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4. OKAMURA Kazuyuki

Researcher Name

OKAMURA Kazuyuki

Div (Section) name/title

Health and Environmental Risk Division(Molecular Pathology Section)/Senior Researcher

Research Subject

Clarification of the mechanisms of diseases induction by environmental exposure especially focused on cellular senescence and transgenerational epigenetic inheritance

Degree(s)

Doctor of Philosophy in Environmental Studies

Professional Qualification(s)

Biochemistry,Science,Medicine

Environmental Speciality Field

toxicology,chemical substance,Hygiene

Keyword(s)

epigenetics,cellular senescence,arsenic,transgenerational effect,tumor

Membership of Academic Society

The Japanese Society for Hygiene,The Japanese Cancer Association,The Molecular Biology Society of Japan,The Japanese Society for Epigenetics,The Japanese Society for DOHaD,Japanese Society of Immunotoxicology,The Japanese Society of Toxicology,Society for Senescence-Accelerated Mouse (SAM) Research

Research Subject

• Fiscal Year: 2025
  • 27216 : Research project on the health hazard assessment considering the real-life environment and vulnerability
  • 27382 : Basic research on the effects of environmental factors on the onset/progression of diseases
  • 27425 : Search for molecular targets to eliminate senescent cells induced by arsenic exposure
  • 27426 : Experimental study of the effects of LED light control on sleep and lifespan
• Fiscal Year: 2024
  • 26829 : Research project on the health hazard assessment considering the real-life environment and vulnerability
  • 26966 : Basic research on the effects of environmental factors on the onset/progression of diseases
  • 26988 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
  • 26989 : Search for molecular targets to eliminate senescent cells induced by arsenic exposure
  • 26990 : Experimental study of the effects of LED light control on sleep and lifespan
  • 27019 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
• Fiscal Year: 2023
  • 26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
  • 26514 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
  • 26516 : Search for molecular targets to eliminate senescent cells induced by arsenic exposure
  • 26517 : Experimental study of the effects of LED light control on sleep and lifespan
  • 26551 : Basic research on the effects of environmental factors on the onset/progression of diseases
  • 26659 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
• Fiscal Year: 2022
  • 25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
  • 26083 : Basic research on the effects of environmental factors on the onset/progression of diseases
  • 26135 : Elucidation of the mechanism of liver carcinogenesis via premature senescence of hepatocytes induced by arsenite exposure
  • 26136 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
  • 26220 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
• Fiscal Year: 2021
  • 25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
  • 25738 : Basic research on the effects of environmental factors on the onset/progression of diseases
  • 25741 : Elucidation of the mechanism of liver carcinogenesis via premature senescence of hepatocytes induced by arsenite exposure
  • 25801 : Analysis of mechanism of DNA methylation changes in next-generation sperm genome induced by gestational arsenic exposure
  • 25936 : Elucidation of the mechanisms of arsenic-induced cardiometabolic diseases
• Fiscal Year: 2020
  • 25099 : Research Program on Health and Environmental Safety
  • 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
  • 25196 : Project for the Promotion of Environmental Genomics Studies
  • 25250 : Studies on the Effects of Environmental Factors on the Onset/progression of Diseases
  • 25277 : Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
• Fiscal Year: 2019
  • 24696 : Research Program on Health and Environmental Safety
  • 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
  • 24837 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
  • 24838 : Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
  • 24858 : Project for the Promotion of Environmental Genomics Studies
  • 24891 : Studies on the Effects of Environmental Factors on the Onset/progression of Diseases
  • 24955 : Investigation of the mechanisms of arsenic-induced carcinogenesis via cellular senescence of fibroblast
• Fiscal Year: 2018
  • 24304 : Research project on health impacts of chemicals on children and future generations
  • 24355 : Research program on health and environmental safety
  • 24446 : Project for The Promotion of Environmental Genomics studies
  • 24455 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
  • 24498 : Investigation of the mechanisms of arsenic-induced carcinogenesis via cellular senescence of fibroblast
  • 24504 : Studies on the effects of environmental factors on the onset/progression of diseases
• Fiscal Year: 2017
  • 23824 : Research project on health impacts of chemicals on children and future generations
  • 23847 : Research program on health and environmental safety
  • 23948 : Studies on the effects of environmental factors on the onset/progression of diseases
  • 23967 : Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
  • 23970 : Project for The Promotion of Environmental Genomics studies
  • 24016 : The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
• Fiscal Year: 2016
  • 23414 : Research program on health and environmental safety
  • 23415 : Research project on health impacts of chemicals on children and future generations
  • 23484 : Project for The Promotion of Environmental Genomics studies
  • 23558 : Studies on the effects of environmental factors on the onset/progression of diseases
  • 23593 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
  • 23594 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
  • 23661 : The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
• Fiscal Year: 2015
  • 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
  • 23256 : Studies on multigenerational late-onset effects of environmental chemicals
  • 23257 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
  • 23258 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant female
  • 23259 : The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
  • 23277 : Establishment of an international cooperation for promoting arsenic research
• Fiscal Year: 2014
  • 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
  • 22719 : Studies on multigenerational late-onset effects of environmental chemicals
  • 22721 : Studies on epimutations that are involved in the transgenerational effects of environmental chemicals in mice
  • 22722 : Establishment of an international cooperation for promoting arsenic research
• Fiscal Year: 2013
  • 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
  • 22507 : Studies on multigenerational late-onset effects of environmental chemicals
• Fiscal Year: 2012
  • 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
  • 21986 : Studies of factors contributing to the regulation of epigenetics
• Fiscal Year: 2011
  • 21480 : Studies of factors contributing to the regulation of epigenetics
  • 21481 : Studies on the mechanism of transcription factor dependent effects of environmental chemicals

