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PASK

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
For the airport in Alaska with ICAO code PASK, see Selawik Airport.
PASK
Available structures
PDB Ortholog search: PDBe RCSB
List of PDB id codes

1LL8, 3DLS

Identifiers
Aliases PASK , PASKIN, STK37, PAS domain containing serine/threonine kinase
External IDsOMIM: 607505; MGI: 2155936; HomoloGene: 9038; GeneCards: PASK; OMA:PASK - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human) [1]
Band 2q37.3Start241,106,099 bp [1]
End241,150,264 bp [1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr. Chromosome 1 (mouse)[2]
Band 1|1 DStart93,236,492 bp [2]
End93,271,204 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • right uterine tube

  • oocyte

  • right testis

  • left testis

  • secondary oocyte

  • lymph node

  • appendix

  • caudate nucleus

  • putamen

  • nucleus accumbens
  • spermatocyte

  • spermatid

  • otic vesicle

  • otic placode

  • saccule

  • seminiferous tubule

  • epiblast

  • ventricular zone

  • tail of embryo

  • gastrula
More reference expression data
BioGPS


Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23178

269224

Ensembl

ENSG00000115687

ENSMUSG00000026274

UniProt

Q96RG2

Q8CEE6

RefSeq (mRNA)

NM_001252119
NM_001252120
NM_001252122
NM_001252124
NM_015148

NM_080850

RefSeq (protein)

NP_001239048
NP_001239049
NP_001239051
NP_001239053
NP_055963

NP_543126

Location (UCSC)Chr 2: 241.11 – 241.15 Mb Chr 1: 93.24 – 93.27 Mb
PubMed search[3] [4]
Wikidata

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.[5] [6] [7] [8]

PAS domains regulate the function of many intracellular signaling pathways in response to both extrinsic and intrinsic stimuli. PASK is an evolutionarily conserved protein present in yeast, flies, and mammals.[supplied by OMIM][8]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115687Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026274Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hofer T, Spielmann P, Stengel P, Stier B, Katschinski DM, Desbaillets I, Gassmann M, Wenger RH (Nov 2001). "Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors" (PDF). Biochem Biophys Res Commun. 288 (4): 757–64. Bibcode:2001BBRC..288..757H. doi:10.1006/bbrc.2001.5840. PMID 11688972. Archived from the original (PDF) on 2013年11月02日. Retrieved 2018年12月22日.
  6. ^ Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL (Aug 2001). "PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase". Proc Natl Acad Sci U S A. 98 (16): 8991–6. Bibcode:2001PNAS...98.8991R. doi:10.1073/pnas.161284798 . PMC 55361 . PMID 11459942.
  7. ^ da Silva Xavier G, Rutter J, Rutter GA (Jun 2004). "Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose". Proc Natl Acad Sci U S A. 101 (22): 8319–24. Bibcode:2004PNAS..101.8319D. doi:10.1073/pnas.0307737101 . PMC 420392 . PMID 15148392.
  8. ^ a b "Entrez Gene: PASK PAS domain containing serine/threonine kinase".

Further reading

[edit ]
PDB gallery
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K


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