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Go!
Schema
>
SimpleEntity
>
Entries
HS [extracellular region]
Show undefined attributes
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compartment
[Compartment:984] extracellular region
componentOf
[Complex:R-CEL-5654355] KAL1:HS [extracellular region] - Caenorhabditis elegans
[Complex:R-HSA-2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane] - Homo sapiens
[Complex:R-HSA-2065929] FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane] - Homo sapiens
[Complex:R-NUL-8853170] FGFR2 IIIa TM:FGF1,2:FGFR2b,c:HS [plasma membrane] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands - Homo sapiens
[Reaction:R-HSA-2033472] FGFR2c mutants bind an expanded range of ligands - Homo sapiens
[Reaction:R-CEL-5654511] FGFRL1 dimer binds FGFs - Caenorhabditis elegans
[Reaction:R-DME-5654511] FGFRL1 dimer binds FGFs - Drosophila melanogaster
[Reaction:R-GGA-5654511] FGFRL1 dimer binds FGFs - Gallus gallus
[Reaction:R-XTR-5654511] FGFRL1 dimer binds FGFs - Xenopus tropicalis
[Reaction:R-DRE-5654511] FGFRL1 dimer binds FGFs - Danio rerio
[Reaction:R-SSC-5654511] FGFRL1 dimer binds FGFs - Sus scrofa
[Reaction:R-BTA-5654511] FGFRL1 dimer binds FGFs - Bos taurus
[Reaction:R-CFA-5654511] FGFRL1 dimer binds FGFs - Canis familiaris
[Reaction:R-RNO-5654511] FGFRL1 dimer binds FGFs - Rattus norvegicus
[Reaction:R-HSA-5654511] FGFRL1 dimer binds FGFs - Homo sapiens
[Reaction:R-MMU-5654511] FGFRL1 dimer binds FGFs - Mus musculus
[Reaction:R-CEL-5654515] KAL1 binds HS - Caenorhabditis elegans
[Reaction:R-DME-5654515] KAL1 binds HS - Drosophila melanogaster
[Reaction:R-GGA-5654515] KAL1 binds HS - Gallus gallus
[Reaction:R-XTR-5654515] KAL1 binds HS - Xenopus tropicalis
[Reaction:R-DRE-5654515] KAL1 binds HS - Danio rerio
[Reaction:R-SSC-5654515] KAL1 binds HS - Sus scrofa
[Reaction:R-CFA-5654515] KAL1 binds HS - Canis familiaris
[Reaction:R-HSA-5654515] KAL1 binds HS - Homo sapiens
[BlackBoxEvent:R-CEL-190258] FGFR2c binds to FGF - Caenorhabditis elegans
[BlackBoxEvent:R-DME-190258] FGFR2c binds to FGF - Drosophila melanogaster
[BlackBoxEvent:R-GGA-190258] FGFR2c binds to FGF - Gallus gallus
[BlackBoxEvent:R-DRE-190258] FGFR2c binds to FGF - Danio rerio
[BlackBoxEvent:R-BTA-190258] FGFR2c binds to FGF - Bos taurus
[BlackBoxEvent:R-CFA-190258] FGFR2c binds to FGF - Canis familiaris
[BlackBoxEvent:R-RNO-190258] FGFR2c binds to FGF - Rattus norvegicus
[BlackBoxEvent:R-MMU-190258] FGFR2c binds to FGF - Mus musculus
[BlackBoxEvent:R-HSA-190258] FGFR2c binds to FGF - Homo sapiens
[Reaction:R-CEL-190265] FGFR4 binds to FGF - Caenorhabditis elegans
[Reaction:R-DME-190265] FGFR4 binds to FGF - Drosophila melanogaster
[Reaction:R-GGA-190265] FGFR4 binds to FGF - Gallus gallus
[Reaction:R-XTR-190265] FGFR4 binds to FGF - Xenopus tropicalis
[Reaction:R-DRE-190265] FGFR4 binds to FGF - Danio rerio
[Reaction:R-SSC-190265] FGFR4 binds to FGF - Sus scrofa
[Reaction:R-BTA-190265] FGFR4 binds to FGF - Bos taurus
[Reaction:R-CFA-190265] FGFR4 binds to FGF - Canis familiaris
[Reaction:R-RNO-190265] FGFR4 binds to FGF - Rattus norvegicus
[Reaction:R-MMU-190265] FGFR4 binds to FGF - Mus musculus
[Reaction:R-HSA-190265] FGFR4 binds to FGF - Homo sapiens
[Reaction:R-CEL-190256] FGFR1c binds to FGF - Caenorhabditis elegans
[Reaction:R-DME-190256] FGFR1c binds to FGF - Drosophila melanogaster
[Reaction:R-GGA-190256] FGFR1c binds to FGF - Gallus gallus
[Reaction:R-XTR-190256] FGFR1c binds to FGF - Xenopus tropicalis
[Reaction:R-DRE-190256] FGFR1c binds to FGF - Danio rerio
[Reaction:R-SSC-190256] FGFR1c binds to FGF - Sus scrofa
[Reaction:R-BTA-190256] FGFR1c binds to FGF - Bos taurus
[Reaction:R-CFA-190256] FGFR1c binds to FGF - Canis familiaris
[Reaction:R-RNO-190256] FGFR1c binds to FGF - Rattus norvegicus
[Reaction:R-MMU-190256] FGFR1c binds to FGF - Mus musculus
[Reaction:R-HSA-190256] FGFR1c binds to FGF - Homo sapiens
[Reaction:R-CEL-190245] FGFR1b binds to FGF - Caenorhabditis elegans
[Reaction:R-DME-190245] FGFR1b binds to FGF - Drosophila melanogaster
[Reaction:R-GGA-190245] FGFR1b binds to FGF - Gallus gallus
[Reaction:R-XTR-190245] FGFR1b binds to FGF - Xenopus tropicalis
[Reaction:R-DRE-190245] FGFR1b binds to FGF - Danio rerio
[Reaction:R-SSC-190245] FGFR1b binds to FGF - Sus scrofa
[Reaction:R-BTA-190245] FGFR1b binds to FGF - Bos taurus
[Reaction:R-CFA-190245] FGFR1b binds to FGF - Canis familiaris
[Reaction:R-RNO-190245] FGFR1b binds to FGF - Rattus norvegicus
