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Methylprednisolone acetate

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Chemical compound
Pharmaceutical compound
Methylprednisolone acetate
Clinical data
Trade names Depo-Medrol, Depo-Medrate, Depo-Medrone, others
Other namesDepot methylprednisolone acetate; Methylprednisolone 21-acetate; 6α-Methylprednisolone 21-acetate; NSC-48985
Routes of
administration
Intramuscular injection
Drug class Corticosteroid; Glucocorticoid
Legal status
Legal status
Identifiers
  • [2-[(6S,10R,11S,13S,17R)-11,17-Dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.157 Edit this at Wikidata
Chemical and physical data
Formula C24H32O6
Molar mass 416.514 g·mol−1
3D model (JSmol)
  • C[C@H]1CC2C3CC[C@@]([C@]3(C[C@@H](C2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)C)O
  • InChI=1S/C24H32O6/c1-13-9-16-17-6-8-24(29,20(28)12-30-14(2)25)23(17,4)11-19(27)21(16)22(3)7-5-15(26)10-18(13)22/h5,7,10,13,16-17,19,21,27,29H,6,8-9,11-12H2,1-4H3/t13-,16?,17?,19-,21?,22-,23-,24-/m0/s1
  • Key:PLBHSZGDDKCEHR-UFBGDBPHSA-N

Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.[1] [2] [3] [4] [5] [6] [7] It has been formulated as an aqueous suspension for intramuscular, intra-articular, soft tissue, and intralesional injection alone and in combination with lidocaine, a local anesthetic.[1] [4] [5] Methylprednisolone acetate was previously suspended with polyethylene glycol but is no longer formulated with this excipient due to concerns about possible toxicity.[6] [8] Depo methylprednisolone acetate is a depot injection and is absorbed slowly with a duration of weeks to months with a single intramuscular injection.[5]

See also

[edit ]

References

[edit ]
  1. ^ a b "Depo-Medrol- methylprednisolone acetate injection, suspension". DailyMed. 18 January 2019. Retrieved 19 February 2020.
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3.
  3. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1.
  4. ^ a b Muller NF, Dessing RP, eds. (19 June 1998). European Drug Index: European Drug Registrations (Fourth ed.). CRC Press. pp. 337–. ISBN 978-3-7692-2114-5.
  5. ^ a b c Plumb DC (21 February 2018). Plumb's Veterinary Drug Handbook: Pocket. John Wiley & Sons. pp. 1088–1091. ISBN 978-1-119-34649-4.
  6. ^ a b Lennard TA, Vivian DG, Walkowski, Singla AK (11 June 2011). Pain Procedures in Clinical Practice E-Book. Elsevier Health Sciences. pp. 8–. ISBN 978-1-4377-3774-5.
  7. ^ Scott DW, Miller Jr WH (1 December 2010). Equine Dermatology - E-Book. Elsevier Health Sciences. pp. 122–. ISBN 978-1-4377-0921-6.
  8. ^ Canale ST, Beaty JH (29 October 2012). Campbell's Operative Orthopaedics E-Book. Elsevier Health Sciences. pp. 1906–. ISBN 978-0-323-08718-6.
Glucocorticoids
Natural
Synthetic
Antiglucocorticoids
Synthesis modifiers
GR Tooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMs Tooltip Selective glucocorticoid receptor agonists)
Antagonists
Others


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