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4. YAMAMOTO Hiroshi

Researcher Name

YAMAMOTO Hiroshi

Div (Section) name/title

Health and Environmental Risk Division/Director

Research Subject

Research on ecotoxicity and ecological risk of micropollutants, mixtures, and ambient waters

Degree(s)

Ph.D.

Professional Qualification(s)

Chemistry,Biology,Civil Engineering

Environmental Speciality Field

micropollutants,ecotoxicity,environmental fate

Keyword(s)

bioassay,bioaccumulation,partitioning and persistence,risk assessment,toxicity reduction evaluation,toxicity identification evaluation,whole effluent toxicity

Brief Description of Research

I have been working on environmental fate and ecological risk of micropollutants. More recently, focus has been mainly on ecotoxicity of pharmaceuticals and personal care products and evaluation and control of mixtures, factory effluents and ambient waters using bioassay.

Career

Mar 1995, BS from Department of Sanitary Engineering, Kyoto University
Mar 1997, MS from Department of Global Environmental Engineering, Kyoto University
May 2002, Ph.D. from Graduate School of Engineering, The University of Texas at Austin
Jun 2002, NIES postdoctoral fellow, Endocrine disruptors and dioxin research project, NIES
Apr 2004, Instructor, Faculty of Integrated Arts and Sciences, Tokushima Univeristy
Apr 2007, Associate Professor, Faculty of Integrated Arts and Sciences, Tokushima Univeristy
Apr 2009, Associate Professor, Institute of Socio, Arts, and Sciences, Tokushima Univeristy
Apr 2016, Section Head, Ecotoxicity Research Section, Center for Environmental Health and Risk Research, NIES
Apr 2018, Deputy Director, Center for Environmental Health and Risk Research, NIES
Apr 2021, Deputy Director, Environmental Health and Risk Division, NIES
Visiting Professor, Natural Dept. of Natural Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo

Membership of Academic Society

Society of Environmental Toxicology and Chemistry,Japan Society on Water Environment (JSWE),Japan Society for Environmental Chemistry,The Japanese Society of Environmental Toxicology,American Chemical Society,The Society for Risk Analysis Japan

Research Subject

• Fiscal Year: 2025
  • 27191 : Comprehensive Environmental Risk Research Program
  • 27196 : Health and environmental risk research field
  • 27217 : Research project on the ecological impact and factor analysis considering vulnerability
  • 27220 : Research on the development of comprehensive indexes of health risk and ecological risk
  • 27381 : A fundamental study for evaluating health impact of environmental factors
  • 27391 : Basic research on ecotoxicity from the viewpoint of molecular to organism or population level
  • 27392 : Assessment of effects on marine organisms exposed to microplastics via water and sediment
  • 27419 : Developing a water quality health assessment system for offshore exploitation sites
  • 27459 : Establishment of evaluation methods to understand the actual condition of degradation and fragmentation of plastic garbage on the seafloor by physical and biological processes
  • 27512 : The study for establishing a new fish acute toxicity test concerning animal welfare
  • 27513 : Fundamental study for standardization of ecotoxicity
  • 27514 : Development of novel bioassay technique
• Fiscal Year: 2024
  • 26803 : Comprehensive Environmental Risk Research Program
  • 26809 : Health and environmental risk research field
  • 26831 : Research project on the ecological impact and factor analysis considering vulnerability
  • 26835 : Research on the development of comprehensive indexes of health risk and ecological risk
  • 26945 : Developing a water quality health assessment system for offshore exploitation sites
  • 26947 : A fundamental study for evaluating health impact of environmental factors
  • 26992 : Establishment of evaluation methods to understand the actual condition of degradation and fragmentation of plastic garbage on the seafloor by physical and biological processes
  • 27002 : Development of ecological risk assessment methods for multiple chemicals based on the similarity of activity/structure and exposure profile
  • 27037 : Basic research on ecotoxicity from the viewpoint of molecular to organism or population level
  • 27038 : Assessment of effects on marine organisms exposed to microplastics via water and sediment
  • 27041 : FY2024 Contract work on the development and validation of new ecotoxicity test methods in OECD and the support for GLP inspection activities
  • 27077 : The study for establishing a new fish acute toxicity test concerning animal welfare
  • 27078 : Fundamental study for standardization of ecotoxicity
  • 27079 : Development of novel bioassay technique
  • 27131 : FY2024 Contract work on test method development for endocrine disrupting chemicals
  • 27132 : Study on risk assessment of chemicals using effect directed analysis in FY2024
  • 27147 : Implementation of environmental risk assessment in CSCL and investigation on the advanced procedure
  • 27148 : Implementation of initial risk assessment of environmental chemicals
  • 27151 : Study on a prediction method of ecotoxicity to aquatic life
  • 27360 : Contract study on the ecological risk assessment of multiple chemicals in FY2024
  • 27361 : FY2024 Contract research work on the development of new assessment method for ecological risk of pesticides
  • 27411 : Profile analysis of ecotoxicity of bioplastic eluates using marine organisms
  • 27412 : Research on utilization of bioassays for management of various water environments
• Fiscal Year: 2023
  • 26403 : Comprehensive Environmental Risk Research Program
  • 26421 : Research project on the ecological impact and factor analysis considering vulnerability
  • 26424 : Research on the development of comprehensive indexes of health risk and ecological risk
  • 26443 : Health and environmental risk research field
  • 26538 : Establishment of evaluation methods to understand the actual condition of degradation and fragmentation of plastic garbage on the seafloor by physical and biological processes
  • 26715 : Basic research on ecotoxicity from the viewpoint of molecular to organism or population level
  • 26716 : Development of ecological risk assessment methods for multiple chemicals based on the similarity of activity/structure and exposure profile
  • 26717 : Profile analysis of ecotoxicity of bioplastic eluates using marine organisms
  • 26718 : Study on development of framework for environmental risk assessment of new pharmaceuticals by integrated approaches to testing and assessment (IATA)
  • 26719 : Research on utilization of bioassays for management of various water environments
  • 26720 : FY2023 Contract work on the development and validation of new ecotoxicity test methods in OECD and the support for GLP inspection activities
  • 26725 : Developing a water quality health assessment system for offshore exploitation sites
  • 26755 : FY2023 Contract work on test method development for endocrine disrupting chemicals
  • 26756 : FY2023 Contract research work on the development of new assessment method for ecological risk of pesticides
  • 26757 : Study on risk assessment of chemicals using effect directed analysis in FY2023
  • 26768 : Contract study on the ecotoxicity testing for the development of assessment of chemical mixtures in FY2022
  • 26769 : Assessment of effects on marine organisms exposed to microplastics via water and sediment
  • 26787 : Implementation of environmental risk assessment in CSCL and investigation on the advanced procedure
  • 26788 : Implementation of initial risk assessment of environmental chemicals
  • 26791 : Study on a prediction method of ecotoxicity to aquatic life
  • 26792 : Investigation on the water environmental quality standard for conservation of aquatic organisms
  • 26793 : The study for establishing a new fish acute toxicity test concerning animal welfare
  • 26794 : Fundamental study for standardization of ecotoxicity
  • 26795 : Development of novel bioassay technique
• Fiscal Year: 2022
  • 25972 : Comprehensive Environmental Risk Research Program
  • 25974 : Research project on the ecological impact and factor analysis considering vulnerability
  • 25977 : Research on the development of comprehensive indexes of health risk and ecological risk
  • 26008 : Health and environmental risk research field
  • 26283 : Implementation of environmental risk assessment in CSCL and investigation on the advanced procedure
  • 26284 : Implementation of initial risk assessment of environmental chemicals
  • 26288 : Study on a prediction method of ecotoxicity
  • 26297 : Basic research on ecotoxicity from the viewpoint of molecular to organism or population level
  • 26298 : FY2021-2022 Tier 2 Testing for endocrine disrupting chemical (17β-estradiol)
  • 26337 : Development of ecological risk assessment methods for multiple chemicals based on the similarity of activity/structure and exposure profile
  • 26338 : FY2022 Contract work on test method development for endocrine disrupting chemicals
  • 26339 : FY2022 Contract work on the development and validation of new ecotoxicity test methods in OECD and the support for GLP inspection activities
  • 26340 : Profile analysis of ecotoxicity of bioplastic eluates using marine organisms
  • 26357 : Study on development of framework for environmental risk assessment of new pharmaceuticals by integrated approaches to testing and assessment (IATA)
  • 26396 : Study on risk assessment of chemicals using effect directed analysis in FY2022
  • 26397 : Contract study on the ecotoxicity testing for the development of assessment of chemical mixtures in FY2022
  • 26398 : FY2022 Contract research work on the development of new assessment method for ecological risk of pesticides
  • 26399 : Research on utilization of bioassays for management of various water environments
• Fiscal Year: 2021
  • 25501 : Comprehensive environmental risk research program
  • 25518 : Study on ecological impact and factor analysis considering vulnerability
  • 25521 : Research on the development of comprehensive indexes of health risk and ecological risk
  • 25540 : Health and environmental risk research field
  • 25752 : Basic research on ecotoxicity from the viewpoint of molecular to organism or population level
  • 25876 : Developing risk assessment methods for chemicals in sediment that consider exposure routes and bioavailability to benthic organisms
  • 25882 : Development of the prediction system for environmental effects by new drugs based on the evaluation results of environmental toxicity by existing drugs
  • 25883 : Comparison of various bioassay for testing water quality of ambient water samples
  • 25892 : FY2021 Contract work on test method development for endocrine disrupting chemicals
  • 25895 : FY2021 Contract work on the development and validation of new ecotoxicity test methods in OECD
  • 25897 : FY2021 Contract research work on the development of new assessment method for ecological risk of pesticides
  • 25927 : Study on practical assessment technique for marine environment during seafloor mineral mining
  • 25938 : Study on risk assessment of chemicals using effect directed analysis in FY2021
  • 25942 : Study on the ecotoxicity testing for the development of assessment of chemical mixtures in FY2021
  • 25943 : FY2021-2022 Tier 2 Testing for endocrine disrupting chemical (17β-estradiol)
  • 25949 : Implementation of environmental risk assessment in CSCL and investigation on the advanced procedure in FY2021
  • 25950 : Implementation of initial risk assessment of environmental chemicals
  • 25961 : Study on a prediction method of ecotoxicity
• Fiscal Year: 2020
  • 25099 : Research Program on Health and Environmental Safety
  • 25124 : Risk Assessment Science Collaboration Office
  • 25144 : Project to Build a System Evaluating Ecological Effect Comprehensively and Effectively
  • 25148 : Research Project on the Scientific and Social Framework of Risk Assessment and Management
  • 25359 : Study on practical assessment technique for marine environment during seafloor mineral mining
  • 25362 : Comparison of various bioassay for testing water quality of ambient water samples
  • 25363 : Development of the prediction system for environmental effects by new drugs based on the evaluation results of environmental toxicity by existing drugs
  • 25364 : FY2019-2020 Tier 2 Testing for endocrine disrupting chemical (17α-ethynylestradiol)
  • 25365 : Upgrade of Ecotoxicity Testing and Development of Novel System to Evaluate Ecotoxicological Effects of Chemicals
  • 25366 : Development of short-term chronic toxicity tests using marine and estuarine species
  • 25379 : Developing risk assessment methods for chemicals in sediment that consider exposure routes and bioavailability to benthic organisms
  • 25401 : Study on revision of OECD fish, acute toxicity testing
  • 25407 : The development of new ecological risk assessment method for agricultural chemicals
  • 25423 : Implementation of initial risk assessment of environmental chemicals
  • 25424 : Implementation of risk assessment in CSCL and investigation on the advanced procedure in FY2020
• Fiscal Year: 2019
  • 24696 : Research Program on Health and Environmental Safety
  • 24724 : Project to Build a System Evaluating Ecological Effect Comprehensively and Effectively
  • 24728 : Research Project on the Scientific and Social Framework of Risk Assessment and Management
  • 24756 : Risk Assessment Science Collaboration Office
  • 24898 : FY2019 study on prediction method of ecotoxicity
  • 24900 : Implementation of risk assessment in CSCL and investigation on the advanced procedure in FY2019
  • 24901 : Implementation of initial risk assessment of environmental chemicals in FY2019
  • 24930 : The study of impacts of chelating agents on algal species
  • 25020 : Upgrade of Ecotoxicity Testing and Development of Novel System to Evaluate Ecotoxicological Effects of Chemicals
  • 25021 : Development of short-term chronic toxicity tests using marine and estuarine species
  • 25022 : FY2019 Validation research on the amendment of the OECD fish acute toxicity test guideline
  • 25042 : Developing risk assessment methods for chemicals in sediment that consider exposure routes and bioavailability to benthic organisms
  • 25050 : Development of the prediction system for environmental effects by new drugs based on the evaluation results of environmental toxicity by existing drugs
  • 25051 : Comparison of various bioassay for testing water quality of ambient water samples
  • 25052 : Study on practical assessment technique for marine environment during seafloor mineral mining
  • 25089 : FY2019 Investigation on Toxicity Testing and Evaluation Methods of Difficult Chemicals
  • 25091 : FY2019 Study on the Development of Assessment Procedure for the Mixture Effects of Chemicals Using Ecotoxicity Testing
  • 25092 : FY2019 Contract research work on risk assessment of chemicals using the effect-directed analysis
  • 25093 : FY2019 Development of Testing Methods Regarding Endocrine Disrupting Effects of Chemicals
  • 25094 : FY2019-2020 Tier 2 Testing for endocrine disrupting chemical (17α-ethynylestradiol)
  • 25095 : FY2019 Research on the development of novel methods for the assessment of ecological risk of pesticides in aquatic environment
• Fiscal Year: 2018
  • 24307 : Project to build a system evaluating ecological effect comprehensively and effectively
  • 24339 : Risk Assessment Science Collaboration Office
  • 24355 : Research program on health and environmental safety
  • 24532 : Upgrade of ecotoxicity testing and development of novel system to evaluate ecotoxicological effects of chemicals
  • 24533 : Case study on biological risk in aquatic environment using WET method
  • 24534 : FY2017-2018 Tier 2 Biological Tests Regarding Chemicals with Endocrine Disrupting Effects
  • 24535 : FY2018 Development of Testing Methods Regarding Endocrine Disrupting Effects of Chemicals
  • 24536 : FY2018 Study on the Development of Assessment Procedure for the Mixture Effects of Chemicals Using Ecotoxicity Testing
  • 24537 : Investigation on water environment management method using biological responses in FY 2018
  • 24538 : Development of short-term chronic toxicity tests using marine and estuarine species
  • 24552 : FY2018 Study on QSAR Technique Regarding Ecotoxicity
  • 24581 : Implementation of risk assessment in CSCL and investigation on the advanced procedure in FY2018
  • 24582 : Implementation of initial risk assessment of environmental chemicals in FY2018
• Fiscal Year: 2017
  • 23821 : Project to build a system evaluating ecological effect comprehensively and effectively
  • 23847 : Research program on health and environmental safety
  • 23860 : Risk Assessment Science Collaboration Office
  • 24067 : Upgrade of ecotoxicity testing and development of novel system to evaluate ecotoxicological effects of chemicals
  • 24101 : Case study on biological risk in aquatic environment using WET method
  • 24183 : FY2017 Study on QSAR Technique Regarding Ecotoxicity
  • 24184 : FY2017 Development of Testing Methods Regarding Endocrine Disrupting Effects of Chemicals
  • 24185 : FY2017-2018 Tier 2 Biological Tests Regarding Chemicals with Endocrine Disrupting Effects
  • 24186 : FY2017 Investigation on Toxcity Testing of Difficult Test Chemicals
• Fiscal Year: 2016
  • 23414 : Research program on health and environmental safety
  • 23418 : Project to build a system evaluating ecological effect comprehensively and effectively
  • 23516 : Comparison of acute and chrnonic toxicity of water samples collected in selected class A rivers in Japan and ecotoxicity of sediment samples
  • 23572 : Upgrade of ecotoxicity testing and development of novel system to evaluate ecotoxicological effects of chemicals
  • 23755 : Implementation of Risk assessment in CSCL and investigation on the advanced procedure in 2016FY
  • 23758 : Investigation on the water environmental quality standard for conservation of aquatic organisms in FY 2016
  • 23772 : Study on ecotoxicity QSAR methods (FY2016)
  • 23812 : Study on toxicity tests for difficult test chemicals (FY2016)