[Reaction:R-MMU-190245] FGFR1b binds to FGF - Mus musculus
[Reaction:R-HSA-190245] FGFR1b binds to FGF - Homo sapiens
[Reaction:R-CEL-190268] FGFR1c binds to Klotho-bound FGF23 - Caenorhabditis elegans
[Reaction:R-DME-190268] FGFR1c binds to Klotho-bound FGF23 - Drosophila melanogaster
[Reaction:R-GGA-190268] FGFR1c binds to Klotho-bound FGF23 - Gallus gallus
[Reaction:R-XTR-190268] FGFR1c binds to Klotho-bound FGF23 - Xenopus tropicalis
[Reaction:R-DRE-190268] FGFR1c binds to Klotho-bound FGF23 - Danio rerio
[Reaction:R-SSC-190268] FGFR1c binds to Klotho-bound FGF23 - Sus scrofa
[Reaction:R-BTA-190268] FGFR1c binds to Klotho-bound FGF23 - Bos taurus
[Reaction:R-CFA-190268] FGFR1c binds to Klotho-bound FGF23 - Canis familiaris
[Reaction:R-RNO-190268] FGFR1c binds to Klotho-bound FGF23 - Rattus norvegicus
[Reaction:R-MMU-190268] FGFR1c binds to Klotho-bound FGF23 - Mus musculus
[Reaction:R-HSA-190268] FGFR1c binds to Klotho-bound FGF23 - Homo sapiens
[Reaction:R-CEL-190261] FGFR3c binds to FGF - Caenorhabditis elegans
[Reaction:R-DME-190261] FGFR3c binds to FGF - Drosophila melanogaster
[Reaction:R-GGA-190261] FGFR3c binds to FGF - Gallus gallus
[Reaction:R-DRE-190261] FGFR3c binds to FGF - Danio rerio
[Reaction:R-BTA-190261] FGFR3c binds to FGF - Bos taurus
[Reaction:R-CFA-190261] FGFR3c binds to FGF - Canis familiaris
[Reaction:R-RNO-190261] FGFR3c binds to FGF - Rattus norvegicus
[Reaction:R-MMU-190261] FGFR3c binds to FGF - Mus musculus
[Reaction:R-HSA-190261] FGFR3c binds to FGF - Homo sapiens
[Reaction:R-CEL-190263] FGFR3b binds to FGF - Caenorhabditis elegans
[Reaction:R-DME-190263] FGFR3b binds to FGF - Drosophila melanogaster
[Reaction:R-GGA-190263] FGFR3b binds to FGF - Gallus gallus
[Reaction:R-DRE-190263] FGFR3b binds to FGF - Danio rerio
[Reaction:R-BTA-190263] FGFR3b binds to FGF - Bos taurus
[Reaction:R-CFA-190263] FGFR3b binds to FGF - Canis familiaris
[Reaction:R-RNO-190263] FGFR3b binds to FGF - Rattus norvegicus
[Reaction:R-MMU-190263] FGFR3b binds to FGF - Mus musculus
[Reaction:R-HSA-190263] FGFR3b binds to FGF - Homo sapiens
[BlackBoxEvent:R-CEL-190260] FGFR2b binds to FGF - Caenorhabditis elegans
[BlackBoxEvent:R-DME-190260] FGFR2b binds to FGF - Drosophila melanogaster
[BlackBoxEvent:R-GGA-190260] FGFR2b binds to FGF - Gallus gallus
[BlackBoxEvent:R-DRE-190260] FGFR2b binds to FGF - Danio rerio
[BlackBoxEvent:R-BTA-190260] FGFR2b binds to FGF - Bos taurus
[BlackBoxEvent:R-CFA-190260] FGFR2b binds to FGF - Canis familiaris
[BlackBoxEvent:R-RNO-190260] FGFR2b binds to FGF - Rattus norvegicus
[BlackBoxEvent:R-MMU-190260] FGFR2b binds to FGF - Mus musculus
[BlackBoxEvent:R-HSA-190260] FGFR2b binds to FGF - Homo sapiens
[Reaction:R-HSA-2012074] FGFR3c P250R mutant binds to ligand with enhanced affinity - Homo sapiens
[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity - Homo sapiens
[Reaction:R-CEL-1307955] FGFR4 binds HS:KLB:FGF19 - Caenorhabditis elegans
[Reaction:R-DME-1307955] FGFR4 binds HS:KLB:FGF19 - Drosophila melanogaster
[Reaction:R-GGA-1307955] FGFR4 binds HS:KLB:FGF19 - Gallus gallus
[Reaction:R-XTR-1307955] FGFR4 binds HS:KLB:FGF19 - Xenopus tropicalis
[Reaction:R-SSC-1307955] FGFR4 binds HS:KLB:FGF19 - Sus scrofa
[Reaction:R-BTA-1307955] FGFR4 binds HS:KLB:FGF19 - Bos taurus
[Reaction:R-CFA-1307955] FGFR4 binds HS:KLB:FGF19 - Canis familiaris
[Reaction:R-RNO-1307955] FGFR4 binds HS:KLB:FGF19 - Rattus norvegicus
[Reaction:R-MMU-1307955] FGFR4 binds HS:KLB:FGF19 - Mus musculus
[Reaction:R-HSA-1307955] FGFR4 binds HS:KLB:FGF19 - Homo sapiens
[Reaction:R-NUL-8853328] Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors - Homo sapiens
[Reaction:R-HSA-8853320] FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling - Homo sapiens
created
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
dbId
190915
displayName
HS [extracellular region]
inDisease
false
isRequired
[Requirement:R-HSA-190311] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190318] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-1307970] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190313] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190314] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190316] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190319] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190317] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190312] Requirement by 'HS [extracellular region]'
maxDepth
1
modified
[InstanceEdit:9619952] Wu, G, 2018年09月19日
name
HS
Heparan Sulphate
heparan sulfate
