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Entries
PC is hydrolyzed to 1-acyl LPC by PLA2[5]
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authored
[InstanceEdit:1602345] Williams, MG, 2011年09月14日
catalystActivity
[CatalystActivity:1524124] phospholipase A2 activity of PLA2(5) [cytosol]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1482800] Williams, MG, 2011年08月12日
dbId
1482856
displayName
PC is hydrolyzed to 1-acyl LPC by PLA2[5]
edited
[InstanceEdit:1482514] Williams, MG, 2011年08月12日
eventOf
[Pathway:R-HSA-1482788] Acyl chain remodelling of PC - Homo sapiens
followingEvent
[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens
[Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C - Homo sapiens
[Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1482693] The identification of a phospholipase B precursor in human neutrophils
[LiteratureReference:1482664] Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms
[LiteratureReference:378474] A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP
[LiteratureReference:1482518] Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2
[LiteratureReference:1482841] Molecular characterization of cytosolic phospholipase A2-beta
[LiteratureReference:1482573] A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2
[LiteratureReference:1482885] Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2
[LiteratureReference:1482631] Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)
[LiteratureReference:1482624] Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)
[LiteratureReference:1482909] Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin
[LiteratureReference:1482893] Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity
[LiteratureReference:1482851] Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1
[LiteratureReference:1482872] The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene
[LiteratureReference:1482854] Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
PC is hydrolyzed to 1-acyl LPC by PLA2[5]
orthologousEvent
[Reaction:R-SSC-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Sus scrofa
[Reaction:R-XTR-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Xenopus tropicalis
[Reaction:R-GGA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Gallus gallus
[Reaction:R-SCE-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Saccharomyces cerevisiae
[Reaction:R-SPO-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Schizosaccharomyces pombe
[Reaction:R-DDI-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Dictyostelium discoideum
[Reaction:R-CEL-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Caenorhabditis elegans
[Reaction:R-DME-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Drosophila melanogaster
[Reaction:R-DRE-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Danio rerio
[Reaction:R-BTA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Bos taurus
[Reaction:R-CFA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Canis familiaris
[Reaction:R-RNO-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Rattus norvegicus
[Reaction:R-MMU-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Mus musculus
output
[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Homo sapiens
[Reaction:R-HSA-1483219] PC is exchanged with PI by PITPNB - Homo sapiens
[Reaction:R-HSA-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Homo sapiens
[Reaction:R-HSA-1482533] 2-acyl LPC is acylated to PC by LPCAT - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1482856
summation
[Summation:1482876] At the endoplasmic reticulum (ER) membrane, phosphatidylchol...
Referrals
(hasEvent)
[Pathway:R-HSA-1482788] Acyl chain remodelling of PC
(precedingEvent)
[Reaction:R-HSA-1482547] 1-acyl LPC is acylated to PC by LPCAT
[Reaction:R-HSA-1482696] 1-acyl LPC is hydrolyzed to GPCho by PLA2G4C
[Reaction:R-HSA-1482685] 1-acyl LPC is hydrolyzed to GPCho by PLA2[8]
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