Research Result (Publication)

• all
• Original Paper
• Review
• Book
• Other Publications

• Original Paper
  Comparative analysis of fish embryo acute toxicity (FET) test, fish cell line acute toxicity test and acute fish toxicity test: Evaluating the applicability domain of the FET test

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Title : , Environmetal Toxicology and Chemistry (2026)
• Original Paper
  Workshop report: scoping for the development of a proposal for an OECD guidance document on fish vitellogenin assessment

  Presenter : Burden N., Aubee C., Augusiak J., Baccaro M., Boehler S., Brion F., Brown R.J., Coady K.K. , Dang Z., Eilebrecht E., Fagundes T., Fisher T., Fryer M., Gao Z., Goodband T., Hecker M. , Holbech H., Hoeger S., Jacobs M., Katsiadaki I., Kearney P., Koerner O., Krzykwa J. , Marini J., Maunder R., Maynard S.K. , Mikkelsen F., Mingo V. , Panter G.H., Pearson A., Pellizzato F., Salinas E.R., Schneider S.Z. , Snow A., Sewell F., Stahlschmidt P. , Thorpe K., Villeneuve D.L., Weltje L. , Wheeler J.R., Yamamoto H.
  Title : , Integrated Environmental Assessment and Management, 22(1):11-20 (2026)
• Original Paper
  Ecotoxicity assessment of phthalic acid di-alkyl ester mixtures toward aquatic organisms based on results from a series of subchronic toxicity tests

  Presenter : Oda Y., Kawano M., Watanabe H., Yamagishi T., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry (2025)
• Original Paper
  Polyethylene microbead distribution in sediment toxicity test system with estuarine amphipod Grandidierella japonica

  Presenter : Hiki K., Namba N,, Watanabe H., Yamagishi T., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry, 44(11):3086-3094 (2025)
• Original Paper
  Determining the appropriateness of timely euthanasia in acute fish toxicity testing using observed clinical signs to predict time of death.

  Presenter : Yamagishi T., Huang R., Ohno K., Yamamoto H.
  Title : , Environmetal Toxicology and Chemistry, 45:391-397 (2025)
• Original Paper
  Identification of ecdysteroids and ecdysteroidogenic genes in dragonflies and damselflies

  Presenter : Okuda G., Ogihara M.H., Moriyama M., Yamagishi T., Yamamoto H., Fukatsu T., Futahashi R.
  Title : , Scientific Report (2025)
• Original Paper
  Relative gene expression analysis of catalase in environmental RNA from Japanese medaka exposed to toxic chemicals

  Presenter : Hiki K., Watanabe H., Yamamoto H.
  Title : , Environmental DNA, 6(2):e532 (2024)
• Original Paper
  Non-chemical stresses do not strongly induce male offspring in Daphnia magna ascertained using the short-term juvenile hormone activity screening assay

  Presenter : Watanabe H., Abe R., Tatarazako N., Yamamoto H.
  Title : , Journal of Applied Toxicology (2024)
• Original Paper
  Prediction of chronic toxicity of pharmaceuticals in Daphnia magna by combining ortholog prediction, pharmacological effects, and quantitative structure-activity relationship

  Presenter : Ninomiya Y., Watanabe H., Yamagishi T., Maruyama-Komoda T., Yamada T., Yamamoto H.
  Title : , Ecotoxicology and Environmental Safety, 282(116737): (2024)
• Original Paper
  Developing a Passive Dosing Method for Acute Aquatic Toxicity Tests of Cationic Surfactant Benzalkoniums (BACs)

  Presenter : Do T., Hiki K., Watanabe H., Yamamoto H., Endo S.
  Title : , Environmental Science & Technology, 58(31):13678-13686 (2024)
• Original Paper
  Freely dissolved concentration profile and Hyalella azteca toxicity of cationic surfactant C12-benzalkonium in spiked-sediment toxicity test

  Presenter : Yoshii S., Hiki K., Watanabe H., Yamamoto H., Endo S.
  Title : , Science of the Total Environment, 866:161226 (2023)
• Original Paper
  Development of a microplate-based novel toxicity bioassay using Chlorophyta and Phaeophyceae macroalgae

  Presenter : Onduka T., Somiya R., Yamagishi T., Hano T., Yamamoto H., Mochida K.
  Title : , Ecotoxicology (2023)
• Original Paper
  Influence of water exchange rates on toxicity and bioaccumulation of hydrophobic organic chemicals in sediment toxicity tests

  Presenter : Hiki K., Fischer F., Nishimori T., Endo S., Watanabe H., Yamamoto H.
  Title : , Environmental Science: Processes & Impacts (2023)
• Original Paper
  Environmental RNA as a Noninvasive Tool for Assessing Toxic Effects in Fish: A Proof-of-concept Study Using Japanese Medaka Exposed to Pyrene