positivelyRegulates
[PositiveRegulation:R-HSA-204490] Positive regulation by 'HS [extracellular region]'
[Requirement:R-HSA-190311] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190318] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-1307970] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190313] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190314] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190316] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190319] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190317] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190312] Requirement by 'HS [extracellular region]'
referenceEntity
[ReferenceMolecule:chebi:28815] heparan sulfate [ChEBI:28815]
referenceType
ReferenceMolecule
schemaClass
SimpleEntity
stId
R-ALL-190915
updateTrackers
[UpdateTracker:9889443] Update Tracker - [SimpleEntity:190915] HS [extracellular region] - v49:[addName]
[UpdateTracker:9891924] Update Tracker - [SimpleEntity:190915] HS [extracellular region] - v52:[addName]
Referrals
(hasComponent)
[Complex:R-NUL-8853170] FGFR2 IIIa TM:FGF1,2:FGFR2b,c:HS [plasma membrane]
[Complex:R-HSA-8853189] FGFR2IIIa TM:FGF1,2:FGFR2b, FGFR2c [plasma membrane]
[Complex:R-HSA-2065929] FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
[Complex:R-HSA-2065986] FGFR2c mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]
[Complex:R-HSA-2065989] Activated FGFR2c mutants with enhanced ligand-binding [plasma membrane]
[Complex:R-HSA-2065931] Activated FGFR2b mutants with enhanced ligand binding [plasma membrane]
[Complex:R-HSA-2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane]
[Complex:R-HSA-2011989] Activated FGFR3c P250R mutant [plasma membrane]
[Complex:R-HSA-2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]
[Complex:R-HSA-2050642] Activated FGFR1c P252X mutants [plasma membrane]
[Complex:R-XTR-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-CFA-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-DRE-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-SSC-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-GGA-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-CEL-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-RNO-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-BTA-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-DME-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-HSA-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-MMU-5654354] FGFRL1-binding FGFs:FGFRL1 dimer [plasma membrane]
[Complex:R-XTR-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-SSC-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-MMU-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-BTA-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-CFA-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-CEL-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-RNO-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-GGA-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-DME-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-HSA-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
[Complex:R-DME-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-SSC-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-XTR-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190223] FGFR4 homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-5654355] KAL1:HS [extracellular region]
[Complex:R-DRE-5654355] KAL1:HS [extracellular region]
[Complex:R-DME-5654355] KAL1:HS [extracellular region]
[Complex:R-GGA-5654355] KAL1:HS [extracellular region]
[Complex:R-SSC-5654355] KAL1:HS [extracellular region]
[Complex:R-XTR-5654355] KAL1:HS [extracellular region]
[Complex:R-CFA-5654355] KAL1:HS [extracellular region]
[Complex:R-HSA-5654355] KAL1:HS [extracellular region]
[Complex:R-BTA-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-DME-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-SSC-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-XTR-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190233] FGFR1c homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-SSC-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-DME-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-XTR-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190226] FGFR1b homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-CEL-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-RNO-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-XTR-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-DME-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-GGA-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-DRE-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-SSC-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-CFA-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-BTA-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-HSA-190218] FGF23 bound to Klotho and FGFR1c [plasma membrane]
