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PC is exchanged with PI by PITPNB
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authored
[InstanceEdit:1678579] Williams, MG, 2011年10月18日
catalystActivity
[CatalystActivity:9855941] phosphatidylcholine transfer activity of PC:PITPNB [endoplasmic reticulum membrane]
catalystActivityReference
[CatalystActivityReference:9855945] phosphatidylcholine transfer activity of PC:PITPNB [endoplasmic reticulum membrane] Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:1483214] Williams, MG, 2011年08月12日
dbId
1483219
displayName
PC is exchanged with PI by PITPNB
edited
[InstanceEdit:1482514] Williams, MG, 2011年08月12日
eventOf
[Pathway:R-HSA-1483196] PI and PC transport between ER and Golgi membranes - Homo sapiens
followingEvent
[Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6 - Homo sapiens
[Reaction:R-HSA-1483229] PI:PITPNB is transported from the ER membrane to the Golgi membrane - Homo sapiens
[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens
[Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Homo sapiens
[Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens
[Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Homo sapiens
[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens
[Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1 - Homo sapiens
input
[Complex:R-HSA-1524110] PC:PITPNB [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1483105] Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells
[LiteratureReference:1483109] Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum
[LiteratureReference:1483200] Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine
[LiteratureReference:1483223] Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms
[LiteratureReference:1483130] Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association
[LiteratureReference:1483188] Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
PC is exchanged with PI by PITPNB
orthologousEvent
[Reaction:R-MMU-1483219] PC is exchanged with PI by PITPNB - Mus musculus
[Reaction:R-RNO-1483219] PC is exchanged with PI by PITPNB - Rattus norvegicus
[Reaction:R-CFA-1483219] PC is exchanged with PI by PITPNB - Canis familiaris
[Reaction:R-BTA-1483219] PC is exchanged with PI by PITPNB - Bos taurus
[Reaction:R-SSC-1483219] PC is exchanged with PI by PITPNB - Sus scrofa
[Reaction:R-XTR-1483219] PC is exchanged with PI by PITPNB - Xenopus tropicalis
[Reaction:R-PFA-1483219] PC is exchanged with PI by PITPNB - Plasmodium falciparum
[Reaction:R-DDI-1483219] PC is exchanged with PI by PITPNB - Dictyostelium discoideum
[Reaction:R-CEL-1483219] PC is exchanged with PI by PITPNB - Caenorhabditis elegans
[Reaction:R-DME-1483219] PC is exchanged with PI by PITPNB - Drosophila melanogaster
[Reaction:R-GGA-1483219] PC is exchanged with PI by PITPNB - Gallus gallus
output
[SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
[Complex:R-HSA-1524117] PI:PITPNB [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1483211] PC:PITPNB is transported from the Golgi membrane to the ER membrane - Homo sapiens
[Reaction:R-HSA-1482976] CDP-DAG is converted to PI by CDIPT - Homo sapiens
[Reaction:R-HSA-1482598] 1-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens
[Reaction:R-HSA-1482626] 2-acyl LPI is acylated to PI by MBOAT7 - Homo sapiens
[Reaction:R-HSA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2247963] Wakelam, Michael, 2012年05月14日
[InstanceEdit:9860910] Hill, David P, 2024年02月12日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1483219
summation
[Summation:1482923] At the ER membrane, phosphatidylcholine (PC) is exchanged fo...
updateTrackers
[UpdateTracker:9863958] Update Tracker - [Reaction:1483219] PC is exchanged with PI by PITPNB - v88:[addCatalystActivity, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9863958] Update Tracker - [Reaction:1483219] PC is exchanged with PI by PITPNB - v88:[addCatalystActivity, modifyText]
(precedingEvent)
[Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6
[Reaction:R-HSA-1483229] PI:PITPNB is transported from the ER membrane to the Golgi membrane
[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2
[Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5]
[Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C
[Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1
[Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6]
[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7]
(hasEvent)
[Pathway:R-HSA-1483196] PI and PC transport between ER and Golgi membranes
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