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Schema
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BlackBoxEvent
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Entries
WWTR1:SMAD stimulates transcription of SMAD7
Show undefined attributes
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authored
[InstanceEdit:2186634] Orlic-Milacic, M, 2012年04月04日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:2106589] Orlic-Milacic, M, 2012年02月10日
dbId
2106591
displayName
WWTR1:SMAD stimulates transcription of SMAD7
edited
[InstanceEdit:2187413] Jassal, B, 2012年04月10日
[InstanceEdit:9773750] Orlic-Milacic, Marija, 2022年05月09日
eventOf
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
followingEvent
[Reaction:R-HSA-178208] SMAD7 binds to SMURF2 - Homo sapiens
[Reaction:R-HSA-2167917] SMAD7 binds to SMURF1 - Homo sapiens
[Reaction:R-HSA-2176416] NEDD4L ubiquitin ligase binds SMAD7 - Homo sapiens
[Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - Homo sapiens
[Reaction:R-HSA-2186771] RNF111 binds SMAD7 - Homo sapiens
[Reaction:R-HSA-9736966] SMAD7 binds SERPINE1 gene promoter - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-2106587] SMAD7 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2031354] TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
[LiteratureReference:5251997] Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
WWTR1:SMAD stimulates transcription of SMAD7
output
[EntityWithAccessionedSequence:R-HSA-178197] SMAD7 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-9736970] WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter - Homo sapiens
[Reaction:R-HSA-5252001] ATP1B4 binds SNW1 - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:R-HSA-2106584] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-5255397] Positive gene expression regulation by 'ATP1B4:SNW1 [nucleoplasm]'
regulationReference
[RegulationReference:9642308] Positive gene expression regulation by 'WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene [nucleoplasm]' TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2250308] Huang, Tao, 2012年05月14日
[InstanceEdit:9773670] Contreras, Osvaldo, 2022年05月02日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-2106591
summation
[Summation:2106596] Knocking down WWTR1 (TAZ) expression by siRNA treatment inhi...
updateTrackers
[UpdateTracker:9775746] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v78:[add_removeRegulator]
[UpdateTracker:9785313] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v52:[addLiteratureReference, addRegulator, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775746] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v78:[add_removeRegulator]
[UpdateTracker:9785313] Update Tracker - [BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 - v52:[addLiteratureReference, addRegulator, modifyText]
(precedingEvent)
[Reaction:R-HSA-178208] SMAD7 binds to SMURF2
[Reaction:R-HSA-2167917] SMAD7 binds to SMURF1
[Reaction:R-HSA-2176416] NEDD4L ubiquitin ligase binds SMAD7
[Reaction:R-HSA-173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
[Reaction:R-HSA-9736966] SMAD7 binds SERPINE1 gene promoter
[Reaction:R-HSA-2186771] RNF111 binds SMAD7
(hasEvent)
[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
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