  Presenter : Hiki K., Yamagishi T., Yamamoto H.
  Title : , Environmental Science & Technology, 57(34):12654-12662 (2023)
• Other Publications
  The complete mitochondrial genome of water flea Ceriodaphnia dubia (Crustacea: Cladocera) NIES strain

  Presenter : Hiki K., Oka K., Nakajima N., Watanabe H., Yamamoto H., Yamagishi T.
  Title : , Mitochondrial DNA Part B: Resources, 8(8):831-835 (2023)
• Original Paper
  Concentration and leachability of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its quinone transformation product (6PPD-Q) in road dust collected in Tokyo, Japan

  Presenter : Hiki K., Yamamoto H.
  Title : , Environmental Pollution, 302:119082 (2022)
• Original Paper
  Severity classification of clinical signs and defining the moribund state as an experimental endpoint for acute toxicity testing using Japanese medaka (Oryzias latipes)

  Presenter : Yamagishi T., Kawano M., Watanabe H., Yagi A., Shintaku Y., Ohno K., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry, 41(4):1089-1095 (2022)
• Original Paper
  3D reconstructed brain images reveal the possibility of the ogg1 gene to suppress the irradiation-induced apoptosis in embryoni cbrain in medaka (Oryzias latipes)

  Presenter : YASUDA T., Li D., Kakimoto F., Mitani H., Yamamoto H., Ishikawa-Fujiwara T., Todo T., Oda S.
  Title : , Journal of Radiation Research, 2022:1-12 (2022)
• Review
  Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development

  Presenter : Toyota K., Watanabe H., Hirano M., Abe R., Miyakawa H., Song Y., Sato T., Miyagawa S., Tollefsen K. E., Yamamoto H., Tatarazako N., Iguchi T.
  Title : , Aquatic Toxicology, 243(106058): (2022)
• Original Paper
  Potential differences in chitin synthesis ability cause different sensitivities to diflubenzuron among three strains of Daphnia magna

  Presenter : KATO K., Okamura K., Hiki K., Kintsu H., Nohara K., Yamagishi T., Nakajima N., Watanabe H., Yamamoto H.
  Title : , Aquatic Toxicology, 243(106071): (2022)
• Original Paper
  Comparison of Species Sensitivity Distributions for Sediment-Associated Nonionic Organic Chemicals Through Equilibrium Partitioning Theory and Spiked-Sediment Toxicity Tests with Invertebrates

  Presenter : Hiki K., Iwasaki Y., Watanabe H., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry, 41(412):462-473 (2022)
• Original Paper
  Propidium iodide staining and flow cytometry-based assessment of heavy metal impact on marine phytoplankton

  Presenter : Ota S., Fuchida S., Yamaguchi H., Yamagishi T., Yamamoto H., Koshikawa H., Kawachi M.
  Title : , Cytologia, 87(2):177-187 (2022)
• Original Paper
  Comparing 10‐ and 28‐Day Sediment Toxicity and Bioaccumulation of Fluoranthene in Hyalella azteca Using Passive Sampling Techniques

  Presenter : Nishimori T., Hiki K., Fischer F., Endo S., Yamamoto H., Watanabe H.
  Title : , Environmental Toxicology and Chemistry (2022)
• Original Paper
  Quantitative analyses of misclassification rates in the hazard classification of environmental chemicals: Evaluation of procedures for deriving predicted no-effect concentrations in the Chemical Substance Control Law in Japan

  Presenter : Hayashi T., Furuhama A., Yokomizo H., Yamamoto H.
  Title : , Risk analysis (2022)
• Other Publications
  The Tire-Derived Chemical 6PPD-quinone Is Lethally Toxic to the White-Spotted Char Salvelinus leucomaenis pluvius but Not to Two Other Salmonid Species

  Presenter : Hiki K., Yamamoto H.
  Title : , Environmental Science & Technology Letters, 9(12):1050-1055 (2022)
• Original Paper
  Spatiotemporal distribution of hydrophobic organic contaminants in spiked-sediment toxicity tests: Measuring total and freely dissolved concentrations in pore and overlying water

  Presenter : Hiki K., Fischer F., Nishimori T., Watanabe H., Yamamoto H., Endo S.
  Title : , Environmental Toxicology and Chemistry (2021)
• Original Paper
  Toxicity assessment of typical polycyclic aromatic hydrocarbons to Daphnia magna and Hyalella azteca in water-only and sediment-water exposure systems

  Presenter : Tani K., Watanabe H., Noguchi M., Hiki K., Yamagishi T., Yamamoto H.
  Title : , Science of the Total Environment, 784(147156): (2021)
• Original Paper
  Sources of variation in sediment toxicity of hydrophobic organic chemicals: Meta-analysis of 10-14-day spiked-sediment tests with Hyalella azteca and Chironomus dilutus

  Presenter : Hiki K., Watanabe H., Yamamoto H.
  Title : , Integrated Environmental Assessment and Management, 17(5):1003-1013 (2021)
• Other Publications
  Strategy for development of quantitative structure-activity-activity relationship models for chronic fish toxicity: prediction of early-life stage toxicity to Oryzias latipes from acute Daphnia magna toxicity

  Presenter : Furuhama A., Hayashi T. I., Yamamoto H.
  Title : , Japan Journal of Environmental Toxicology, 24:33-42 (2021)
• Original Paper
  Generating accurate in silico predictions of acute aquatic toxicity for a range of organic chemicals: Towards similarity-based machine learning methods

  Presenter : Gajewicz-Skretna A., Furuhama A., Yamamoto H., Suzuki N.
  Title : , Chemosphere, 280(2021): (2021)
• Review
  International Contributions in Preventing Environmental Pollution by Chemical Substances, Challenges in Assessing the Unknown Toxicity of Chemical Substances

  Presenter : Chemicals Evaluation Office, Yamamoto H.
  Title : , JAPAN Environmental Quarterly, 26:8 (2021)
• Other Publications
  The complete mitochondrial genome of the non-biting midge Chironomus yoshimatsui (Diptera: Chironomidae)

  Presenter : Hiki K., Oka K., Nakajima N., Yamamoto H., Yamagishi T., Sugaya Y.
  Title : , Mitochondrial DNA Part B, 6(10):2995-2996 (2021)
• Original Paper
  Aquatic toxicity (Pre)screening strategy for structurally diverse chemicals: global or local classification tree models?

  Presenter : Gajewicz-Skretna A., Gromelski M., Wyrzykowska E., Furuhama A., Yamamoto H., Suzuki N.
  Title : , Ecotoxicology and Environmental Safety, 208(2021): (2021)
• Other Publications
  Acute Toxicity of a Tire Rubber-Derived Chemical, 6PPD Quinone, to Freshwater Fish and Crustacean Species

  Presenter : Hiki K., Asahina K., KATO K., Yamagishi T., Omagari R., Iwasaki Y., Watanabe H., Yamamoto H.
  Title : , Environmental Science & Technology Letters, 8(9):779-784 (2021)
• Original Paper
  Quantitative structure-activity relationship and a category approach to support algal toxicity assessment of human pharmaceuticals

  Presenter : Yamada T., Kawamura T., Maruyama T., Kurimoto M., Yamamoto H., Katsutani S., Hirose A.
  Title : , Fundamental Toxicological Sciences, 8(7):195-204 (2021)
• Original Paper
  Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

  Presenter : Katsiadaki I., Ellis T., Andersen L., Antczak P., Burden N., Fisher T., Green C., Labram B., Pearson A., Peersen K., Pickford D., Ramsden C., Rønneseth A., Ryder K., SackerD., Stevens C., Watanabe H., Yamamoto H., Sewell F., Hawkins P., Rufli H., Hnady R.D., Maynard S. K., Jacobs M. N.
  Title : , Ecotoxicology and Environmental Safety, 223(2021):112585 (2021)
• Original Paper
  Differential heavy metal sensitivity in seven algal species from the NIES culture collection based on delayed fluorescence assays

  Presenter : Ota S., Yamaguchi H., Vanel F., Fuchida S., Koshikawa H., Yamagishi T., Yamamoto H., Kawachi M.
  Title : , Phycological Research, 68(1):41-49 (2020)
• Original Paper
  Comparative genome analysis of test algal strain NIVA-CHL1 (Raphidocelis subcapitata) maintained in microalgal culture collections worldwide

  Presenter : Yamagishi T., Yamaguchi H., Suzuki S., Yoshikawa M. , Jameson I., Lorenz M., Nobles D.R., Campbell C., Seki M., Kawachi M., Yamamoto H.
  Title : , PLOS ONE, 15(11):e0241889 (2020)
• Original Paper
  Production of genome-edited Daphnia for heavy metal detection by fluorescence

  Presenter : Arao T., Kato Y., Nong Q.D. , Yamamoto H., Watanabe H., Matsuura T., Tatarazako N., Tani K., Okamoto A., Matsumoto T., Watanabe H.
  Title : , Scientific Reports, 10(21490):1-10 (2020)
• Original Paper
  Development of QSAAR and QAAR models for predicting fish early-life stage toxicity with a focus on industrial chemicals

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Title : , SAR and QSAR in Environmental Research , 30(11):825-846 (2019)
• Original Paper
  Whole transcriptome analysis of an estuarine amphipod exposed to highway road dust

  Presenter : Hiki K., Nakajima F., Tobino T., Watanabe H., Yamamoto H.
  Title : , Science of the Total Enviroment, 675:141-150 (2019)
• Book
  Ecotoxicological Bioassay Using Marine Algae for Deep-Sea Mining

  Presenter : Yamagishi T., Ota S., Yamaguchi H., Koshikawa H., Tatarazako, N., Yamamoto H., Kawachi M.
  Title : , Environmental Issues of Deep-Sea Mining: Impacts, Consequences and Policy Perspectives (2019)
• Original Paper
  Development of models to predict fish early-life stage toxicity from acute Daphnia magna toxicity

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Title : , SAR and QSAR in Environmental Research, 29(9):725-742 (2018)
• Other Publications
  Multivariate Analysis of Water Quality and Ecotoxicity to Aquatic Species in the Yoshino River and the Yodo River Basin, Japan

  Presenter : Tamura I., Hayashi T., Nishi-ie S., Enyama M., Mitsuyama M., Tatarazako N., Yamamoto H.
  Title : , 学会誌「EICA」, 23(2,3):75-85 (2018)
• Original Paper
  Contribution of inorganic and organic components to sorption of neutral and ionizable pharmaceuticals by sediment/soil

  Presenter : Yamamoto H., Takemoto K., Tamura I., Shin-oka N., Nakano T., Nishida M., Honda Y., Moriguchi S., Nakamura Y.
  Title : , Environmental Science and Pollution Research, 25(8):7250-7261 (2017)
• Original Paper
  External validation of acute-to-chronic models for estimation of reproductive toxicity to Daphnia magna

