Reactome Pathway Database

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Rhea:21292 Show undefined attributes

databaseName Rhea

dbId 12610421

displayName Rhea:21292

identifier 21292

referenceDatabase [ReferenceDatabase:12610418] Rhea

schemaClass DatabaseIdentifier

url https://www.rhea-db.org/rhea/21292

Referrals

(crossReference)

[Reaction:R-HSA-9680389] CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2
[Reaction:R-HSA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3
[BlackBoxEvent:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides
[Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3
[Reaction:R-HSA-2029271] PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
[Reaction:R-HSA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
[Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
[Reaction:R-HSA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
[Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K
[Reaction:R-HSA-8852019] MET bound PI3K generates PIP3
[Reaction:R-HSA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
[Reaction:R-HSA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
[Reaction:R-HSA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3
[Reaction:R-HSA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-2424480] PI3K phosphorylates PIP2 to PIP3
[BlackBoxEvent:R-HSA-9603445] Activated NTRK3 stimulates PI3K activity
[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K
[Reaction:R-HSA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3
[Reaction:R-HSA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
[Reaction:R-HSA-9860816] Phospho-PI3K in p-Y713-PECAM1:CDH5:PIK3CA,B,D:p-Y464-PIK3R2:p-Y801,Y1054,Y1175-KDR:p-Y1063,Y1230-FLT4:CTNNB1 phosphorylates phosphoinositol-4,5-bisphosphate to yield phosphoinositol-3,4,5-trisphosphate
[BlackBoxEvent:R-HSA-9028519] NTRK2-activated PI3K generates PIP3
[Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants
[Reaction:R-HSA-9672162] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers
[Reaction:R-HSA-5655289] Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3
[Reaction:R-HSA-5655323] Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3
[Reaction:R-HSA-9672177] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR
[Reaction:R-HSA-9670433] KIT mutants:PI3K catalyze synthesis of PIP3
[Reaction:R-HSA-5637801] Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII
[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK
[Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-2394007] PI3K gain of function mutants phosphorylate PIP2 to PIP3
[Reaction:R-HSA-9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3
[Reaction:R-HSA-9712084] PI3K synthesizes PIP3 downstream of ALK mutants
[Reaction:R-HSA-5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3

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