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MAST2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MAST2
Available structures
PDB Ortholog search: PDBe RCSB
List of PDB id codes

2KQF, 2KYL

Identifiers
Aliases MAST2 , MAST205, MTSSK, microtubule associated serine/threonine kinase 2
External IDsOMIM: 612257; MGI: 894676; HomoloGene: 7428; GeneCards: MAST2; OMA:MAST2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human) [1]
Band 1p34.1Start45,786,987 bp [1]
End46,036,122 bp [1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr. Chromosome 4 (mouse)[2]
Band 4|4 D1Start116,306,762 bp [2]
End116,464,183 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • gastrocnemius muscle

  • muscle of thigh

  • apex of heart

  • gastric mucosa

  • glutes

  • stromal cell of endometrium

  • pancreatic ductal cell

  • skeletal muscle tissue

  • left ventricle

  • left testis
  • neural layer of retina

  • muscle of thigh

  • internal carotid artery

  • right ventricle

  • ankle joint

  • cardiac muscle tissue of left ventricle

  • external carotid artery

  • ankle

  • digastric muscle

  • soleus muscle
More reference expression data
BioGPS




Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23139

17776

Ensembl

ENSG00000086015

ENSMUSG00000003810

UniProt

Q6P0Q8

Q60592

RefSeq (mRNA)

NM_015112
NM_001319245
NM_001324320
NM_001324321

NM_001042743
NM_008641
NM_001369061
NM_001369062

RefSeq (protein)

NP_001306174
NP_001311249
NP_001311250
NP_055927

NP_001036208
NP_032667
NP_001355990
NP_001355991

Location (UCSC)Chr 1: 45.79 – 46.04 Mb Chr 4: 116.31 – 116.46 Mb
PubMed search[3] [4]
Wikidata

Microtubule-associated serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MAST2 gene.[5] The protein encoded by this gene controls TRAF6 and NF-kappaB activity.[6]

Interactions

[edit ]

MAST2 has been shown to interact with PCLKC.[7]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086015Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003810Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MAST2 microtubule associated serine/threonine kinase 2".
  6. ^ Xiong H, Li H, Chen Y, Zhao J, Unkeless JC (2004). "Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability". J. Biol. Chem. 279 (42): 43675–83. doi:10.1074/jbc.M404328200 . PMID 15308666.
  7. ^ Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (July 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139 . PMID 12117771.

Further reading

[edit ]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K

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