  Presenter : Furuhama A., Hayashi T., Yamamoto H., Tatarazako N.
  Title : , SAR and QSAR in Environmental Research, 28(9):765-781 (2017)
• Original Paper
  Contribution of pharmaceuticals and personal care products (PPCPs) to whole toxicity of water samples collected in effluent-dominated urban streams

  Presenter : Tamura I., Yasuda Y., Kagota, K., Nakada N., Kumar V., Kameda Y., Kimura K., Tatarazako N., Yamamoto H.
  Title : , Ecotoxicity and Environmental Safety, 144:338-350 (2017)
• Original Paper
  Ecotoxicity and screening level ecotoxicological risk assessment of five antimicrobial agents: triclosan, triclocarban,resorcinol, phenoxyethanol and p-thymol

  Presenter : Yamamoto H., Tamura I., Kagota K., Yasuda Y., Yoneda S., Morita J., Nakada N., Kameda Y., Kimura K., Tatarazako N., Yamamoto H.
  Title : , Applied Toxicology (2012)
• Original Paper
  The effects of pH on fluoxetine in Japanese medaka(Oryzias latipes): Acute toxicity in fish larvae and bioaccumulation in juvenile fish

  Presenter : Yamamoto H., Nakamura Y., Yamamoto H., Sekizawa J., Kondo T., Hirai N., Tatarazako N.
  Title : , Chemosphere, 70:865-873 (2008)
• Original Paper
  Initial ecological risk assessment of eight selected human pharmaceuticals in Japan

  Presenter : Yamamoto H., Yamamoto H., Nakamura Y., Nakamura Y., Kitani C., Imari T., Sekizawa J., Takao Y., Yamashita N., Hirai N., Oda S., Tatarazako N.
  Title : , Environ.Sci., 14(4):177-193 (2007)
• Original Paper
  Preliminary ecological risk assessment of butylparaben and benzylparaben 1.Removal efficiency in wastewater treatment, Acute/Chronic toxicity for aquatic organisms, and effects on medaka gene expression

  Presenter : Yamamoto H., Koshio M., Yamamoto H., Watanabe M., Hirata Y., Nakamura Y., Nakamura Y., Kitani C., Sekizawa J., Uchida M., Nakamura H., Kagami Y., Hirai N., Tatarazako N.
  Title : , Environ.Sci., 14((Suppl.)):73-87 (2007)
• Bioconcentration factor of relatively low concentrations of chlorophenols in Japanese medaka

  Presenter : , , Yamamoto H.
  Title : , Chemosphere, 61:1299-1304 (2005)
• Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays

  Presenter : , , Kamata R., Yamamoto H.
  Title : , Toxicol.in Vitro, 19:457-469 (2005)

• Comparative analysis of fish embryo acute toxicity (FET) test, fish cell line acute toxicity test and acute fish toxicity test: Evaluating the applicability domain of the FET test

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Title : , Environmetal Toxicology and Chemistry (2026)
• Workshop report: scoping for the development of a proposal for an OECD guidance document on fish vitellogenin assessment

  Presenter : Burden N., Aubee C., Augusiak J., Baccaro M., Boehler S., Brion F., Brown R.J., Coady K.K. , Dang Z., Eilebrecht E., Fagundes T., Fisher T., Fryer M., Gao Z., Goodband T., Hecker M. , Holbech H., Hoeger S., Jacobs M., Katsiadaki I., Kearney P., Koerner O., Krzykwa J. , Marini J., Maunder R., Maynard S.K. , Mikkelsen F., Mingo V. , Panter G.H., Pearson A., Pellizzato F., Salinas E.R., Schneider S.Z. , Snow A., Sewell F., Stahlschmidt P. , Thorpe K., Villeneuve D.L., Weltje L. , Wheeler J.R., Yamamoto H.
  Title : , Integrated Environmental Assessment and Management, 22(1):11-20 (2026)
• Ecotoxicity assessment of phthalic acid di-alkyl ester mixtures toward aquatic organisms based on results from a series of subchronic toxicity tests

  Presenter : Oda Y., Kawano M., Watanabe H., Yamagishi T., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry (2025)
• Polyethylene microbead distribution in sediment toxicity test system with estuarine amphipod Grandidierella japonica

  Presenter : Hiki K., Namba N,, Watanabe H., Yamagishi T., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry, 44(11):3086-3094 (2025)
• Determining the appropriateness of timely euthanasia in acute fish toxicity testing using observed clinical signs to predict time of death.

  Presenter : Yamagishi T., Huang R., Ohno K., Yamamoto H.
  Title : , Environmetal Toxicology and Chemistry, 45:391-397 (2025)
• Identification of ecdysteroids and ecdysteroidogenic genes in dragonflies and damselflies

  Presenter : Okuda G., Ogihara M.H., Moriyama M., Yamagishi T., Yamamoto H., Fukatsu T., Futahashi R.
  Title : , Scientific Report (2025)
• Relative gene expression analysis of catalase in environmental RNA from Japanese medaka exposed to toxic chemicals

  Presenter : Hiki K., Watanabe H., Yamamoto H.
  Title : , Environmental DNA, 6(2):e532 (2024)
• Non-chemical stresses do not strongly induce male offspring in Daphnia magna ascertained using the short-term juvenile hormone activity screening assay

  Presenter : Watanabe H., Abe R., Tatarazako N., Yamamoto H.
  Title : , Journal of Applied Toxicology (2024)
• Prediction of chronic toxicity of pharmaceuticals in Daphnia magna by combining ortholog prediction, pharmacological effects, and quantitative structure-activity relationship

  Presenter : Ninomiya Y., Watanabe H., Yamagishi T., Maruyama-Komoda T., Yamada T., Yamamoto H.
  Title : , Ecotoxicology and Environmental Safety, 282(116737): (2024)
• Developing a Passive Dosing Method for Acute Aquatic Toxicity Tests of Cationic Surfactant Benzalkoniums (BACs)

  Presenter : Do T., Hiki K., Watanabe H., Yamamoto H., Endo S.
  Title : , Environmental Science & Technology, 58(31):13678-13686 (2024)
• Freely dissolved concentration profile and Hyalella azteca toxicity of cationic surfactant C12-benzalkonium in spiked-sediment toxicity test

  Presenter : Yoshii S., Hiki K., Watanabe H., Yamamoto H., Endo S.
  Title : , Science of the Total Environment, 866:161226 (2023)
• Development of a microplate-based novel toxicity bioassay using Chlorophyta and Phaeophyceae macroalgae

  Presenter : Onduka T., Somiya R., Yamagishi T., Hano T., Yamamoto H., Mochida K.
  Title : , Ecotoxicology (2023)
• Influence of water exchange rates on toxicity and bioaccumulation of hydrophobic organic chemicals in sediment toxicity tests

  Presenter : Hiki K., Fischer F., Nishimori T., Endo S., Watanabe H., Yamamoto H.
  Title : , Environmental Science: Processes & Impacts (2023)
• Environmental RNA as a Noninvasive Tool for Assessing Toxic Effects in Fish: A Proof-of-concept Study Using Japanese Medaka Exposed to Pyrene

  Presenter : Hiki K., Yamagishi T., Yamamoto H.
  Title : , Environmental Science & Technology, 57(34):12654-12662 (2023)
• Concentration and leachability of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its quinone transformation product (6PPD-Q) in road dust collected in Tokyo, Japan

  Presenter : Hiki K., Yamamoto H.
  Title : , Environmental Pollution, 302:119082 (2022)
• Severity classification of clinical signs and defining the moribund state as an experimental endpoint for acute toxicity testing using Japanese medaka (Oryzias latipes)

  Presenter : Yamagishi T., Kawano M., Watanabe H., Yagi A., Shintaku Y., Ohno K., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry, 41(4):1089-1095 (2022)
• 3D reconstructed brain images reveal the possibility of the ogg1 gene to suppress the irradiation-induced apoptosis in embryoni cbrain in medaka (Oryzias latipes)

  Presenter : YASUDA T., Li D., Kakimoto F., Mitani H., Yamamoto H., Ishikawa-Fujiwara T., Todo T., Oda S.
  Title : , Journal of Radiation Research, 2022:1-12 (2022)
• Potential differences in chitin synthesis ability cause different sensitivities to diflubenzuron among three strains of Daphnia magna

  Presenter : KATO K., Okamura K., Hiki K., Kintsu H., Nohara K., Yamagishi T., Nakajima N., Watanabe H., Yamamoto H.
  Title : , Aquatic Toxicology, 243(106071): (2022)
• Comparison of Species Sensitivity Distributions for Sediment-Associated Nonionic Organic Chemicals Through Equilibrium Partitioning Theory and Spiked-Sediment Toxicity Tests with Invertebrates

  Presenter : Hiki K., Iwasaki Y., Watanabe H., Yamamoto H.
  Title : , Environmental Toxicology and Chemistry, 41(412):462-473 (2022)
• Propidium iodide staining and flow cytometry-based assessment of heavy metal impact on marine phytoplankton

  Presenter : Ota S., Fuchida S., Yamaguchi H., Yamagishi T., Yamamoto H., Koshikawa H., Kawachi M.
  Title : , Cytologia, 87(2):177-187 (2022)
• Comparing 10‐ and 28‐Day Sediment Toxicity and Bioaccumulation of Fluoranthene in Hyalella azteca Using Passive Sampling Techniques

  Presenter : Nishimori T., Hiki K., Fischer F., Endo S., Yamamoto H., Watanabe H.
  Title : , Environmental Toxicology and Chemistry (2022)
• Quantitative analyses of misclassification rates in the hazard classification of environmental chemicals: Evaluation of procedures for deriving predicted no-effect concentrations in the Chemical Substance Control Law in Japan

  Presenter : Hayashi T., Furuhama A., Yokomizo H., Yamamoto H.
  Title : , Risk analysis (2022)
• Spatiotemporal distribution of hydrophobic organic contaminants in spiked-sediment toxicity tests: Measuring total and freely dissolved concentrations in pore and overlying water

  Presenter : Hiki K., Fischer F., Nishimori T., Watanabe H., Yamamoto H., Endo S.
  Title : , Environmental Toxicology and Chemistry (2021)
• Toxicity assessment of typical polycyclic aromatic hydrocarbons to Daphnia magna and Hyalella azteca in water-only and sediment-water exposure systems

  Presenter : Tani K., Watanabe H., Noguchi M., Hiki K., Yamagishi T., Yamamoto H.
  Title : , Science of the Total Environment, 784(147156): (2021)
• Sources of variation in sediment toxicity of hydrophobic organic chemicals: Meta-analysis of 10-14-day spiked-sediment tests with Hyalella azteca and Chironomus dilutus

  Presenter : Hiki K., Watanabe H., Yamamoto H.
  Title : , Integrated Environmental Assessment and Management, 17(5):1003-1013 (2021)
• Generating accurate in silico predictions of acute aquatic toxicity for a range of organic chemicals: Towards similarity-based machine learning methods

  Presenter : Gajewicz-Skretna A., Furuhama A., Yamamoto H., Suzuki N.
  Title : , Chemosphere, 280(2021): (2021)
• Aquatic toxicity (Pre)screening strategy for structurally diverse chemicals: global or local classification tree models?

