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Entries
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
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authored
[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006年02月02日
category
binding
compartment
[Compartment:947587] cytoplasmic side of plasma membrane
created
[InstanceEdit:173513] Jassal, B, 2006年02月10日 14:02:35
dbId
173512
displayName
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
edited
[InstanceEdit:173513] Jassal, B, 2006年02月10日 14:02:35
[InstanceEdit:2187413] Jassal, B, 2012年04月10日
eventOf
[Pathway:R-HSA-2173788] Downregulation of TGF-beta receptor signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-178189] SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:23765] negative regulation of transforming growth factor beta receptor signaling pathway
input
[EntityWithAccessionedSequence:R-HSA-173478] SMAD7 [cytosol]
[Complex:R-HSA-170841] TGFB1:TGFBR2:p-TGFBR1 [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:178160] Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
[LiteratureReference:178152] The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
orthologousEvent
[Reaction:R-CEL-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Caenorhabditis elegans
[Reaction:R-DME-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Drosophila melanogaster
[Reaction:R-GGA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Gallus gallus
[Reaction:R-DRE-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Danio rerio
[Reaction:R-SSC-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Sus scrofa
[Reaction:R-BTA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Bos taurus
[Reaction:R-CFA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Canis familiaris
[Reaction:R-RNO-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Rattus norvegicus
[Reaction:R-MMU-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Mus musculus
output
[Complex:R-HSA-173476] TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]
precedingEvent
[BlackBoxEvent:R-HSA-2106591] WWTR1:SMAD stimulates transcription of SMAD7 - Homo sapiens
releaseDate
2006年04月24日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:178196] Heldin, CH, 2006年04月18日 14:26:12
[InstanceEdit:2250308] Huang, Tao, 2012年05月14日
revised
[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-173512
summation
[Summation:173491] I-SMADs (SMAD6 and SMAD7) reside in the nucleus presumably t...
updateTrackers
[UpdateTracker:9788586] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v41:[add_removeInput]
[UpdateTracker:9792518] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v20:[removeCatalystActivity]
[UpdateTracker:9789418] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v38:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788586] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v41:[add_removeInput]
[UpdateTracker:9792518] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v20:[removeCatalystActivity]
[UpdateTracker:9789418] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v38:[modifyText]
(hasEvent)
[Pathway:R-HSA-2173788] Downregulation of TGF-beta receptor signaling
(precedingEvent)
[Reaction:R-HSA-178189] SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR
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