Zinc finger FYVE domain-containing protein 9
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Protein found in humans
| ZFYVE9 | |||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ZFYVE9 , MADHIP, NSP, PPP1R173, SARA, SMADIP, zinc finger FYVE-type containing 9 | ||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603755; MGI: 2652838; HomoloGene: 3527; GeneCards: ZFYVE9; OMA:ZFYVE9 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||
Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.[5] SARA contains a double zinc finger (FYVE domain).
SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.[6] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.
References
[edit ]- ^ a b c GRCh38: Ensembl release 89: ENSG00000157077 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034557 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell. 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8 . PMID 9865696. S2CID 6194655.
- ^ Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature. 431 (7005): 205–211. Bibcode:2004Natur.431..205L. doi:10.1038/nature02783. PMID 15356634. S2CID 4301789.
External links
[edit ]- PDBe-KB provides an overview of all the structure information available in the PDB for Human Zinc finger FYVE domain-containing protein 9
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