  Presenter : Gajewicz-Skretna A., Gromelski M., Wyrzykowska E., Furuhama A., Yamamoto H., Suzuki N.
  Title : , Ecotoxicology and Environmental Safety, 208(2021): (2021)
• Quantitative structure-activity relationship and a category approach to support algal toxicity assessment of human pharmaceuticals

  Presenter : Yamada T., Kawamura T., Maruyama T., Kurimoto M., Yamamoto H., Katsutani S., Hirose A.
  Title : , Fundamental Toxicological Sciences, 8(7):195-204 (2021)
• Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

  Presenter : Katsiadaki I., Ellis T., Andersen L., Antczak P., Burden N., Fisher T., Green C., Labram B., Pearson A., Peersen K., Pickford D., Ramsden C., Rønneseth A., Ryder K., SackerD., Stevens C., Watanabe H., Yamamoto H., Sewell F., Hawkins P., Rufli H., Hnady R.D., Maynard S. K., Jacobs M. N.
  Title : , Ecotoxicology and Environmental Safety, 223(2021):112585 (2021)
• Differential heavy metal sensitivity in seven algal species from the NIES culture collection based on delayed fluorescence assays

  Presenter : Ota S., Yamaguchi H., Vanel F., Fuchida S., Koshikawa H., Yamagishi T., Yamamoto H., Kawachi M.
  Title : , Phycological Research, 68(1):41-49 (2020)
• Comparative genome analysis of test algal strain NIVA-CHL1 (Raphidocelis subcapitata) maintained in microalgal culture collections worldwide

  Presenter : Yamagishi T., Yamaguchi H., Suzuki S., Yoshikawa M. , Jameson I., Lorenz M., Nobles D.R., Campbell C., Seki M., Kawachi M., Yamamoto H.
  Title : , PLOS ONE, 15(11):e0241889 (2020)
• Production of genome-edited Daphnia for heavy metal detection by fluorescence

  Presenter : Arao T., Kato Y., Nong Q.D. , Yamamoto H., Watanabe H., Matsuura T., Tatarazako N., Tani K., Okamoto A., Matsumoto T., Watanabe H.
  Title : , Scientific Reports, 10(21490):1-10 (2020)
• Development of QSAAR and QAAR models for predicting fish early-life stage toxicity with a focus on industrial chemicals

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Title : , SAR and QSAR in Environmental Research , 30(11):825-846 (2019)
• Whole transcriptome analysis of an estuarine amphipod exposed to highway road dust

  Presenter : Hiki K., Nakajima F., Tobino T., Watanabe H., Yamamoto H.
  Title : , Science of the Total Enviroment, 675:141-150 (2019)
• Development of models to predict fish early-life stage toxicity from acute Daphnia magna toxicity

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Title : , SAR and QSAR in Environmental Research, 29(9):725-742 (2018)
• Contribution of inorganic and organic components to sorption of neutral and ionizable pharmaceuticals by sediment/soil

  Presenter : Yamamoto H., Takemoto K., Tamura I., Shin-oka N., Nakano T., Nishida M., Honda Y., Moriguchi S., Nakamura Y.
  Title : , Environmental Science and Pollution Research, 25(8):7250-7261 (2017)
• External validation of acute-to-chronic models for estimation of reproductive toxicity to Daphnia magna

  Presenter : Furuhama A., Hayashi T., Yamamoto H., Tatarazako N.
  Title : , SAR and QSAR in Environmental Research, 28(9):765-781 (2017)
• Contribution of pharmaceuticals and personal care products (PPCPs) to whole toxicity of water samples collected in effluent-dominated urban streams

  Presenter : Tamura I., Yasuda Y., Kagota, K., Nakada N., Kumar V., Kameda Y., Kimura K., Tatarazako N., Yamamoto H.
  Title : , Ecotoxicity and Environmental Safety, 144:338-350 (2017)
• Ecotoxicity and screening level ecotoxicological risk assessment of five antimicrobial agents: triclosan, triclocarban,resorcinol, phenoxyethanol and p-thymol

  Presenter : Yamamoto H., Tamura I., Kagota K., Yasuda Y., Yoneda S., Morita J., Nakada N., Kameda Y., Kimura K., Tatarazako N., Yamamoto H.
  Title : , Applied Toxicology (2012)
• The effects of pH on fluoxetine in Japanese medaka(Oryzias latipes): Acute toxicity in fish larvae and bioaccumulation in juvenile fish

  Presenter : Yamamoto H., Nakamura Y., Yamamoto H., Sekizawa J., Kondo T., Hirai N., Tatarazako N.
  Title : , Chemosphere, 70:865-873 (2008)
• Initial ecological risk assessment of eight selected human pharmaceuticals in Japan

  Presenter : Yamamoto H., Yamamoto H., Nakamura Y., Nakamura Y., Kitani C., Imari T., Sekizawa J., Takao Y., Yamashita N., Hirai N., Oda S., Tatarazako N.
  Title : , Environ.Sci., 14(4):177-193 (2007)
• Preliminary ecological risk assessment of butylparaben and benzylparaben 1.Removal efficiency in wastewater treatment, Acute/Chronic toxicity for aquatic organisms, and effects on medaka gene expression

  Presenter : Yamamoto H., Koshio M., Yamamoto H., Watanabe M., Hirata Y., Nakamura Y., Nakamura Y., Kitani C., Sekizawa J., Uchida M., Nakamura H., Kagami Y., Hirai N., Tatarazako N.
  Title : , Environ.Sci., 14((Suppl.)):73-87 (2007)

• Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development

  Presenter : Toyota K., Watanabe H., Hirano M., Abe R., Miyakawa H., Song Y., Sato T., Miyagawa S., Tollefsen K. E., Yamamoto H., Tatarazako N., Iguchi T.
  Title : , Aquatic Toxicology, 243(106058): (2022)
• International Contributions in Preventing Environmental Pollution by Chemical Substances, Challenges in Assessing the Unknown Toxicity of Chemical Substances

  Presenter : Chemicals Evaluation Office, Yamamoto H.
  Title : , JAPAN Environmental Quarterly, 26:8 (2021)

• Ecotoxicological Bioassay Using Marine Algae for Deep-Sea Mining

  Presenter : Yamagishi T., Ota S., Yamaguchi H., Koshikawa H., Tatarazako, N., Yamamoto H., Kawachi M.
  Title : , Environmental Issues of Deep-Sea Mining: Impacts, Consequences and Policy Perspectives (2019)

• The complete mitochondrial genome of water flea Ceriodaphnia dubia (Crustacea: Cladocera) NIES strain

  Presenter : Hiki K., Oka K., Nakajima N., Watanabe H., Yamamoto H., Yamagishi T.
  Title : , Mitochondrial DNA Part B: Resources, 8(8):831-835 (2023)
• The Tire-Derived Chemical 6PPD-quinone Is Lethally Toxic to the White-Spotted Char Salvelinus leucomaenis pluvius but Not to Two Other Salmonid Species

  Presenter : Hiki K., Yamamoto H.
  Title : , Environmental Science & Technology Letters, 9(12):1050-1055 (2022)
• Strategy for development of quantitative structure-activity-activity relationship models for chronic fish toxicity: prediction of early-life stage toxicity to Oryzias latipes from acute Daphnia magna toxicity

  Presenter : Furuhama A., Hayashi T. I., Yamamoto H.
  Title : , Japan Journal of Environmental Toxicology, 24:33-42 (2021)
• The complete mitochondrial genome of the non-biting midge Chironomus yoshimatsui (Diptera: Chironomidae)

  Presenter : Hiki K., Oka K., Nakajima N., Yamamoto H., Yamagishi T., Sugaya Y.
  Title : , Mitochondrial DNA Part B, 6(10):2995-2996 (2021)
• Acute Toxicity of a Tire Rubber-Derived Chemical, 6PPD Quinone, to Freshwater Fish and Crustacean Species

  Presenter : Hiki K., Asahina K., KATO K., Yamagishi T., Omagari R., Iwasaki Y., Watanabe H., Yamamoto H.
  Title : , Environmental Science & Technology Letters, 8(9):779-784 (2021)
• Multivariate Analysis of Water Quality and Ecotoxicity to Aquatic Species in the Yoshino River and the Yodo River Basin, Japan

  Presenter : Tamura I., Hayashi T., Nishi-ie S., Enyama M., Mitsuyama M., Tatarazako N., Yamamoto H.
  Title : , 学会誌「EICA」, 23(2,3):75-85 (2018)

Research Result (Presentation)

• all
• Research Presentation
• Research Lecture

• Research Lecture
  Environmental risk assessment of chemical mixtures considering their mode of action, structure, and exposure profile

  Presenter : Yamamoto H., Watanabe H., Oda Y., Yamagishi T., Hiki K., Imaizumi Y., Yokomizo H., Ozawa F., Ohno K.
  Name of Society : The 52nd Annual Meeting of the Japan Society of Toxicology (2025)
  Name of Proceedings : The Journalof Toxicological Sciences, 50(Supplement 1):S42
• Research Presentation
  LC5096h/LC5024h ratio derived from fish embryo acute toxicity test supports defining its applicability domain as alternative to acute fish toxicity test.

