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Locicortolone

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Chemical compound
Pharmaceutical compound
Locicortolone
Clinical data
Other namesLocicortone; RU-24476; 9α,11β-Dichloro-21-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
Drug class Corticosteroid; Glucocorticoid
Identifiers
  • (8S,9R,10S,11S,13S,14S,16R,17S)-9,11-Dichloro-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C22H28Cl2O3
Molar mass 411.36 g·mol−1
3D model (JSmol)
  • C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)Cl)Cl)C
  • InChI=1S/C22H28Cl2O3/c1-12-8-16-15-5-4-13-9-14(26)6-7-21(13,3)22(15,24)18(23)10-20(16,2)19(12)17(27)11-25/h6-7,9,12,15-16,18-19,25H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
  • Key:FKRMBGXNTOTQDI-IIEHVVJPSA-N

Locicortolone (developmental code name RU-24476), or locicortone, is a synthetic glucocorticoid corticosteroid which was never marketed.[1] [2]

References

[edit ]
  1. ^ Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 3795. ISBN 978-3-527-30247-5.
  2. ^ "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). World Health Organization. 2013. Archived from the original (PDF) on 22 October 2014.


GR Tooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMs Tooltip Selective glucocorticoid receptor agonists)
Antagonists
Others


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