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Schema
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Pathway
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Entries
Apoptotic cleavage of cellular proteins
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authored
[InstanceEdit:201620] Schulze-Osthoff, K, 2007年09月03日 07:52:18
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:111451] Alnemri, E, 2004年02月17日 00:23:30
crossReference
[DatabaseIdentifier:12758080] BioModels Database:BIOMD0000000243
[DatabaseIdentifier:12757940] BioModels Database:BIOMD0000000220
[DatabaseIdentifier:12757942] BioModels Database:BIOMD0000000407
dbId
111465
displayName
Apoptotic cleavage of cellular proteins
edited
[InstanceEdit:211689] Matthews, L, 2008年02月08日 00:41:49
eventOf
[Pathway:R-HSA-75153] Apoptotic execution phase - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Pathway:R-HSA-264870] Caspase-mediated cleavage of cytoskeletal proteins - Homo sapiens
[Pathway:R-HSA-351906] Apoptotic cleavage of cell adhesion proteins - Homo sapiens
[Pathway:R-HSA-352238] Breakdown of the nuclear lamina - Homo sapiens
[Reaction:R-HSA-202947] Caspase mediated cleavage of APC - Homo sapiens
[Reaction:R-HSA-202960] Caspase mediated cleavage of C-IAP1 - Homo sapiens
[Reaction:R-HSA-201634] Caspase-mediated cleavage of FADK 1 - Homo sapiens
[Reaction:R-HSA-212552] Caspase 3-mediated cleavage of PKC delta - Homo sapiens
[Reaction:R-HSA-201603] Caspase-mediated cleavage of PKC theta - Homo sapiens
[Reaction:R-HSA-201630] Caspase-mediated cleavage of Acinus - Homo sapiens
[Reaction:R-HSA-201611] Caspase-mediated cleavage of Rock-1 - Homo sapiens
[Reaction:R-HSA-201640] Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha - Homo sapiens
[Reaction:R-HSA-351894] Caspase mediated cleavage of BAP31 - Homo sapiens
[Reaction:R-HSA-351849] Caspase-mediated cleavage of Etk - Homo sapiens
[Reaction:R-HSA-350651] Caspase-mediated cleavage of MASK - Homo sapiens
[Reaction:R-HSA-351901] Caspase-mediated cleavage of MST3 - Homo sapiens
[BlackBoxEvent:R-HSA-9029680] Caspase-7 translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-351936] Caspase-mediated cleavage of claspin - Homo sapiens
[Reaction:R-HSA-352268] Cleavage of Satb1 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018年03月26日
literatureReference
[LiteratureReference:201563] Many cuts to ruin: a comprehensive update of caspase substrates
[LiteratureReference:204058] SVM-based prediction of caspase substrate cleavage sites
[LiteratureReference:204068] CASVM: web server for SVM-based prediction of caspase substrates cleavage sites
maxDepth
3
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Apoptotic cleavage of cellular proteins
orthologousEvent
[Pathway:R-MMU-111465] Apoptotic cleavage of cellular proteins - Mus musculus
[Pathway:R-RNO-111465] Apoptotic cleavage of cellular proteins - Rattus norvegicus
[Pathway:R-CFA-111465] Apoptotic cleavage of cellular proteins - Canis familiaris
[Pathway:R-BTA-111465] Apoptotic cleavage of cellular proteins - Bos taurus
[Pathway:R-SSC-111465] Apoptotic cleavage of cellular proteins - Sus scrofa
[Pathway:R-DRE-111465] Apoptotic cleavage of cellular proteins - Danio rerio
[Pathway:R-XTR-111465] Apoptotic cleavage of cellular proteins - Xenopus tropicalis
[Pathway:R-GGA-111465] Apoptotic cleavage of cellular proteins - Gallus gallus
[Pathway:R-DME-111465] Apoptotic cleavage of cellular proteins - Drosophila melanogaster
[Pathway:R-CEL-111465] Apoptotic cleavage of cellular proteins - Caenorhabditis elegans
releaseDate
2007年12月11日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:204051] Ranganathan, S, 2007年11月23日 00:10:26
revised
[InstanceEdit:350336] Matthews, L, 2008年05月18日 15:58:28
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-111465
summation
[Summation:204216] Apoptotic cell death is achieved by the caspase-mediated cl...
updateTrackers
[UpdateTracker:9787161] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v46:[updateIndirectRLE]
[UpdateTracker:9790988] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v32:[updateIndirectRLE]
[UpdateTracker:9792176] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v23:[addHasEvent, addLiteratureReference, addSummation]
[UpdateTracker:9789617] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v37:[updateIndirectRLE]
[UpdateTracker:9790365] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v33:[addHasEvent]
[UpdateTracker:9791771] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v26:[addHasEvent]
[UpdateTracker:9788057] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v44:[updateContainedRLE]
[UpdateTracker:9791930] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v24:[addHasEvent]
[UpdateTracker:9787372] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v45:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782266] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v59:[updateIndirectRLE]
[UpdateTracker:9779942] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v64:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9791660] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v28:[updateIndirectRLE]
[UpdateTracker:9791887] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v25:[add_removeHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-75153] Apoptotic execution phase
(updatedInstance)
[UpdateTracker:9787161] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v46:[updateIndirectRLE]
[UpdateTracker:9790988] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v32:[updateIndirectRLE]
[UpdateTracker:9792176] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v23:[addHasEvent, addLiteratureReference, addSummation]
[UpdateTracker:9789617] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v37:[updateIndirectRLE]
[UpdateTracker:9790365] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v33:[addHasEvent]
[UpdateTracker:9791771] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v26:[addHasEvent]
[UpdateTracker:9788057] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v44:[updateContainedRLE]
[UpdateTracker:9791930] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v24:[addHasEvent]
[UpdateTracker:9787372] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v45:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782266] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v59:[updateIndirectRLE]
[UpdateTracker:9779942] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v64:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9791660] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v28:[updateIndirectRLE]
[UpdateTracker:9791887] Update Tracker - [Pathway:111465] Apoptotic cleavage of cellular proteins - v25:[add_removeHasEvent]
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