Research Result (Publication)

• all
• Original Paper
• Review

• Original Paper
  Sleep disruption with aging in senescence-accelerated mice-prone 8 (SAMP8) mice and analysis of factors associated with age-related sleep fragmentation using RNA sequencing of the hypothalamus

  Presenter : Okamura K., Yanagisawa R., Sato M., Suzuki T., Nakajima N., Tin-Tin-Win-Shwe, Koike E.
  Title : , Neurobiology of Sleep and Circadian Rhythms, 20(100142): (2026)
• Original Paper
  Sperm DNA methylation alterations induced by gestational arsenic exposure are established stepwise during spermatogenesis

  Presenter : Suzuki T., Okamura K., Nohara K.
  Title : , Environmental Health and Preventive Medicine, 31(43): (2026)
• Original Paper
  Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos

  Presenter : Nohara K., Suzuki T., Okamura K., Kawai T., Nakabayashi K.
  Title : , Epigenetics & Chromatin (2025)
• Original Paper
  Characteristics of Global Methylation Changes in F1 Mice Sperm DNA Induced by Gestational Arsenic Exposure Are Re-Established in F2 Somatic Cells but Not in F2 Germ Cells

  Presenter : Suzuki T., Okamura K., Nohara K.
  Title : , Genes to Cells, 30(3):e70022 (2025)
• Original Paper
  Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7

  Presenter : Okamura K., Sato M., Suzuki T., Nohara K.
  Title : , Environmental Health and Preventive Medicine (2024)
• Original Paper
  Potential differences in chitin synthesis ability cause different sensitivities to diflubenzuron among three strains of Daphnia magna

  Presenter : KATO K., Okamura K., Hiki K., Kintsu H., Nohara K., Yamagishi T., Nakajima N., Watanabe H., Yamamoto H.
  Title : , Aquatic Toxicology, 243(106071): (2022)
• Original Paper
  Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells

  Presenter : Okamura K., Sato M., Suzuki T., Nohara K.
  Title : , Toxicology and Applied Pharmacology, 454: (2022)
• Original Paper
  Identification by TCGA database search of five genes that are aberrantly expressed and involved in hepatocellular carcinoma potentially via DNA methylation changes

  Presenter : Matsushita J., Suzuki T., Okamura K., Ichihara G., Nohara K.
  Title : , Environmental Health and Preventive Medicine, 25: (2020)
• Original Paper
  Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways

  Presenter : Okamura K., Suzuki T., Nohara K.
  Title : , Toxicology and Applied Pharmacology (2020)
• Original Paper
  Gestational arsenic exposure and paternal intergenerational epigenetic inheritance.

  Presenter : Nohara K., Suzuki T., Okamura K.
  Title : , Toxicol Appl Pharmacol (2020)
• Original Paper
  Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice

  Presenter : Nohara K., Nakabayashi K., Okamura K., Suzuki T., Suzuki S., Hata K.
  Title : , Epigenetics & Chromatin, 13(53): (2020)
• Review
  Arsenic Exposure and Reproductive Toxicity

  Presenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
  Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019)
• Original Paper
  DNA methylation changes involved in the tumor increase in F2 males born to gestationally arsenite-exposed F1 male mice

  Presenter : Okamura K., Nakabayashi K., Kawai T., Suzuki T., Sano T., Hata K., Nohara K.
  Title : , Cancer Science, 110:2629-2642 (2019)
• Original Paper
  The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

  Presenter : Matsushita J., Okamura K., Nakabayashi K, Suzuki T., Horibe Y., Kawai T., Sakurai T., Yamashita S., Higami Y., Ichihara G., Hata K., Nohara K.
  Title : , BMC Cancer, 18:317 (2018)
• Review
  Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

