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Bone morphogenetic protein 8A

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
BMP8A
Identifiers
Aliases BMP8A , entrez:353500, bone morphogenetic protein 8a, OP-2
External IDsMGI: 104515; HomoloGene: 135983; GeneCards: BMP8A; OMA:BMP8A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human) [1]
Band 1p34.3Start39,491,636 bp [1]
End39,529,869 bp [1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr. Chromosome 4 (mouse)[2]
Band 4 D2.2|4 57.42 cMStart123,206,438 bp [2]
End123,237,045 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • periodontal fiber

  • tibia

  • C1 segment

  • left ovary

  • right ovary

  • islet of Langerhans

  • smooth muscle tissue

  • tibial nerve
  • decidua

  • gastrula

  • intestinal villus

  • calvaria

  • hair follicle

  • molar

  • jejunum

  • embryo

  • Ileal epithelium

  • body of femur
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

353500

12163

Ensembl

ENSG00000183682

ENSMUSG00000032726

UniProt

Q7Z5Y6

P34821

RefSeq (mRNA)

NM_181809

NM_001256019
NM_007558

RefSeq (protein)

NP_861525

NP_001242948
NP_031584

Location (UCSC)Chr 1: 39.49 – 39.53 Mb Chr 4: 123.21 – 123.24 Mb
PubMed search[3] [4]
Wikidata

Bone morphogenetic protein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene.[5]

BMP8A is a polypeptide member of the TGFβ superfamily of proteins. It, like other bone morphogenetic proteins (BMPs), is involved in the development of bone and cartilage. BMP8A may be involved in epithelial osteogenesis. It also plays a role in bone homeostasis. It is a disulfide-linked homodimer.

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183682Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032726Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: bone morphogenetic protein 8a".
[edit ]

Further reading

[edit ]
TGF beta superfamily of ligands
Ligand of ACVR or TGFBR
Ligand of BMPR
TGF beta receptors
(Activin, BMP, family)
TGFBR1:
TGFBR2:
TGFBR3:
Transducers/SMAD
Ligand inhibitors
Coreceptors
Other
Type I
ALK1 (ACVRL1)
ALK2 (ACVR1A)
ALK3 (BMPR1A)
ALK4 (ACVR1B)
ALK5 (TGFβR1)
ALK6 (BMPR1B)
ALK7 (ACVR1C)
Type II
TGFβR2
BMPR2
ACVR2A (ACVR2)
ACVR2B
AMHR2 (AMHR)
Type III
TGFβR3 (β-glycan)
Unsorted


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