Potassium channel gene expression in the rat cochlear nucleus

@article{Friedland2007PotassiumCG,
 title={Potassium channel gene expression in the rat cochlear nucleus},
 author={David R. Friedland and Rebecca Eernisse and Paul Popper},
 journal={Hearing Research},
 year={2007},
 volume={228},
 pages={31-43},
 url={https://api.semanticscholar.org/CorpusID:2519176}
}

18 Citations

Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity
It is shown that in mice, Kcns1 is predominantly expressed in the cell body and axons of myelinated sensory neurons positive for neurofilament-200, including A&dgr;-fiber nociceptors and low-threshold A&bgr; mechanoreceptors and in the spinal cord, where most sensory A fibers terminate.

Functional Development of Principal Neurons in the Anteroventral Cochlear Nucleus Extends Beyond Hearing Onset
The data suggest that maturation of auditory processing in the parallel ascending BC and SC streams engages distinct mechanisms at the first central synapses that may differently depend on the early auditory experience.

Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway
The possible contribution of select potassium ion channels in the cochlea and auditory pathway to ARHL is reviewed and postulate genes, proteins, or modulators that contribute to sustained ion currents or proper surface expressions of potassium channels under challenging conditions as key for future therapies of ARHL.

Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus
The main endogenous role of NO seems to be to partly suppress driven firing rates associated with NMDA channel activity but there is scope for it to increase neural gain if there were a pathological increase in its production following hearing loss.

ATP-sensitive K+ channels control the spontaneous firing of a glycinergic interneuron in the auditory brainstem
It is found that quiet neurons express an outward conductance not seen in active neurons, which generates a stable resting potential, and changes in KATP channel activity of cartwheel neurons can be related to the DCN hyperactivity seen in tinnitus.

Context-dependent effects of NMDA receptors on precise timing information at the endbulb of Held in the cochlear nucleus.
Mature NMDAR expression can support the conveying of precise temporal information at the endbulb, depending on the stimulus conditions, including AMPAR-mediated excitatory postsynaptic currents with fast kinetics.

44 References

Localization of a high threshold potassium channel in the rat cochlear nucleus
The pattern of immunolabeling revealed that the Kv3.1 protein is distributed along the soma, proximal dendrites, unmyelinated axons, and axon terminals of stained neurons, which enhances the ability of a model cell with some of the features of bushy cells to follow high frequency input with temporal precision.

Localization of two high‐threshold potassium channel subunits in the rat central auditory system
Results suggest that KV3.3 channels may be the dominant Kv3 subfamily member expressed in brainstem auditory neurons and that, in some auditory neurons, Kv1.1 and Kv2.3 may coassemble to form functional channels.

Differential expression of three distinct potassium currents in the ventral cochlear nucleus.
A surprising finding was the wide range of levels of ILT, suggesting ILT is expressed as a continuum across cell types rather than modally in a particular cell type.

Differential expression of Shaw-related K+ channels in the rat central nervous system
The studies presented here provide important clues for the identification of native homo- and heteromULTimeric ShIII channels in neurons and suggest that heteromultimer formation between ShIII proteins might be a common feature in the CNS.

Decreased Temporal Precision of Auditory Signaling in Kcna1-Null Mice: An Electrophysiological Study In Vivo
Results indicate that in Kcna1-null mice the absence of the Kv1.1 subunit results in a loss of temporal fidelity (increased jitter) and the failure to follow high-frequency amplitude-modulated sound stimulation in vivo.

Distribution and functional properties of human KCNH8 (Elk1) potassium channels.
Quantitative RT-PCR analysis of mRNA expression patterns showed that KCNH8, along with the other Elk family genes, KCNH3 and KCNH4, are primarily expressed in the human nervous system, and thatKCNH8 subunits are not able to form heteromultimers with Eag, Erg, or Kv family K+ channels.

The roles potassium currents play in regulating the electrical activity of ventral cochlear nucleus neurons.
Simulated Type II cells have a significantly faster membrane time constant in comparison to Type I cells (stellate cells) and are therefore better suited to preserve temporal information in their auditory nerve inputs by acting as precise coincidence detectors and having a short refractory period.

CNS Distribution of Members of the Two-Pore-Domain (KCNK) Potassium Channel Family
The differential expression of each two-pore-domain K+ channel family member likely contributes to characteristic excitability properties in distinct populations of neurons, as well as to diversity in their susceptibility to modulation.