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Monoamine-depleting agent

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Drug class
Reserpine, a monoamine-depleting agent

Monoamine-depleting agents are a group of drugs which reversibly deplete one or more of the monoamine neurotransmitters – serotonin, dopamine, and norepinephrine.[1] [2] One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2.[2] [3] Examples of monoamine-depleting agents include deutetrabenazine, oxypertine, reserpine, tetrabenazine, and valbenazine.[1] [2] [3] Tetrabenazine selectively depletes dopamine at low doses and is used as an animal model of amotivation.[4] [5]

Monoamine synthesis inhibitors, such as the tryptophan hydroxylase inhibitor and serotonin synthesis inhibitor para-chlorophenylalanine (PCPA or fenclonine), also act as monoamine-depleting agents, as do various other agents, for instance monoaminergic neurotoxins.[6]

See also

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References

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  1. ^ a b Carlsson A (1975). "Monoamine-depleting drugs". Pharmacol Ther B. 1 (3): 393–400. doi:10.1016/0306-039x(75)90045-8. PMID 772709.
  2. ^ a b c Vijayakumar D, Jankovic J (May 2016). "Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia". Drugs. 76 (7): 779–87. doi:10.1007/s40265-016-0568-1. PMID 27091214. S2CID 13570794.
  3. ^ a b Guay DR (August 2010). "Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders". Am J Geriatr Pharmacother. 8 (4): 331–73. doi:10.1016/j.amjopharm.201008006. PMID 20869622.
  4. ^ Callaghan CK, Rouine J, O'Mara SM (2018). "Potential roles for opioid receptors in motivation and major depressive disorder". Prog Brain Res. 239: 89–119. doi:10.1016/bs.pbr.201807009. PMID 30314570.
  5. ^ Salamone JD, Correa M, Ferrigno S, Yang JH, Rotolo RA, Presby RE (October 2018). "The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation". Pharmacol Rev. 70 (4): 747–762. doi:10.1124/pr.117.015107. PMC 6169368 . PMID 30209181.
  6. ^ Carlsson A (1975). "Monoamine-depleting drugs". Pharmacol Ther B. 1 (3): 393–400. doi:10.1016/0306-039x(75)90045-8. PMID 772709.


DAT Tooltip Dopamine transporter
(DRIs Tooltip Dopamine reuptake inhibitors)
NET Tooltip Norepinephrine transporter
(NRIs Tooltip Norepinephrine reuptake inhibitors)
SERT Tooltip Serotonin transporter
(SRIs Tooltip Serotonin reuptake inhibitors)
VMATs Tooltip Vesicular monoamine transporters
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