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Latent TGF-beta binding protein

From Wikipedia, the free encyclopedia
Family of carrier proteins

The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.[1] [2]

LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.

Genes

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latent transforming growth factor beta binding protein 1
Identifiers
SymbolLTBP1
Alt. symbolsTGF-beta1-BP-1
NCBI gene 4052
HGNC 6714
OMIM 150390
RefSeq NM_206943
UniProt Q14766
Other data
Locus Chr. 2 p22-p21
Search for
StructuresSwiss-model
DomainsInterPro
latent transforming growth factor beta binding protein 2
Identifiers
SymbolLTBP2
Alt. symbolsLTBP3, C14orf141
NCBI gene 4053
HGNC 6715
OMIM 602091
RefSeq NM_000428
UniProt Q14767
Other data
Locus Chr. 14 q24.3
Search for
StructuresSwiss-model
DomainsInterPro
latent transforming growth factor beta binding protein 3
Identifiers
SymbolLTBP3
Alt. symbolsLTBP2
NCBI gene 4054
HGNC 6716
OMIM 602090
RefSeq NM_021070
UniProt Q9NS15
Other data
Locus Chr. 11 q12
Search for
StructuresSwiss-model
DomainsInterPro
latent transforming growth factor beta binding protein 4
Identifiers
SymbolLTBP4
Alt. symbolsLTBP-4, LTBP-4L
NCBI gene 8425
HGNC 6717
OMIM 604710
RefSeq NM_003573
UniProt Q8N2S1
Other data
Locus Chr. 19 q13.1-13.2
Search for
StructuresSwiss-model
DomainsInterPro

References

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  1. ^ Rifkin DB (March 2005). "Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability". J. Biol. Chem. 280 (9): 7409–12. doi:10.1074/jbc.R400029200 . PMID 15611103.
  2. ^ Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB (January 2005). "Latent TGF-beta binding proteins". Int. J. Biochem. Cell Biol. 37 (1): 38–41. doi:10.1016/j.biocel.2004年03月01日1. PMID 15381147.
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Fatty acid
Hormone
Metal/element
Vitamin
Pigment
Other
TGF beta superfamily of ligands
Ligand of ACVR or TGFBR
Ligand of BMPR
TGF beta receptors
(Activin, BMP, family)
TGFBR1:
TGFBR2:
TGFBR3:
Transducers/SMAD
Ligand inhibitors
Coreceptors
Other


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