  Presenter : Nohara K., Suzuki T., Okamura K., Matsushita J., Takumi S.
  Title : , Genes and Environment, 39(3): (2017)
• Original Paper
  Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells

  Presenter : Okamura K., Nohara K.
  Title : , Archives of Toxicology, 90(4):793-803 (2016)
• Original Paper
  Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring

  Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Michikawa T., Ito T., Shinjo K., Takumi S., Kondo Y., Hata K.
  Title : , Journal of Applied Toxicology, 36(1):105-112 (2015)
• Original Paper
  The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways

  Presenter : Takumi S., Okamura K., Yanagisawa H., Sano T., Kobayashi Y., Nohara K.
  Title : , Journal of Applied Toxicology, 760:1550-1556 (2014)
• Original Paper
  Inorganic arsenic exposure induces E2F-dependent G0/G1 arrest via an increase in retinoblastoma family protein p130 in B-cell lymphoma A20 cells.

  Presenter : Okamura K., Miki D., Nohara K.
  Title : , Genes to Cells, 18(10):839-849 (2013)
• Original Paper
  Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic

  Presenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
  Title : , Toxicological Sciences, 129:293-304 (2012)

• Sleep disruption with aging in senescence-accelerated mice-prone 8 (SAMP8) mice and analysis of factors associated with age-related sleep fragmentation using RNA sequencing of the hypothalamus

  Presenter : Okamura K., Yanagisawa R., Sato M., Suzuki T., Nakajima N., Tin-Tin-Win-Shwe, Koike E.
  Title : , Neurobiology of Sleep and Circadian Rhythms, 20(100142): (2026)
• Sperm DNA methylation alterations induced by gestational arsenic exposure are established stepwise during spermatogenesis

  Presenter : Suzuki T., Okamura K., Nohara K.
  Title : , Environmental Health and Preventive Medicine, 31(43): (2026)
• Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos

  Presenter : Nohara K., Suzuki T., Okamura K., Kawai T., Nakabayashi K.
  Title : , Epigenetics & Chromatin (2025)
• Characteristics of Global Methylation Changes in F1 Mice Sperm DNA Induced by Gestational Arsenic Exposure Are Re-Established in F2 Somatic Cells but Not in F2 Germ Cells

  Presenter : Suzuki T., Okamura K., Nohara K.
  Title : , Genes to Cells, 30(3):e70022 (2025)
• Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7

  Presenter : Okamura K., Sato M., Suzuki T., Nohara K.
  Title : , Environmental Health and Preventive Medicine (2024)
• Potential differences in chitin synthesis ability cause different sensitivities to diflubenzuron among three strains of Daphnia magna

  Presenter : KATO K., Okamura K., Hiki K., Kintsu H., Nohara K., Yamagishi T., Nakajima N., Watanabe H., Yamamoto H.
  Title : , Aquatic Toxicology, 243(106071): (2022)
• Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells

  Presenter : Okamura K., Sato M., Suzuki T., Nohara K.
  Title : , Toxicology and Applied Pharmacology, 454: (2022)
• Identification by TCGA database search of five genes that are aberrantly expressed and involved in hepatocellular carcinoma potentially via DNA methylation changes

  Presenter : Matsushita J., Suzuki T., Okamura K., Ichihara G., Nohara K.
  Title : , Environmental Health and Preventive Medicine, 25: (2020)
• Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and F2 offspring via different pathways

  Presenter : Okamura K., Suzuki T., Nohara K.
  Title : , Toxicology and Applied Pharmacology (2020)
• Gestational arsenic exposure and paternal intergenerational epigenetic inheritance.

  Presenter : Nohara K., Suzuki T., Okamura K.
  Title : , Toxicol Appl Pharmacol (2020)
• Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice

  Presenter : Nohara K., Nakabayashi K., Okamura K., Suzuki T., Suzuki S., Hata K.
  Title : , Epigenetics & Chromatin, 13(53): (2020)
• DNA methylation changes involved in the tumor increase in F2 males born to gestationally arsenite-exposed F1 male mice

  Presenter : Okamura K., Nakabayashi K., Kawai T., Suzuki T., Sano T., Hata K., Nohara K.
  Title : , Cancer Science, 110:2629-2642 (2019)
• The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

  Presenter : Matsushita J., Okamura K., Nakabayashi K, Suzuki T., Horibe Y., Kawai T., Sakurai T., Yamashita S., Higami Y., Ichihara G., Hata K., Nohara K.
  Title : , BMC Cancer, 18:317 (2018)
• Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells