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Name of Society : The 4th Joint Conference on Environmental Chemicals (2025)
  Name of Proceedings : Abstracts
• Research Presentation
  The Zebrafish Extended One Generation Reproduction Test (ZEOGRT) - Experiences and Current Results from the Validation Exercise

  Presenter : Teigeler M., Eilebrecht E., Franzen K., Cahill B., Maunder R.J., Yamagishi T., Watanabe H., Yamamoto H., Holbech H., Schaudien D., Maack G., Walter-Rohde S.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 200-201
• Research Presentation
  Identification of Chemical Substances with Ecdysteroid Activity in Daphnia magna using in Silico Analysis, in Vitro and in Vivo Assays

  Presenter : Watanabe H., Oda Y., Abe R., Yamamoto H.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 205
• Research Presentation
  Ecological Risk Assessment of Human Pharmaceuticals Detected in Japan: Seasonal and Temporal Variations

  Presenter : Yamamoto H., Ninomiya Y., Watanabe H., Yamagishi T., Kobayashi N., Yamada T.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 968
• Research Presentation
  Performance Evaluation of QSAR Model "KATE2020" in Algal Toxicity Prediction using CSCL Newly Announced Chemical Substances as validation Set

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 112
• Research Presentation
  Ecotoxicity Testing of Cationic Surfactant Benzalkoniums (BACs) Using a Novel Passive Dosing Method

  Presenter : Do A.T.N., Hiki K., Watanabe H., Yamamoto H., Endo S.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 211
• Research Presentation
  Ecological Risk Assessment of Sulfa Drugs: A Case Study Using a Component Based Approach for Chemical Mixtures

  Presenter : Ozawa F., Nakajima T., Yoshizawa A., Machi S., Yamamoto H., Ohno K.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 966
• Research Presentation
  Development of "KATE2025": An Updated QSAR Model for Ecotoxicity Prediction and Comparative Evaluation With Previous Versions

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : -
• Research Presentation
  A novel metric to define the applicability domain of the fish embryo acute toxicity test as an alternative to the acute fish toxicity test

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Name of Society : ETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 14
• Research Presentation
  Ecotoxicity of antimicrobials in potentially sensitive species such as cyanobacteria, algae and protozoa

  Presenter : Yamamoto H., Oda Y., Watanabe H., Yamagishi T., Hiki K., Sugiura T., Nagao A., Ohno K.
  Name of Society : SETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 75
• Research Presentation
  Proposal of Ceriodaphnia dubia and Moina macrocopa as new daphnid test species in OECD test guideline

  Presenter : Watanabe H., Oda Y., Yamamoto H.
  Name of Society : SETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 154
• Research Presentation
  Experimental Validation of a Novel Metric, LC5096h/LC5024h Ratio, to Define the Applicability Domain of the Fish Embryo Test as an Alternative to Acute Fish Toxicity: A Case Study with 10 chemicals.

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Name of Society : SETAC North America 46th Annual Meeting. (2025)
  Name of Proceedings : Abstracts
• Research Presentation
  Differential acute lethality of the tire-derived chemical 6PPD-quinone to native Japanese salmonids

  Presenter : Hiki K., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 14th Biennial Meeting (2024)
  Name of Proceedings : Abstracts
• Research Presentation
  Analysis of environmental RNA in fish toxicity test with pyrene: a non-invasive approach

  Presenter : Hiki K., Yamagishi T., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 14th Biennial Meeting (2024)
  Name of Proceedings : Abstracts
• Research Presentation
  Concentration profiles of organic chemicals across sediment-water interface: Experimental and modeling approaches in spiked-sediment toxicity tests

  Presenter : Hiki K., Fischer F., Nishimori T., Yoshii S., Watanabe H., Endo S., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 14th Biennial Meeting (2024)
  Name of Proceedings : Abstracts
• Research Presentation
  Mixture effects of dialkylesters of phthalic acids (PAEs) on aquatic organisms based on predicted environmental exposure profiles

  Presenter : Oda Y., Imaizumi Y., Watanabe H., Hiki K., Yamagishi T., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (ISTA21) (2024)
  Name of Proceedings : -
• Research Presentation
  Effects of tire-derived chemical 6PPD-quinone on mitochondrial function in salmonid fish species

  Presenter : Hiki K., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (2024)
  Name of Proceedings : Abstracts, 99
• Research Presentation
  Application of AmpliSeq to environmental RNA may enable non-invasive assessments of various activities in fish

  Presenter : Hiki K., Hayashi T., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (2024)
  Name of Proceedings : Abstracts, 56
• Research Presentation
  How much known chemical substances in receiving water can explain the measured toxicity to alga, daphnid and fish?

  Presenter : Watanabe H., Nakajima D., Yamagishi T., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (ISTA21) (2024)
  Name of Proceedings : Abstracts, 70
• Research Presentation
  A novel approach for categorizing mode of action of chemicals by utilizing time-to-death observed in the fish acute toxicity test

  Presenter : Huang R., Yamagishi T., Hiki K., Ohno K., Watanabe H., Yamamoto H.
  Name of Society : 3rd Joint Concerence on Environmental Chemicals (2024)
  Name of Proceedings : Abstract
• Research Presentation
  Update to Ecotoxicity Prediction Model KATE2020 version 5.0 and its Predictive Performance Evaluation

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Research Presentation
  Toward the Tier Two Environmental Risk Assessment of Groups of Chemicals: A Case Study on Sulfa Drugs

  Presenter : Ozawa F., Watanabe H., Yamagishi T., Sato R., Maichi S., Yamamoto H., Ohno K.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Research Presentation
  Ecological risk assessment of human pharmaceuticals detected in Japan and establishment of ecotoxicity database

  Presenter : Yamamoto H., Ninomiya Y., Watanabe H., Yamagishi T., Kobayashi N., Ikarashi Y., Yamada, Hirose A.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Research Presentation
  Assessing the applicability domain of fish embryo toxicity test as alternatives of fish acute toxicity test, utilizing time-to-death in FET test

  Presenter : Huang R., Yamagishi T., Watanabe H., Ohno K., Yamamoto H.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Research Presentation
  Innovative ecological impact assessment using life-table response experiments and interstage flow matrices: Ecotoxicity of phthalate esters with different alkyl chain length

  Presenter : Yokomizo H., Tsuzuki Y., Kamo M., Takada T., Oda Y., Watanabe H., Yamamoto H.
  Name of Society : The Joint Meeting of the Annual Meeting of the Society of Population Ecology and Taiwan-Japan Ecology Workshop 2024 (2024)
  Name of Proceedings : Abstracts, 58-59
• Research Presentation
  Predictive Performance Evaluation of Ecotoxicity Prediction Model "KATE2020" Using Newly Announced Chemical Substances As Validation Set

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 560
• Research Presentation
  Characterization of Structural Similarity and Mode of Action of Chemicals with High Reproductive Toxicity to Daphnia magna

  Presenter : Watanabe H., Itami Y., Ninomiya Y., Sugiura T., Yamamoto H., Ohno K.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 348
• Research Presentation
  Development of Short-Term Screening Assay System for Detecting Anti-Juvenile Hormone (JH) Activity: JH Receptor Antagonists and JH Biosynthesis Inhibitor

  Presenter : Oda Y., Watanabe H., Takahata Y., Miyakawa H., Yamamoto H.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 78
• Research Presentation
  Evaluation of the Mode of Action (MoA) of Chemicals Based on Time-to- Death Data Obtained from Fish Embryo Acute Toxicity (FET) Test

  Presenter : Huang R., Yamagishi T., Watanabe H., Hiki K., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 160
• Research Presentation
  Identification of causative toxicants in river waters using bioassays with alga and daphnid and multiple-component chemical analysis

  Presenter : Watanabe H., Yamagishi T., Omagari R., Nakajima D., Yamamoto H.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstracts, 20
• Research Presentation
  New OECD Test Guideline Proposal for Sediment-Water Amphipod Toxicity Test

  Presenter : Hiki K., Watanabe H., Yamamoto H., Pandard P.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstracts, 97
• Research Presentation
  Mixture Effects of Phthalate Esters and Their Subgrouping Based on Toxicity Profiles

  Presenter : Yamamoto H., Oda Y., Watanabe H., Yamagishi T., Hiki K., Ozawa F., Ohno K.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstracts, 117
• Research Presentation
  External Validation and Characterization of Ecotoxicity Prediction QSAR Model KATE2020

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstract Book, 388-389
• Research Presentation
  Ecotoxicity characterization of pharmaceuticals in relation to physiological responses of algae for sufficiently conservative environmental risk assessment using in silico tools

  Presenter : Ninomya Y., Watanabe H., Yamagishi T., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 2022 Virtual Meeting (2022)
  Name of Proceedings : -
• Research Lecture
  Potential use of in silico methods for the ecological risk assessment in the chemical management in Japan

  Presenter : Yamamoto H.
  Name of Society : 2022 ICCA-LRI and NITE Workshop (2022)
  Name of Proceedings : -
• Research Presentation
  Concentration of N-(1,3-dimethylbutyl)-n′-Phenyl-P-Phenylendiamine-Quinone (6PPD-Q) in Road Dust and Its Association With Environmental Factors

  Presenter : Hiki K., Yamamoto H.
  Name of Society : SETAC Europe 32nd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 523
• Research Presentation
  Effect of Water Exchange Rate in Spiked-Sediment Toxicity Tests With Hyalella azteca on Behavior and Bioaccumulation of Hydrophobic Organic Chemicals

  Presenter : Hiki K., Fischer F., Nishimori T., Endo S., Watanabe H., Yamamoto H.
  Name of Society : SETAC Europe 32nd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 128
• Research Presentation
  Sensitivity Response Changes of Microbe-Associated Daphnia magna under Organophosphate Stress

  Presenter : Villegas V., Yamagishi T., Watanabe H., Yamamoto H.
  Name of Society : The 56th Annual Conference of Japan Society on Water Environment (2022)
  Name of Proceedings : Proceeding of the 56th Annual Conference of Japan Society on Water Environment, 333
• Research Presentation
  Comparison of headspace and conventional passive dosing techniques to prepare aquatic solution of selected semi-volatile and highly volatile organic chemicals for aquatic toxicity tests with D. magna

  Presenter : Lu Y., Yamagishi T., Watanabe H., Yamamoto H.
  Name of Society : The 56th Annual Conference of Japan Society on Water Environment 2022 (2022)
  Name of Proceedings : Proceeding of the 56th Annual Conference of Japan Society on Water Environment 2022, 332
• Research Presentation
  Various clinical signs of Japanese medaka (Oryzias latipes) in fish acute toxicity test and their link with moribundity and death

  Presenter : Yamagishi T., Watanabe H., Yamamoto H.
  Name of Society : SETAC North America 43rd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 215
• Research Presentation
  Development and assessment of Adverse Outcome Pathways for juvenile hormone mediated effects of environmental stimuli and chemicals in cladoceran

  Presenter : Watanabe H., Toyota K., Hirano M., Abe R., Miyakawa H., Song Y., Tollefsen K.E., Yamamoto H., Iguchi T.
  Name of Society : SETAC North America 43rd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 46
• Research Presentation
  Recent trend in OECD fish tests for chemical management and the test method development in NIES

  Presenter : Yamamoto H., Watanabe H., Yamagishi T.
  Name of Society : 第27回小型魚類研究会 (2021)
  Name of Proceedings : The 27th Japanese Medaka and Zebrafish Meeting, 39
• Research Lecture
  Current concern of ecological/health effects of microplastics: what has been revealed and what are still unrevealed

  Presenter : Yamamoto H.
  Name of Society : Agenda of the 3rd China-Japan Experts Dialogue Platform Meeting on Marine Debris Cooperation and the 3rd China-Japan Marin Debris Workshop (2021)
  Name of Proceedings : -
• Research Presentation
  Does the Pore Water Free Concentration Explain Everything in Sediment Contact Assays with Hydrophobic Organic Chemicals?

