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Hypidone

From Wikipedia, the free encyclopedia
Investigational antidepressant drug
Pharmaceutical compound
Hypidone
Clinical data
Other namesYL-0919; YL0919
Identifiers
  • 1-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]pyridin-2-one
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C18H22N2O2
Molar mass 298.386 g·mol−1
3D model (JSmol)
  • C1CN(CCC1(CN2C=CC=CC2=O)O)CC3=CC=CC=C3
  • InChI=1S/C18H22N2O2/c21-17-8-4-5-11-20(17)15-18(22)9-12-19(13-10-18)14-16-6-2-1-3-7-16/h1-8,11,22H,9-10,12-15H2
  • Key:BGMVOROUOUVVRV-UHFFFAOYSA-N

Hypidone (developmental code name YL-0919) is an investigational serotonergic antidepressant which is under development for the treatment of major depressive disorder.[1] [2] [3] [4] [5] It acts as a serotonin reuptake inhibitor, 5-HT1A receptor partial agonist, and 5-HT6 receptor full agonist.[1] [5] It is used as the hydrochloride salt.[2] [5] As of January 2021, hypidone is in phase 2 clinical trials for major depressive disorder.[1]

See also

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References

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  1. ^ a b c "Hypidone hydrochloride - Shanghai Synergy Pharmaceutical Sciences - AdisInsight". adisinsight.springer.com. Retrieved 2021年10月09日.
  2. ^ a b Zhang LM, Wang XY, Zhao N, Wang YL, Hu XX, Ran YH, Liu YQ, Zhang YZ, Yang RF, Li YF (May 2017). "Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT1A agonist". British Journal of Pharmacology. 174 (9): 769–780. doi:10.1111/bph.13675. PMC 5386994 . PMID 27882537.
  3. ^ Chen XF, Jin ZL, Gong Y, Zhao N, Wang XY, Ran YH, Zhang YZ, Zhang LM, Li YF (August 2018). "5-HT6 receptor agonist and memory-enhancing properties of hypidone hydrochloride (YL-0), a novel 5-HT1A receptor partial agonist and SSRI". Neuropharmacology. 138: 1–9. doi:10.1016/j.neuropharm.2018年05月02日7. PMID 29805118. S2CID 44125.
  4. ^ Yin YY, Tian CY, Fang XX, Shang C, Zhang LM, Xu Q, Li YF (2020). "The Faster-Onset Antidepressant Effects of Hypidone Hydrochloride (YL-0919) in Monkeys Subjected to Chronic Unpredictable Stress". Front Pharmacol. 11: 586879. doi:10.3389/fphar.2020.586879 . PMC 7725870 . PMID 33324217.
  5. ^ a b c Liu WG, Zhang LM, Yao JQ, Yin YY, Zhang XY, Li YF, Cao JB (2021). "Anti-PTSD Effects of Hypidone Hydrochloride (YL-0919): A Novel Combined Selective 5-HT Reuptake Inhibitor/5-HT1A Receptor Partial Agonist/5-HT6 Receptor Full Agonist". Front Pharmacol. 12: 625547. doi:10.3389/fphar.2021.625547 . PMC 7902863 . PMID 33643051.
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DAT Tooltip Dopamine transporter
(DRIs Tooltip Dopamine reuptake inhibitors)
NET Tooltip Norepinephrine transporter
(NRIs Tooltip Norepinephrine reuptake inhibitors)
SERT Tooltip Serotonin transporter
(SRIs Tooltip Serotonin reuptake inhibitors)
VMATs Tooltip Vesicular monoamine transporters
Others
5-HT1
5-HT1A
5-HT1B
5-HT1D
5-HT1E
5-HT1F
5-HT2
5-HT2A
5-HT2B
5-HT2C
5-HT3 7
5-HT3
5-HT4
5-HT5A
5-HT6
5-HT7


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