[Complex:R-DRE-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-DME-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190234] FGFR3c homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-DME-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190232] FGFR3b homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-DME-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-192609] FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-DME-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190225] FGFR2c long homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-DME-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-192591] FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-DME-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190227] FGFR2b long homodimer bound to FGF [plasma membrane]
[Complex:R-DME-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-SSC-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-RNO-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-BTA-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-DRE-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-MMU-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-XTR-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-GGA-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-CEL-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-CFA-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-HSA-190328] Activated FGFR4 homodimer [plasma membrane]
[Complex:R-SSC-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-CEL-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-DRE-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-CFA-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-MMU-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-DME-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-GGA-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-XTR-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-BTA-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-RNO-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-HSA-190430] Activated FGFR1b homodimer [plasma membrane]
[Complex:R-CEL-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-DME-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-RNO-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-DRE-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-XTR-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-SSC-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-BTA-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-CFA-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-MMU-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-GGA-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-HSA-190425] Activated FGFR1c homodimer [plasma membrane]
[Complex:R-DME-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-CFA-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-MMU-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-DRE-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-GGA-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-SSC-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-BTA-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-XTR-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-RNO-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-CEL-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-HSA-500333] Activated FGFR1c bound to FGF23:Klotho [plasma membrane]
[Complex:R-CFA-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-DRE-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-MMU-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-CEL-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-DME-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-GGA-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-RNO-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-BTA-190411] Activated FGFR2b long homodimer [plasma membrane]
