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Schema
>
Reaction
>
Entries
BRAF autophosphorylates downstream of RAP1 and NGF
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authored
[InstanceEdit:9610162] Rothfels, Karen, 2018年06月05日
catalystActivity
[CatalystActivity:9610159] protein serine/threonine kinase activity of RAP1:GTP:B-Raf complex [endosome membrane]
category
transition
compartment
[Compartment:74700] endosome membrane
created
[InstanceEdit:9610162] Rothfels, Karen, 2018年06月05日
dbId
9610163
displayName
BRAF autophosphorylates downstream of RAP1 and NGF
eventOf
[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent
[Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Homo sapiens
[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-190082] RAP1:GTP:B-Raf complex [endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:182076] Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells
[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
BRAF autophosphorylates downstream of RAP1 and NGF
orthologousEvent
[Reaction:R-CEL-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Caenorhabditis elegans
[Reaction:R-DME-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Drosophila melanogaster
[Reaction:R-GGA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Gallus gallus
[Reaction:R-SSC-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Sus scrofa
[Reaction:R-BTA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Bos taurus
[Reaction:R-RNO-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Rattus norvegicus
[Reaction:R-MMU-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-9610130] RAP1:GTP:activated BRAF dimer [endosome membrane]
precedingEvent
[Reaction:R-HSA-170965] (Frs2)Rap1-GTP binds to and activates B-Raf - Homo sapiens
releaseDate
2019年09月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9658256] D'Eustachio, Peter, 2019年08月12日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9610163
summation
[Summation:9610165] After recruitment by RAP1 to the endosome, BRAF is activated...
Referrals
(hasEvent)
[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)
[Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome
[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
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