Cloning and Functional Characterization of Novel Large Conductance Calcium-activated Potassium Channel β Subunits, hKCNMB3 and hKCNMB4*
- R. Brenner T. Jegla A. Wickenden Yi Liu R. Aldrich
- 3 March 2000
Biology
The cloning and characterization of two novel calcium-activated potassium channel β subunits that are enriched in the testis and brain are presented, and it is found that the different effects of the β subunit on some Hslo1 channel properties are calcium-dependent.
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
- A. Wickenden Weifeng Yu Anrou Zou T. Jegla P. Wagoner
- 1 September 2000
Medicine
It is suggested that activation of KCNQ2/Q3 channels may be responsible for at least some of the anticonvulsant activity of this agent.
Stoichiometry of Expressed KCNQ2/KCNQ3 Potassium Channels and Subunit Composition of Native Ganglionic M Channels Deduced from Block by Tetraethylammonium
- J. Hadley G. Passmore D. Brown
- 15 June 2003
Biology
It is concluded that coexpressed KCNZ2 plus KCNQ3 cDNAs generate channels with 1:1 (KCNQ2:KCNZ3) stoichiometry in CHO cells and that native M channels in SCG neurons adopt the same conformation during development, assisted by the increased expression of KCN Q3 mRNA and protein.
N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator
- A. Wickenden J. Krajewski G. Rigdon
- 1 March 2008
Chemistry, Medicine
ICA-27243 represents the first member of a novel chemical class of selective KCNQ2/Q3 activators with anticonvulsant-like activity in experimental models of epilepsy.
Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567
- A. Bhattacharya Qi Wang M. Letavic
- 1 October 2013
Medicine
JNJ‐47965567 is characterized, a centrally permeable, high‐affinity, selective P2X7 antagonist, which may play a key role in neuropsychiatry, neurodegeneration and chronic pain.
Effects of Development and Thyroid Hormone on K+ Currents and K+ Channel Gene Expression in Rat Ventricle
- A. Wickenden R. Kaprielian T. Parker O. Jones P. Backx
- 1 October 1997
Medicine, Biology
It is shown that postnatal development involves a shortening of action potential duration and an increase in the density of ITO, and it is proposed that these functional effects occur as a consequence of the previously reported developmental Kv1.2/Kv4.3 isoform switch.
Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells
- A. Wickenden A. Zou P. Wagoner T. Jegla
- 1 January 2001
Biology, Medicine
The sensitivity of KCNQ5/Q3 channels to linopirdine supports the possibility that potassium channels comprised of KCnQ5 and KCNNQ3 may make a contribution to native M‐currents.
Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle.
- A. Wickenden T. Jegla R. Kaprielian Peter H Backx
- 1 May 1999
Biology, Medicine
The results show that I to is composed of both rapidly and slowly recovering components in the right wall and septum, and regionally specific differences in the genetic composition of I to can account for the region-specific properties of this current.
The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site
- Karen M. Padilla A. Wickenden A. Gerlach K. McCormack
- 13 November 2009
Biology, Chemistry
Activation of TRPA1 by Farnesyl Thiosalicylic Acid
- M. Maher Hong Ao A. Wickenden
- 1 April 2008
Chemistry, Medicine
Several compounds are discovered that possess potent, selective TRPA1-activating activity, including several lipid compounds, and it is shown that the mechanism of action of farnesyl thiosalicylic acid differs from that of the reactive electrophilic reagent allylisothiocyanate.
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