  Presenter : Endo S., Hiki K., Fischer F., Watanabe H., Yamamoto H., Nakajima F.
  Name of Society : SETAC North America 41st Annual Meeting (SciCon2) (2020)
  Name of Proceedings : Abstract book, 317
• Research Presentation
  Short-term chronic toxicity of acrylic acid and acrylates esters to alga, daphnid and fish

  Presenter : Watanabe H., Kawano M., Yamagishi T., Ozawa F., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 41st Annual Meeting (2020)
  Name of Proceedings : Abstracts, 142
• Research Presentation
  Models for predicting fish early-life stage toxicity of general industrial chemicals

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Name of Society : Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2019) (2019)
  Name of Proceedings : Abstracts, 18
• Research Presentation
  Acute aquatic toxicity of diverse industrial organic chemicals: Is there need for new in silico models?

  Presenter : Gajewicz A., Furuhama A., Yamamoto H., Suzuki N.
  Name of Society : Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2019) (2019)
  Name of Proceedings : Abstracts, 19
• Research Presentation
  External validation of the ecotoxicity prediction system, KATE2017

  Presenter : Furuhama A., Ohno K., Yamamoto H.
  Name of Society : Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2019) (2019)
  Name of Proceedings : Abstracts, 51
• Research Presentation
  RNA Seq analysis of estuarine amphipods exposed to highway road dust

  Presenter : Hiki K., Nakajima F., Tobino T., Watanabe H., Yamamoto H.
  Name of Society : SETAC Europe 29th Annual Meeting (2019)
  Name of Proceedings : Abstracts, 444
• Research Presentation
  Validation of the protocol of juvenile hormone activity screening assay (JHASA) proposed to OECD

  Presenter : Abe R., Watanabe H., Ogawa M., Adachi R., Okamura T., Matsumoto T., Okamoto A., Tatarazako N., Yamamoto H.
  Name of Society : SETAC Europe 29th Annual Meeting (2019)
  Name of Proceedings : Abstracts
• Research Presentation
  Case Studies of Toxicity Reduction Evaluation/Toxicity Identification Evaluation on Industrial Effluent in Japan

  Presenter : Watanabe H., Yamagishi T., Abe R., Tatarazako N., Yamamoto H.
  Name of Society : IWA World Water Congress and Exhibition 2018 (2018)
  Name of Proceedings : -
• Research Presentation
  Fish early-life stage toxicity predicted from acute Daphnia magna toxicity and molecular descriptors

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Name of Society : 18th International Conference on QSAR in Environmental and Health Sciences (QSAR2018) (2018)
  Name of Proceedings : Abstracts, 52
• Research Presentation
  Chronic toxicity assessment of Ni contaminated rivers in Japan using Ceriodaphnia dubia for development of biotic ligand model for Japanese surface waters

  Presenter : Watanabe H., Noguchi M., Misaki T., Oda S., Matsuzaki K., Yamamoto H.
  Name of Society : SETAC Europe 28th Annual Meeting (2018)
  Name of Proceedings : Abstracts, 313
• Research Presentation
  Effects of physico-chemical characteristics of formulated sediment on the survival and growth of amphipods Grandidierella japonica and Hyalella azteca

  Presenter : Hiki K., Watanabe H., Yamamoto H., Nakajima F., Tobino T.
  Name of Society : SETAC North America 39th Annual Meeting (2018)
  Name of Proceedings : Abstracts, 261
• Research Presentation
  Development of chronic aquatic toxicity models based on an interspecies relationship and molecular descriptors

  Presenter : Furuhama A., Hayashi T., Yamamoto H., Tatarazako N.
  Name of Society : CMTPI-2017 9th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (2017)
  Name of Proceedings : Abstracts, 26
• Research Lecture
  Water Quality Standards and Risk Assessment in Japan

  Presenter : Yamamoto H.
  Name of Society : The 13th Tripartite Presidents Meeting among CRAES, NIES, and NIER (TPM13) (2016)
  Name of Proceedings : Proceeding
• Research Presentation
  Multivariable analysis of ecotoxicity and basic water quality parameters in two watershed areas in Japan: effects of concentration process

  Presenter : Yamamoto H., Mitsuyama M., Nishi-ie S., Enyama M., Shin-oka N., Tamura I., Tatarazako N.
  Name of Society : 7th SETAC World Congress/37th SETAC North America Annual Meeting (2016)
  Name of Proceedings : Abstracts

• Ecotoxicity Testing of Cationic Surfactant Benzalkoniums (BACs) Using a Novel Passive Dosing Method

  Presenter : Do A.T.N., Hiki K., Watanabe H., Yamamoto H., Endo S.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 211
• Concentration profiles of organic chemicals across sediment-water interface: Experimental and modeling approaches in spiked-sediment toxicity tests

  Presenter : Hiki K., Fischer F., Nishimori T., Yoshii S., Watanabe H., Endo S., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 14th Biennial Meeting (2024)
  Name of Proceedings : Abstracts
• Mixture effects of dialkylesters of phthalic acids (PAEs) on aquatic organisms based on predicted environmental exposure profiles

  Presenter : Oda Y., Imaizumi Y., Watanabe H., Hiki K., Yamagishi T., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (ISTA21) (2024)
  Name of Proceedings : -
• Application of AmpliSeq to environmental RNA may enable non-invasive assessments of various activities in fish

  Presenter : Hiki K., Hayashi T., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (2024)
  Name of Proceedings : Abstracts, 56
• How much known chemical substances in receiving water can explain the measured toxicity to alga, daphnid and fish?

  Presenter : Watanabe H., Nakajima D., Yamagishi T., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (ISTA21) (2024)
  Name of Proceedings : Abstracts, 70
• A novel approach for categorizing mode of action of chemicals by utilizing time-to-death observed in the fish acute toxicity test

  Presenter : Huang R., Yamagishi T., Hiki K., Ohno K., Watanabe H., Yamamoto H.
  Name of Society : 3rd Joint Concerence on Environmental Chemicals (2024)
  Name of Proceedings : Abstract
• Ecotoxicity characterization of pharmaceuticals in relation to physiological responses of algae for sufficiently conservative environmental risk assessment using in silico tools

  Presenter : Ninomya Y., Watanabe H., Yamagishi T., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 2022 Virtual Meeting (2022)
  Name of Proceedings : -
• Concentration of N-(1,3-dimethylbutyl)-n′-Phenyl-P-Phenylendiamine-Quinone (6PPD-Q) in Road Dust and Its Association With Environmental Factors

  Presenter : Hiki K., Yamamoto H.
  Name of Society : SETAC Europe 32nd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 523
• Effect of Water Exchange Rate in Spiked-Sediment Toxicity Tests With Hyalella azteca on Behavior and Bioaccumulation of Hydrophobic Organic Chemicals

  Presenter : Hiki K., Fischer F., Nishimori T., Endo S., Watanabe H., Yamamoto H.
  Name of Society : SETAC Europe 32nd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 128
• Sensitivity Response Changes of Microbe-Associated Daphnia magna under Organophosphate Stress

  Presenter : Villegas V., Yamagishi T., Watanabe H., Yamamoto H.
  Name of Society : The 56th Annual Conference of Japan Society on Water Environment (2022)
  Name of Proceedings : Proceeding of the 56th Annual Conference of Japan Society on Water Environment, 333
• Comparison of headspace and conventional passive dosing techniques to prepare aquatic solution of selected semi-volatile and highly volatile organic chemicals for aquatic toxicity tests with D. magna

  Presenter : Lu Y., Yamagishi T., Watanabe H., Yamamoto H.
  Name of Society : The 56th Annual Conference of Japan Society on Water Environment 2022 (2022)
  Name of Proceedings : Proceeding of the 56th Annual Conference of Japan Society on Water Environment 2022, 332
• Recent trend in OECD fish tests for chemical management and the test method development in NIES

  Presenter : Yamamoto H., Watanabe H., Yamagishi T.
  Name of Society : 第27回小型魚類研究会 (2021)
  Name of Proceedings : The 27th Japanese Medaka and Zebrafish Meeting, 39
• Does the Pore Water Free Concentration Explain Everything in Sediment Contact Assays with Hydrophobic Organic Chemicals?

  Presenter : Endo S., Hiki K., Fischer F., Watanabe H., Yamamoto H., Nakajima F.
  Name of Society : SETAC North America 41st Annual Meeting (SciCon2) (2020)
  Name of Proceedings : Abstract book, 317
• Models for predicting fish early-life stage toxicity of general industrial chemicals

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Name of Society : Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2019) (2019)
  Name of Proceedings : Abstracts, 18
• Acute aquatic toxicity of diverse industrial organic chemicals: Is there need for new in silico models?

  Presenter : Gajewicz A., Furuhama A., Yamamoto H., Suzuki N.
  Name of Society : Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2019) (2019)
  Name of Proceedings : Abstracts, 19
• Case Studies of Toxicity Reduction Evaluation/Toxicity Identification Evaluation on Industrial Effluent in Japan

  Presenter : Watanabe H., Yamagishi T., Abe R., Tatarazako N., Yamamoto H.
  Name of Society : IWA World Water Congress and Exhibition 2018 (2018)
  Name of Proceedings : -
• Fish early-life stage toxicity predicted from acute Daphnia magna toxicity and molecular descriptors

  Presenter : Furuhama A., Hayashi T., Yamamoto H.
  Name of Society : 18th International Conference on QSAR in Environmental and Health Sciences (QSAR2018) (2018)
  Name of Proceedings : Abstracts, 52
• Development of chronic aquatic toxicity models based on an interspecies relationship and molecular descriptors

  Presenter : Furuhama A., Hayashi T., Yamamoto H., Tatarazako N.
  Name of Society : CMTPI-2017 9th International Symposium on Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (2017)
  Name of Proceedings : Abstracts, 26
• LC5096h/LC5024h ratio derived from fish embryo acute toxicity test supports defining its applicability domain as alternative to acute fish toxicity test.

