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Schema
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Reaction
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Entries
KIT mutants:PI3K catalyze synthesis of PIP3
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authored
[InstanceEdit:9681395] Rothfels, Karen, 2020年04月01日
catalystActivity
[CatalystActivity:9670406] 1-phosphatidylinositol-3-kinase activity of PI3K:p-KIT mutant dimers [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:9670432] Rothfels, Karen, 2019年12月09日
crossReference
[DatabaseIdentifier:12610421] Rhea:21292
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9670433
disease
[Disease:1500689] cancer
displayName
KIT mutants:PI3K catalyze synthesis of PIP3
edited
[InstanceEdit:9686618] Rothfels, Karen, 2020年05月04日
entityFunctionalStatus
[EntityFunctionalStatus:9670395] gain_of_function of PI3K:p-KIT mutant dimers [plasma membrane]
eventOf
[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9669213] KIT mutations are common in testicular seminomas
[LiteratureReference:9669177] KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors
[LiteratureReference:9680307] KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway
[LiteratureReference:9680303] Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
[LiteratureReference:9680542] Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms
[LiteratureReference:9680290] Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor
[LiteratureReference:9669094] Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours
[LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
KIT mutants:PI3K catalyze synthesis of PIP3
normalReaction
[Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent
[Reaction:R-HSA-9670431] Phosphorylated KIT mutants bind PI3K - Homo sapiens
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9678239] Serrano, C駸ar, 2020年03月13日
[InstanceEdit:9678232] Garc?a-Valverde, Alfonso, 2020年03月13日
[InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020年03月13日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9670433
summation
[Summation:9670511] PI3K/AKT signaling is initiated downstream of KIT juxtamembr...
Referrals
(hasEvent)
[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
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