[Complex:R-HSA-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-DME-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-CFA-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-GGA-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-MMU-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-CEL-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-RNO-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-BTA-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-DRE-190389] Activated FGFR3c homodimer [plasma membrane]
[Complex:R-HSA-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-DRE-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-CFA-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-CEL-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-GGA-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-DME-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-MMU-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-BTA-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-RNO-190380] Activated FGFR3b homodimer [plasma membrane]
[Complex:R-HSA-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-BTA-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-RNO-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-DRE-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-CFA-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-CEL-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-MMU-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-GGA-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-DME-190418] Activated FGFR2c long homodimer [plasma membrane]
[Complex:R-HSA-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-DME-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-192592] Activated FGFR2c short homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-CFA-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-BTA-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-GGA-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-DME-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-MMU-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-DRE-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-RNO-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-CEL-192597] Activated FGFR2b short homodimer bound to FGF [plasma membrane]
[Complex:R-HSA-190411] Activated FGFR2b long homodimer [plasma membrane]
(input)
[Reaction:R-NUL-8853328] Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors
[Reaction:R-HSA-8853320] FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling
[Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands
[Reaction:R-HSA-2033472] FGFR2c mutants bind an expanded range of ligands
[Reaction:R-HSA-2012074] FGFR3c P250R mutant binds to ligand with enhanced affinity
[Reaction:R-HSA-2023451] FGFR1c P252X mutants bind ligand with enhanced affinity
[Reaction:R-CEL-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-DME-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-GGA-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-XTR-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-DRE-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-SSC-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-BTA-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-CFA-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-RNO-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-HSA-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-MMU-5654511] FGFRL1 dimer binds FGFs
[Reaction:R-CEL-5654515] KAL1 binds HS
[Reaction:R-DME-5654515] KAL1 binds HS
[Reaction:R-GGA-5654515] KAL1 binds HS
[Reaction:R-XTR-5654515] KAL1 binds HS
[Reaction:R-DRE-5654515] KAL1 binds HS
[Reaction:R-SSC-5654515] KAL1 binds HS
[Reaction:R-CFA-5654515] KAL1 binds HS
[Reaction:R-HSA-5654515] KAL1 binds HS
[Reaction:R-CEL-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-DME-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-GGA-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-XTR-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-SSC-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-BTA-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-CFA-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-RNO-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-MMU-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-HSA-1307955] FGFR4 binds HS:KLB:FGF19
[Reaction:R-CEL-190265] FGFR4 binds to FGF
[Reaction:R-DME-190265] FGFR4 binds to FGF
[Reaction:R-GGA-190265] FGFR4 binds to FGF
[Reaction:R-XTR-190265] FGFR4 binds to FGF
[Reaction:R-DRE-190265] FGFR4 binds to FGF
[Reaction:R-SSC-190265] FGFR4 binds to FGF
[Reaction:R-BTA-190265] FGFR4 binds to FGF
[Reaction:R-CFA-190265] FGFR4 binds to FGF
