Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
PI4P is dephosphorylated to PI by SACM1L at the ER membrane
Show undefined attributes
Go to Details
authored
[InstanceEdit:1678579] Williams, MG, 2011年10月18日
catalystActivity
[CatalystActivity:1806179] phosphatidylinositol phosphate 4-phosphatase activity of SACM1L [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1676083] Williams, MG, 2011年10月17日
crossReference
[DatabaseIdentifier:12610433] Rhea:55652
dbId
1676124
displayName
PI4P is dephosphorylated to PI by SACM1L at the ER membrane
edited
[InstanceEdit:1482514] Williams, MG, 2011年08月12日
eventOf
[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane - Homo sapiens
followingEvent
[Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Homo sapiens
[Reaction:R-HSA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12] - Homo sapiens
[Reaction:R-HSA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13] - Homo sapiens
[Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11] - Homo sapiens
[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-1806234] PI4P [endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1675768] The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
PI4P is dephosphorylated to PI by SACM1L at the ER membrane
orthologousEvent
[Reaction:R-MMU-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Mus musculus
[Reaction:R-CFA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Canis familiaris
[Reaction:R-BTA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Bos taurus
[Reaction:R-SCE-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Saccharomyces cerevisiae
[Reaction:R-SPO-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Schizosaccharomyces pombe
[Reaction:R-DRE-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Danio rerio
[Reaction:R-SSC-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Sus scrofa
[Reaction:R-PFA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Plasmodium falciparum
[Reaction:R-DDI-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Dictyostelium discoideum
[Reaction:R-CEL-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Caenorhabditis elegans
[Reaction:R-DME-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Drosophila melanogaster
[Reaction:R-GGA-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Gallus gallus
[Reaction:R-RNO-1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - Rattus norvegicus
output
[SimpleEntity:R-ALL-29372] Pi [cytosol]
[SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane - Homo sapiens
[Reaction:R-HSA-8867667] OSBPs transport 25OH-CHOL from ER membrane to plasma membrane - Homo sapiens
[Reaction:R-HSA-8868402] OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane - Homo sapiens
[Reaction:R-HSA-8867876] OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2247963] Wakelam, Michael, 2012年05月14日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1676124
summation
[Summation:1676026] At the endoplasmic reticulum (ER) membrane, transmembrane pr...
updateTrackers
[UpdateTracker:9783624] Update Tracker - [Reaction:1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - v56:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9783624] Update Tracker - [Reaction:1676124] PI4P is dephosphorylated to PI by SACM1L at the ER membrane - v56:[modifyText]
(hasEvent)
[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane
(precedingEvent)
[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB
[Reaction:R-HSA-1482868] PI is hydrolyzed to 1-acyl LPI by PLA2[12]
[Reaction:R-HSA-1482932] PI is hydrolyzed to 2-acyl LPI by PLA2[13]
[Reaction:R-HSA-1482825] PI is hydrolyzed to 1-acyl LPI by PLA2[11]
[Reaction:R-HSA-1675813] PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル