Reactome Pathway Database

Schema > Reaction > Entries

I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) Show undefined attributes

category binding

compartment

[Compartment:947587] cytoplasmic side of plasma membrane

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 9978589

displayName I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)

eventOf

[Pathway:R-MMU-2173788] Downregulation of TGF-beta receptor signaling - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:23765] negative regulation of transforming growth factor beta receptor signaling pathway

inferredFrom

[Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)

output

[Complex:R-MMU-173476] TGFB1: p-TGFBR: I-SMAD7 [plasma membrane]

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-173512

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-2173788] Downregulation of TGF-beta receptor signaling

(inferredTo)

[Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)

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