[Reaction:R-RNO-190265] FGFR4 binds to FGF
[Reaction:R-MMU-190265] FGFR4 binds to FGF
[Reaction:R-HSA-190265] FGFR4 binds to FGF
[Reaction:R-CEL-190256] FGFR1c binds to FGF
[Reaction:R-DME-190256] FGFR1c binds to FGF
[Reaction:R-GGA-190256] FGFR1c binds to FGF
[Reaction:R-XTR-190256] FGFR1c binds to FGF
[Reaction:R-DRE-190256] FGFR1c binds to FGF
[Reaction:R-SSC-190256] FGFR1c binds to FGF
[Reaction:R-BTA-190256] FGFR1c binds to FGF
[Reaction:R-CFA-190256] FGFR1c binds to FGF
[Reaction:R-RNO-190256] FGFR1c binds to FGF
[Reaction:R-MMU-190256] FGFR1c binds to FGF
[Reaction:R-HSA-190256] FGFR1c binds to FGF
[Reaction:R-CEL-190245] FGFR1b binds to FGF
[Reaction:R-DME-190245] FGFR1b binds to FGF
[Reaction:R-GGA-190245] FGFR1b binds to FGF
[Reaction:R-XTR-190245] FGFR1b binds to FGF
[Reaction:R-DRE-190245] FGFR1b binds to FGF
[Reaction:R-SSC-190245] FGFR1b binds to FGF
[Reaction:R-BTA-190245] FGFR1b binds to FGF
[Reaction:R-CFA-190245] FGFR1b binds to FGF
[Reaction:R-RNO-190245] FGFR1b binds to FGF
[Reaction:R-MMU-190245] FGFR1b binds to FGF
[Reaction:R-HSA-190245] FGFR1b binds to FGF
[Reaction:R-CEL-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-DME-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-GGA-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-XTR-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-DRE-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-SSC-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-BTA-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-CFA-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-RNO-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-MMU-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-HSA-190268] FGFR1c binds to Klotho-bound FGF23
[Reaction:R-CEL-190261] FGFR3c binds to FGF
[Reaction:R-DME-190261] FGFR3c binds to FGF
[Reaction:R-GGA-190261] FGFR3c binds to FGF
[Reaction:R-DRE-190261] FGFR3c binds to FGF
[Reaction:R-BTA-190261] FGFR3c binds to FGF
[Reaction:R-CFA-190261] FGFR3c binds to FGF
[Reaction:R-RNO-190261] FGFR3c binds to FGF
[Reaction:R-MMU-190261] FGFR3c binds to FGF
[Reaction:R-HSA-190261] FGFR3c binds to FGF
[Reaction:R-CEL-190263] FGFR3b binds to FGF
[Reaction:R-DME-190263] FGFR3b binds to FGF
[Reaction:R-GGA-190263] FGFR3b binds to FGF
[Reaction:R-DRE-190263] FGFR3b binds to FGF
[Reaction:R-BTA-190263] FGFR3b binds to FGF
[Reaction:R-CFA-190263] FGFR3b binds to FGF
[Reaction:R-RNO-190263] FGFR3b binds to FGF
[Reaction:R-MMU-190263] FGFR3b binds to FGF
[Reaction:R-HSA-190263] FGFR3b binds to FGF
[BlackBoxEvent:R-CEL-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-DME-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-GGA-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-DRE-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-BTA-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-CFA-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-RNO-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-MMU-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-HSA-190258] FGFR2c binds to FGF
[BlackBoxEvent:R-CEL-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-DME-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-GGA-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-DRE-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-BTA-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-CFA-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-RNO-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-MMU-190260] FGFR2b binds to FGF
[BlackBoxEvent:R-HSA-190260] FGFR2b binds to FGF
(regulator)
[PositiveRegulation:R-HSA-204490] Positive regulation by 'HS [extracellular region]'
[Requirement:R-HSA-190311] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190318] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-1307970] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190313] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190314] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190316] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190319] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190317] Requirement by 'HS [extracellular region]'
[Requirement:R-HSA-190312] Requirement by 'HS [extracellular region]'
(updatedInstance)
[UpdateTracker:9889443] Update Tracker - [SimpleEntity:190915] HS [extracellular region] - v49:[addName]
[UpdateTracker:9891924] Update Tracker - [SimpleEntity:190915] HS [extracellular region] - v52:[addName]
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