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FGFR2b mutants bind an expanded range of ligands Show undefined attributes

authored

[InstanceEdit:2105031] Rothfels, K, 2012年02月09日

category binding

compartment

created [InstanceEdit:2033475] Rothfels, K, 2012年01月09日

crossReference

dbId 2033474

disease

displayName FGFR2b mutants bind an expanded range of ligands

edited

[InstanceEdit:2252592] Rothfels, K, 2012年05月16日

entityFunctionalStatus

[EntityFunctionalStatus:5654518] gain_of_function of FGFR2b mutants with enhanced ligand binding [plasma membrane]

eventOf

[Pathway:R-HSA-2033519] Activated point mutants of FGFR2 - Homo sapiens

followingEvent

[Reaction:R-HSA-2033488] Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

FGFR2b mutants bind an expanded range of ligands
FGFR2b somatic mutants bind an expanded range of ligands

output

[Complex:R-HSA-2065929] FGFR2b mutant dimers with enhanced ligand-binding bound to FGFs [plasma membrane]

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2248845] Ezzat, S, 2012年05月15日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2033474

summation

[Summation:2060304] Apert sydrome is the most severe of the craniosynostosis syn...

Referrals

(precedingEvent)

[Reaction:R-HSA-2033488] Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding

(hasEvent)

[Pathway:R-HSA-2033519] Activated point mutants of FGFR2

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