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Schema
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Pathway
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Entries
Frs2-mediated activation
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authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006年10月10日
created
[InstanceEdit:170970] Jassal, B, 2006年01月25日 09:53:37
crossReference
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757882] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
170968
displayName
Frs2-mediated activation
edited
[InstanceEdit:188340] Jassal, Bijay, 2006年10月10日
eventOf
[Pathway:R-HSA-169893] Prolonged ERK activation events - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-170964] FRS2 binds to active TrkA receptor - Homo sapiens
[Reaction:R-HSA-170977] FRS2 is phosphorylated by active TrkA receptor - Homo sapiens
[Reaction:R-HSA-170975] p-FRS2 binds CRKL - Homo sapiens
[Reaction:R-HSA-170978] p-FRS2:CRKL binds C3G - Homo sapiens
[Reaction:R-HSA-170979] (Frs2)C3G stimulates nucleotide exchange on Rap1 - Homo sapiens
[Reaction:R-HSA-170965] (Frs2)Rap1-GTP binds to and activates B-Raf - Homo sapiens
[Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Homo sapiens
[Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Homo sapiens
[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens
[Reaction:R-HSA-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Homo sapiens
[BlackBoxEvent:R-HSA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Homo sapiens
[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
[BlackBoxEvent:R-HSA-9610166] p-T,Y MAPK dimers translocate to nucleus - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年09月09日
literatureReference
[LiteratureReference:190211] Signal transduction by the neurotrophin receptors
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Frs2-mediated activation
orthologousEvent
[Pathway:R-MMU-170968] Frs2-mediated activation - Mus musculus
[Pathway:R-RNO-170968] Frs2-mediated activation - Rattus norvegicus
[Pathway:R-BTA-170968] Frs2-mediated activation - Bos taurus
[Pathway:R-SSC-170968] Frs2-mediated activation - Sus scrofa
[Pathway:R-DRE-170968] Frs2-mediated activation - Danio rerio
[Pathway:R-XTR-170968] Frs2-mediated activation - Xenopus tropicalis
[Pathway:R-GGA-170968] Frs2-mediated activation - Gallus gallus
[Pathway:R-DME-170968] Frs2-mediated activation - Drosophila melanogaster
[Pathway:R-CEL-170968] Frs2-mediated activation - Caenorhabditis elegans
[Pathway:R-DDI-170968] Frs2-mediated activation - Dictyostelium discoideum
[Pathway:R-SPO-170968] Frs2-mediated activation - Schizosaccharomyces pombe
[Pathway:R-SCE-170968] Frs2-mediated activation - Saccharomyces cerevisiae
[Pathway:R-PFA-170968] Frs2-mediated activation - Plasmodium falciparum
[Pathway:R-CFA-170968] Frs2-mediated activation - Canis familiaris
releaseDate
2007年12月11日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:202668] Greene, LA, 2007年11月08日 15:39:37
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-170968
summation
[Summation:190214] The adaptor protein Frs2 (Fibroblast growth factor receptor ...
updateTrackers
[UpdateTracker:9787980] Update Tracker - [Pathway:170968] Frs2-mediated activation - v44:[updateContainedRLE]
[UpdateTracker:9784793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v53:[add_removeHasEvent]
[UpdateTracker:9779257] Update Tracker - [Pathway:170968] Frs2-mediated activation - v66:[updateContainedRLE]
[UpdateTracker:9783497] Update Tracker - [Pathway:170968] Frs2-mediated activation - v56:[updateContainedPathway]
[UpdateTracker:9780437] Update Tracker - [Pathway:170968] Frs2-mediated activation - v63:[updateContainedRLE]
[UpdateTracker:9780818] Update Tracker - [Pathway:170968] Frs2-mediated activation - v62:[removeHasEvent]
[UpdateTracker:9778793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v67:[addHasEvent]
[UpdateTracker:9791828] Update Tracker - [Pathway:170968] Frs2-mediated activation - v25:[updateContainedRLE]
[UpdateTracker:9777598] Update Tracker - [Pathway:170968] Frs2-mediated activation - v70:[addHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-169893] Prolonged ERK activation events
(updatedInstance)
[UpdateTracker:9787980] Update Tracker - [Pathway:170968] Frs2-mediated activation - v44:[updateContainedRLE]
[UpdateTracker:9784793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v53:[add_removeHasEvent]
[UpdateTracker:9779257] Update Tracker - [Pathway:170968] Frs2-mediated activation - v66:[updateContainedRLE]
[UpdateTracker:9783497] Update Tracker - [Pathway:170968] Frs2-mediated activation - v56:[updateContainedPathway]
[UpdateTracker:9780437] Update Tracker - [Pathway:170968] Frs2-mediated activation - v63:[updateContainedRLE]
[UpdateTracker:9780818] Update Tracker - [Pathway:170968] Frs2-mediated activation - v62:[removeHasEvent]
[UpdateTracker:9778793] Update Tracker - [Pathway:170968] Frs2-mediated activation - v67:[addHasEvent]
[UpdateTracker:9791828] Update Tracker - [Pathway:170968] Frs2-mediated activation - v25:[updateContainedRLE]
[UpdateTracker:9777598] Update Tracker - [Pathway:170968] Frs2-mediated activation - v70:[addHasEvent]
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