - Homo sapiens
input
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-266056] LTB4 [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:215515] Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4
[LiteratureReference:215553] Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization
maxDepth
1
modified
[InstanceEdit:10603480] Weiser, Joel, 2025年08月27日
name
CYP4F2, 4F3 20-hydroxylate LTB4
leukotriene B4 + O2 + reduced (NADPH--hemoprotein reductase) => 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
CYP4F2 omega-hydroxylates leukotriene B4, thus inactivating it
orthologousEvent
[Reaction:R-XTR-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Xenopus tropicalis
[Reaction:R-DRE-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Danio rerio
[Reaction:R-SSC-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Sus scrofa
[Reaction:R-BTA-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Bos taurus
[Reaction:R-CFA-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Canis familiaris
[Reaction:R-RNO-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Rattus norvegicus
[Reaction:R-MMU-211873] CYP4F2, 4F3 20-hydroxylate LTB4 - Mus musculus
output
[SimpleEntity:R-ALL-2161636] 20OH-LTB4 [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent
[Reaction:R-HSA-266072] LTA4 is hydolysed to LTB4 by LTA4H - Homo sapiens
releaseDate
2008年06月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2569042] Rush, MG, 2012年11月10日
revised
[InstanceEdit:5602271] Jassal, Bijay, 2014年06月23日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-211873
summation
[Summation:215523] Leukotriene B4 (LTB4) is formed from arachidonate and is a p...
updateTrackers
[UpdateTracker:9786335] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v50:[modifyText]
[UpdateTracker:9919468] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v90:[modifyText]
[UpdateTracker:9790415] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v33:[addOutput]
[UpdateTracker:9788705] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v41:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9786335] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v50:[modifyText]
[UpdateTracker:9919468] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v90:[modifyText]
[UpdateTracker:9790415] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v33:[addOutput]
[UpdateTracker:9788705] Update Tracker - [Reaction:211873] CYP4F2, 4F3 20-hydroxylate LTB4 - v41:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
(hasEvent)
[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
[Pathway:R-HSA-211979] Eicosanoids
(precedingEvent)
[Reaction:R-HSA-2161745] 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
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