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1-acyl LPC is acylated to PC by LPCAT
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authored
[InstanceEdit:1602345] Williams, MG, 2011年09月14日
catalystActivity
[CatalystActivity:1524024] 1-acylglycerol-3-phosphate O-acyltransferase activity of LPCAT [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:1482525] Williams, MG, 2011年08月12日
crossReference
[DatabaseIdentifier:12610440] Rhea:12937
dbId
1482547
displayName
1-acyl LPC is acylated to PC by LPCAT
edited
[InstanceEdit:1482514] Williams, MG, 2011年08月12日
eventOf
[Pathway:R-HSA-1482788] Acyl chain remodelling of PC - Homo sapiens
followingEvent
[Reaction:R-HSA-8873923] STARD10 binds LPCAT1 and PC - Homo sapiens
[Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Homo sapiens
[Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Homo sapiens
[Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6 - Homo sapiens
[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Homo sapiens
[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens
[Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens
[Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1 - Homo sapiens
input
[SimpleEntity:R-ALL-1524028] 1-acyl LPC [endoplasmic reticulum membrane]
[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1482687] Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2
[LiteratureReference:1482553] Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7
[LiteratureReference:429001] Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils
[LiteratureReference:1482541] Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production
[LiteratureReference:1482640] Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells
[LiteratureReference:1482581] A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase
[LiteratureReference:429002] Identification and characterization of a major liver lysophosphatidylcholine acyltransferase
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
1-acyl LPC is acylated to PC by LPCAT
orthologousEvent
[Reaction:R-PFA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Plasmodium falciparum
[Reaction:R-MMU-1482547] 1-acyl LPC is acylated to PC by LPCAT - Mus musculus
[Reaction:R-SSC-1482547] 1-acyl LPC is acylated to PC by LPCAT - Sus scrofa
[Reaction:R-XTR-1482547] 1-acyl LPC is acylated to PC by LPCAT - Xenopus tropicalis
[Reaction:R-GGA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Gallus gallus
[Reaction:R-SCE-1482547] 1-acyl LPC is acylated to PC by LPCAT - Saccharomyces cerevisiae
[Reaction:R-SPO-1482547] 1-acyl LPC is acylated to PC by LPCAT - Schizosaccharomyces pombe
[Reaction:R-DDI-1482547] 1-acyl LPC is acylated to PC by LPCAT - Dictyostelium discoideum
[Reaction:R-CEL-1482547] 1-acyl LPC is acylated to PC by LPCAT - Caenorhabditis elegans
[Reaction:R-DME-1482547] 1-acyl LPC is acylated to PC by LPCAT - Drosophila melanogaster
[Reaction:R-DRE-1482547] 1-acyl LPC is acylated to PC by LPCAT - Danio rerio
[Reaction:R-BTA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Bos taurus
[Reaction:R-CFA-1482547] 1-acyl LPC is acylated to PC by LPCAT - Canis familiaris
[Reaction:R-RNO-1482547] 1-acyl LPC is acylated to PC by LPCAT - Rattus norvegicus
output
[SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
[SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5] - Homo sapiens
[Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6] - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1482547
summation
[Summation:1482610] At the endoplasmic reticulum (ER) membrane, lysophospholipid...
Referrals
(precedingEvent)
[Reaction:R-HSA-1483142] PC is transphosphatidylated to PG by PLD1-4/6
[Reaction:R-HSA-8873923] STARD10 binds LPCAT1 and PC
[Reaction:R-HSA-1483182] PC is hydrolyzed to PA and choline by PLD1/2
[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7]
[Reaction:R-HSA-1482856] PC is hydrolyzed to 1-acyl LPC by PLA2[5]
[Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C
[Reaction:R-HSA-1483186] PC is converted to PS by PTDSS1
[Reaction:R-HSA-1482816] PC is hydrolyzed to 1-acyl LPC by PLA2[6]
(hasEvent)
[Pathway:R-HSA-1482788] Acyl chain remodelling of PC
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