C. albicans SSY1/C2_04060C Summary

Last curated 2025年09月02日
See the Literature Guide for most recent publications.

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Summary
Locus History Literature Gene Ontology Phenotype Homologs Protein
SSY1 BASIC INFORMATION [ View References ]
Standard Name SSY11
Systematic Name, Reference Strain C2_04060C_A (C. albicans SC5314)
Assembly 19/21 Identifier orf19.814
Alias CSY12
orf19.8434, IPF5802.23 , IPF29641.13 , IPF29694.13 , Contig4-2714_00074 , orf6.67055 , SSY1.56 , CA42153 , orf19.814.3, CaO19.8147 , orf19.814, C2_04060C_B, C2_04060C
Feature Type ORF, Verified
Description Amino acid sensor; required for wild-type hyphal growth on solid serum or Lees media, not under all conditions; 12 predicted membrane spanning regions; Hap43-repressed; Spider biofilm induced (1, 2, 8, 9)
Literature
Allele Name C2_04060C_B
Allelic Variation Synonymous variation between alleles
CUG Codons C2_04060C_A: 7
C2_04060C_B: 7
Systematic Names Used in Other Strains CAWG_04164 (C. albicans WO-1)
Orthologous genes in Candida species C. parapsilosis CDC317 Ortholog(s) : CPAR2_209340
C. dubliniensis CD36 Ortholog(s) : Cd36_18710
C. auris B8441 Ortholog(s) : B9J08_003623
C. glabrata CBS138 Ortholog(s) : CAGL0E01089g
View ortholog cluster : 19 genes among 19 Candida-related species/strains
Ortholog(s) in non-CGD species S. cerevisiae (SSY1)
Best hit(s) in non-CGD species A. nidulans (AN5678) ; N. crassa (NCU07129) ; S. pombe (SPCC777.04)
JBrowse

JBrowse for feature C2_04060C_A

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GO Annotations View all SSY1 GO evidence and references

Molecular Function
Manually curated * amino acid binding (ISS with S. cerevisiae: SSY1, IMP)
* peptidoglycan binding (IMP)

Biological Process
Manually curated * adaptation to pheromone regulating conjugation with mutual genetic exchange (IMP)
* amino acid transmembrane transport (IMP)
* cellular response to biotic stimulus (IMP)
* cellular response to neutral pH (IMP)
* cellular response to nutrient (IMP)
* cellular response to nutrient levels (IMP)
* detection of nutrient (IMP)
* filamentous growth (IMP)
* filamentous growth of a population of unicellular organisms in response to biotic stimulus (IMP)
* filamentous growth of a population of unicellular organisms in response to neutral pH (IMP)
* response to amino acid (IMP)

Cellular Component
Manually curated * membrane (ISS)
Computational * membrane (IEA with EBI: Amino acid permease/ SLC12A domain)
Mutant Phenotype View all SSY1 Phenotype details and references
Classical genetics
heterozygous null * small molecule transport: normal
* viable

homozygous null * OPT1|OPT2|OPT3 accumulation: absent
* hyphal growth: decreased
* hyphal growth: normal
* Stp2p modification: absent
* resistance to L-glutamic acid gamma-hydrazide: increased
* small molecule transport: abnormal
* utilization of carbon source: decreased
* viable
* virulence: decreased

Large-scale survey
heterozygous null * viable

homozygous null * viable

null * viable

Sequence Information Ca22chr2A_C_albicans_SC5314:857303 to 854661 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to2643857,303to854,6612016年01月21日2014年06月24日

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays
Sequence Information Ca22chr2A_C_albicans_SC5314:857303 to 854661 | JBrowse
Note: this feature is encoded on the Crick strand.
Allele Location
Allele C2_04060C_B 		Ca22chr2B_C_albicans_SC5314:857338 to 854696 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to2643857,338to854,6962016年01月21日2014年06月24日

Allele Location
Allele C2_04060C_B Ca22chr2B_C_albicans_SC5314:857338 to 854696 | JBrowse
Note: this feature is encoded on the Crick strand.
External Links CGOB | Entrez Gene (1, 2) | Fungal Orthologs | FungiDB | GenBank (1, 2, 3, 4, 5) | Non-periodic Expression | Pedant | PhylomeDB | TrEMBL
Primary CGDID CAL0000180720
ADDITIONAL INFORMATION for SSY1
Gene/Sequence Resources
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SSY1]
1) Nobile CJ, et al. (2003) Genetic control of chlamydospore formation in Candida albicans. Microbiology 149(Pt 12):3629-37
CGD Papers Entry Pubmed Entry Reference LINKOUT
2) Brega E, et al. (2004) Candida albicans Csy1p is a nutrient sensor important for activation of amino acid uptake and hyphal morphogenesis. Eukaryot Cell 3(1):135-43
CGD Papers Entry Pubmed Entry Reference LINKOUT
3) CandidaDB
CGD Papers Entry
4) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19.
CGD Papers Entry
5) CGD (2005) CGD comparison of orf6 and orf19 predicted protein products.
CGD Papers Entry
6) Braun BR, et al. (2005) A human-curated annotation of the Candida albicans genome. PLoS Genet 1(1):36-57
CGD Papers Entry Pubmed Entry
7) Maglott D, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 35(Database issue):D26-31
CGD Papers Entry Pubmed Entry Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT
8) Singh RP, et al. (2011) Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans. J Biol Chem 286(28):25154-70
CGD Papers Entry Pubmed Entry Reference LINKOUT Data
9) Nobile CJ, et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148(1-2):126-38
CGD Papers Entry Pubmed Entry Reference LINKOUT Data

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