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Name of Society : The 4th Joint Conference on Environmental Chemicals (2025)
  Name of Proceedings : Abstracts
• The Zebrafish Extended One Generation Reproduction Test (ZEOGRT) - Experiences and Current Results from the Validation Exercise

  Presenter : Teigeler M., Eilebrecht E., Franzen K., Cahill B., Maunder R.J., Yamagishi T., Watanabe H., Yamamoto H., Holbech H., Schaudien D., Maack G., Walter-Rohde S.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 200-201
• Identification of Chemical Substances with Ecdysteroid Activity in Daphnia magna using in Silico Analysis, in Vitro and in Vivo Assays

  Presenter : Watanabe H., Oda Y., Abe R., Yamamoto H.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 205
• Ecological Risk Assessment of Human Pharmaceuticals Detected in Japan: Seasonal and Temporal Variations

  Presenter : Yamamoto H., Ninomiya Y., Watanabe H., Yamagishi T., Kobayashi N., Yamada T.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 968
• Performance Evaluation of QSAR Model "KATE2020" in Algal Toxicity Prediction using CSCL Newly Announced Chemical Substances as validation Set

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 112
• Ecological Risk Assessment of Sulfa Drugs: A Case Study Using a Component Based Approach for Chemical Mixtures

  Presenter : Ozawa F., Nakajima T., Yoshizawa A., Machi S., Yamamoto H., Ohno K.
  Name of Society : SETAC Europe 35th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 966
• Development of "KATE2025": An Updated QSAR Model for Ecotoxicity Prediction and Comparative Evaluation With Previous Versions

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : -
• A novel metric to define the applicability domain of the fish embryo acute toxicity test as an alternative to the acute fish toxicity test

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Name of Society : ETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 14
• Ecotoxicity of antimicrobials in potentially sensitive species such as cyanobacteria, algae and protozoa

  Presenter : Yamamoto H., Oda Y., Watanabe H., Yamagishi T., Hiki K., Sugiura T., Nagao A., Ohno K.
  Name of Society : SETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 75
• Proposal of Ceriodaphnia dubia and Moina macrocopa as new daphnid test species in OECD test guideline

  Presenter : Watanabe H., Oda Y., Yamamoto H.
  Name of Society : SETAC North America 46th Annual Meeting (2025)
  Name of Proceedings : Abstracts, 154
• Experimental Validation of a Novel Metric, LC5096h/LC5024h Ratio, to Define the Applicability Domain of the Fish Embryo Test as an Alternative to Acute Fish Toxicity: A Case Study with 10 chemicals.

  Presenter : Huang R., Watanabe H., Ohno K., Yamamoto H., Yamagishi T.
  Name of Society : SETAC North America 46th Annual Meeting. (2025)
  Name of Proceedings : Abstracts
• Differential acute lethality of the tire-derived chemical 6PPD-quinone to native Japanese salmonids

  Presenter : Hiki K., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 14th Biennial Meeting (2024)
  Name of Proceedings : Abstracts
• Analysis of environmental RNA in fish toxicity test with pyrene: a non-invasive approach

  Presenter : Hiki K., Yamagishi T., Yamamoto H.
  Name of Society : SETAC Asia-Pacific 14th Biennial Meeting (2024)
  Name of Proceedings : Abstracts
• Effects of tire-derived chemical 6PPD-quinone on mitochondrial function in salmonid fish species

  Presenter : Hiki K., Yamamoto H.
  Name of Society : 21st International Symposium on Toxicity Assessment (2024)
  Name of Proceedings : Abstracts, 99
• Update to Ecotoxicity Prediction Model KATE2020 version 5.0 and its Predictive Performance Evaluation

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Toward the Tier Two Environmental Risk Assessment of Groups of Chemicals: A Case Study on Sulfa Drugs

  Presenter : Ozawa F., Watanabe H., Yamagishi T., Sato R., Maichi S., Yamamoto H., Ohno K.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Ecological risk assessment of human pharmaceuticals detected in Japan and establishment of ecotoxicity database

  Presenter : Yamamoto H., Ninomiya Y., Watanabe H., Yamagishi T., Kobayashi N., Ikarashi Y., Yamada, Hirose A.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Assessing the applicability domain of fish embryo toxicity test as alternatives of fish acute toxicity test, utilizing time-to-death in FET test

  Presenter : Huang R., Yamagishi T., Watanabe H., Ohno K., Yamamoto H.
  Name of Society : SETAC Europe 34th Annual Meeting (2024)
  Name of Proceedings : Abstracts
• Innovative ecological impact assessment using life-table response experiments and interstage flow matrices: Ecotoxicity of phthalate esters with different alkyl chain length

  Presenter : Yokomizo H., Tsuzuki Y., Kamo M., Takada T., Oda Y., Watanabe H., Yamamoto H.
  Name of Society : The Joint Meeting of the Annual Meeting of the Society of Population Ecology and Taiwan-Japan Ecology Workshop 2024 (2024)
  Name of Proceedings : Abstracts, 58-59
• Predictive Performance Evaluation of Ecotoxicity Prediction Model "KATE2020" Using Newly Announced Chemical Substances As Validation Set

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 560
• Characterization of Structural Similarity and Mode of Action of Chemicals with High Reproductive Toxicity to Daphnia magna

  Presenter : Watanabe H., Itami Y., Ninomiya Y., Sugiura T., Yamamoto H., Ohno K.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 348
• Development of Short-Term Screening Assay System for Detecting Anti-Juvenile Hormone (JH) Activity: JH Receptor Antagonists and JH Biosynthesis Inhibitor

  Presenter : Oda Y., Watanabe H., Takahata Y., Miyakawa H., Yamamoto H.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 78
• Evaluation of the Mode of Action (MoA) of Chemicals Based on Time-to- Death Data Obtained from Fish Embryo Acute Toxicity (FET) Test

  Presenter : Huang R., Yamagishi T., Watanabe H., Hiki K., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 45th Annual Meeting (2024)
  Name of Proceedings : Abstracts, 160
• Identification of causative toxicants in river waters using bioassays with alga and daphnid and multiple-component chemical analysis

  Presenter : Watanabe H., Yamagishi T., Omagari R., Nakajima D., Yamamoto H.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstracts, 20
• New OECD Test Guideline Proposal for Sediment-Water Amphipod Toxicity Test

  Presenter : Hiki K., Watanabe H., Yamamoto H., Pandard P.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstracts, 97
• Mixture Effects of Phthalate Esters and Their Subgrouping Based on Toxicity Profiles

  Presenter : Yamamoto H., Oda Y., Watanabe H., Yamagishi T., Hiki K., Ozawa F., Ohno K.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstracts, 117
• External Validation and Characterization of Ecotoxicity Prediction QSAR Model KATE2020

  Presenter : Itami Y., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 44th Annual Meeting (2023)
  Name of Proceedings : Abstract Book, 388-389
• Various clinical signs of Japanese medaka (Oryzias latipes) in fish acute toxicity test and their link with moribundity and death

  Presenter : Yamagishi T., Watanabe H., Yamamoto H.
  Name of Society : SETAC North America 43rd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 215
• Development and assessment of Adverse Outcome Pathways for juvenile hormone mediated effects of environmental stimuli and chemicals in cladoceran

  Presenter : Watanabe H., Toyota K., Hirano M., Abe R., Miyakawa H., Song Y., Tollefsen K.E., Yamamoto H., Iguchi T.
  Name of Society : SETAC North America 43rd Annual Meeting (2022)
  Name of Proceedings : Abstracts, 46
• Short-term chronic toxicity of acrylic acid and acrylates esters to alga, daphnid and fish

  Presenter : Watanabe H., Kawano M., Yamagishi T., Ozawa F., Ohno K., Yamamoto H.
  Name of Society : SETAC North America 41st Annual Meeting (2020)
  Name of Proceedings : Abstracts, 142
• External validation of the ecotoxicity prediction system, KATE2017

  Presenter : Furuhama A., Ohno K., Yamamoto H.
  Name of Society : Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (CMTPI-2019) (2019)
  Name of Proceedings : Abstracts, 51
• RNA Seq analysis of estuarine amphipods exposed to highway road dust

  Presenter : Hiki K., Nakajima F., Tobino T., Watanabe H., Yamamoto H.
  Name of Society : SETAC Europe 29th Annual Meeting (2019)
  Name of Proceedings : Abstracts, 444
• Validation of the protocol of juvenile hormone activity screening assay (JHASA) proposed to OECD

  Presenter : Abe R., Watanabe H., Ogawa M., Adachi R., Okamura T., Matsumoto T., Okamoto A., Tatarazako N., Yamamoto H.
  Name of Society : SETAC Europe 29th Annual Meeting (2019)
  Name of Proceedings : Abstracts
• Chronic toxicity assessment of Ni contaminated rivers in Japan using Ceriodaphnia dubia for development of biotic ligand model for Japanese surface waters

  Presenter : Watanabe H., Noguchi M., Misaki T., Oda S., Matsuzaki K., Yamamoto H.
  Name of Society : SETAC Europe 28th Annual Meeting (2018)
  Name of Proceedings : Abstracts, 313
• Effects of physico-chemical characteristics of formulated sediment on the survival and growth of amphipods Grandidierella japonica and Hyalella azteca

  Presenter : Hiki K., Watanabe H., Yamamoto H., Nakajima F., Tobino T.
  Name of Society : SETAC North America 39th Annual Meeting (2018)
  Name of Proceedings : Abstracts, 261
• Multivariable analysis of ecotoxicity and basic water quality parameters in two watershed areas in Japan: effects of concentration process

  Presenter : Yamamoto H., Mitsuyama M., Nishi-ie S., Enyama M., Shin-oka N., Tamura I., Tatarazako N.
  Name of Society : 7th SETAC World Congress/37th SETAC North America Annual Meeting (2016)
  Name of Proceedings : Abstracts

• Environmental risk assessment of chemical mixtures considering their mode of action, structure, and exposure profile

  Presenter : Yamamoto H., Watanabe H., Oda Y., Yamagishi T., Hiki K., Imaizumi Y., Yokomizo H., Ozawa F., Ohno K.
  Name of Society : The 52nd Annual Meeting of the Japan Society of Toxicology (2025)
  Name of Proceedings : The Journalof Toxicological Sciences, 50(Supplement 1):S42
• Potential use of in silico methods for the ecological risk assessment in the chemical management in Japan

  Presenter : Yamamoto H.
  Name of Society : 2022 ICCA-LRI and NITE Workshop (2022)
  Name of Proceedings : -
• Current concern of ecological/health effects of microplastics: what has been revealed and what are still unrevealed

  Presenter : Yamamoto H.
  Name of Society : Agenda of the 3rd China-Japan Experts Dialogue Platform Meeting on Marine Debris Cooperation and the 3rd China-Japan Marin Debris Workshop (2021)
  Name of Proceedings : -
• Water Quality Standards and Risk Assessment in Japan

  Presenter : Yamamoto H.
  Name of Society : The 13th Tripartite Presidents Meeting among CRAES, NIES, and NIER (TPM13) (2016)
  Name of Proceedings : Proceeding

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