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FGFR3c P250R mutant binds to ligand with enhanced affinity Show undefined attributes

authored

[InstanceEdit:2105031] Rothfels, K, 2012年02月09日

category binding

compartment

created [InstanceEdit:2012075] Rothfels, K, 2011年11月22日

crossReference

dbId 2012074

disease

displayName FGFR3c P250R mutant binds to ligand with enhanced affinity

edited

[InstanceEdit:2252592] Rothfels, K, 2012年05月16日

entityFunctionalStatus

[EntityFunctionalStatus:5654524] gain_of_function of FGFR3c P250R [plasma membrane]

eventOf

[Pathway:R-HSA-1839130] Signaling by activated point mutants of FGFR3 - Homo sapiens

followingEvent

[Reaction:R-HSA-2012073] Autocatalytic phosphorylation of FGFR3c P250R mutant - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

FGFR3c P250R mutant binds to ligand with enhanced affinity

output

[Complex:R-HSA-2011952] FGFR3c P250R mutant dimer bound to FGF [plasma membrane]

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2248845] Ezzat, S, 2012年05月15日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2012074

summation

[Summation:2064375] FGFR3 P350R is associated with the development of Muenke syn...

Referrals

(precedingEvent)

[Reaction:R-HSA-2012073] Autocatalytic phosphorylation of FGFR3c P250R mutant

(hasEvent)

[Pathway:R-HSA-1839130] Signaling by activated point mutants of FGFR3

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