  Presenter : Okamura K., Nohara K.
  Title : , Archives of Toxicology, 90(4):793-803 (2016)
• Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring

  Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Michikawa T., Ito T., Shinjo K., Takumi S., Kondo Y., Hata K.
  Title : , Journal of Applied Toxicology, 36(1):105-112 (2015)
• The effect of a methyl-deficient diet on the global DNA methylation and the DNA methylation regulatory pathways

  Presenter : Takumi S., Okamura K., Yanagisawa H., Sano T., Kobayashi Y., Nohara K.
  Title : , Journal of Applied Toxicology, 760:1550-1556 (2014)
• Inorganic arsenic exposure induces E2F-dependent G0/G1 arrest via an increase in retinoblastoma family protein p130 in B-cell lymphoma A20 cells.

  Presenter : Okamura K., Miki D., Nohara K.
  Title : , Genes to Cells, 18(10):839-849 (2013)
• Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic

  Presenter : Nohara K., Tateishi Y., Suzuki T., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Kobori M., Ito T.
  Title : , Toxicological Sciences, 129:293-304 (2012)

• Arsenic Exposure and Reproductive Toxicity

  Presenter : Udagawa O., Okamura K., Suzuki T., Nohara K.
  Title : , Arsenic Contamination in Asia. Current Topics in Environmental Health and Preventive Medicine. Springer, Singapore, 29-42 (2019)
• Tumor-augmenting effects of gestational arsenic exposure on F1 and F2 in mice

  Presenter : Nohara K., Suzuki T., Okamura K., Matsushita J., Takumi S.
  Title : , Genes and Environment, 39(3): (2017)

Research Result (Presentation)

• all
• Research Presentation

• Research Presentation
  Evaluation of blue light exposure from LED lighting on lifespan and sleep in mice

  Presenter : Okamura K., Sato M., Nohara K.
  Name of Society : SOT 65th Annual Meeting (2026)
  Name of Proceedings : Abstracts
• Research Presentation
  Epigenetic Inheritance of Health Effects by Gestational Exposure to Environmental Chemicals

  Presenter : Nohara K., Suzuki T., Okamura K., Tin-Tin-Win-Shwe
  Name of Society : 1st International Conference: Environmental Pollution and Health Impact on Future Generation in Asian countries (EPHIF2023) (2023)
  Name of Proceedings : Abstracts
• Research Presentation
  Arsenite exposure induces premature senescence in fibroblasts and its association of tumorigenesis

  Presenter : Okamura K., Suzuki T., Nohara K.
  Name of Society : SOT 62nd Annual Meeting (2023)
  Name of Proceedings : Abstracts, 3387
• Research Presentation
  Rising global health issue regarding arsenic contamination: gestational arsenic exposure impacts on neuroimmune markers and anxiety in F1 offspring

  Presenter : Chaw Kyi Tha Thu, Soe-Minn Htway, Suzuki T., Okamura K., Nohara K., Tin-Tin-Win-Shwe
  Name of Society : 5th International Conference on Tropical Medicine and Infectious Diseases (2022)
  Name of Proceedings : Abstracts, EP549
• Research Presentation
  Novel DNA methylation changes induced by gestational arsenite exposure in hepatic tumors in F2 mice

  Presenter : Okamura K., Nakabayashi K., Horibe Y., Kawai T., Suzuki T., Hata K., Nohara K.
  Name of Society : The 5th Annual Meeting of the Japan Society for Developmental Origins of Health and Disease (2016)
  Name of Proceedings : Abstracts, 5(1):41
• Research Presentation
  DNA methylation changes in hepatic normal tissues and tumor tissues in gestationally arsenite-exposed F2 mice

  Presenter : Okamura K., Nohara K.
  Name of Society : The 75th Annual Meeting of the Japanese Cancer Association (2016)
  Name of Proceedings : Abstracts, 95
• Research Presentation
  Long-term arsenite exposure induces premature senescence via DNA damage accumulation in mouse B lymphoma cell line A20 cells

  Presenter : Okamura K., Nohara K.
  Name of Society : 44th Myanmar Health Research Congress (2016)
  Name of Proceedings : Abstracts, 85
• Research Presentation
  The Effects of Gestational Arsenite Exposure on the F2 Generation: Role of Epigenetics

  Presenter : Nohara K., Okamura K., Suzuki T., Hatada I, Hata K
  Name of Society : Society of Toxicology 54th Annual Meeting (2015)
  Name of Proceedings : Abstracts, 523
• Research Presentation
  Gestational Arsenic Exposure Affects Gene Expression in the Kidney and Lung in the F1 and F2 Mice

  Presenter : Takumi S, Okamura K., Suzuki T., Hano H, Nohara K., Yanagisawa H
  Name of Society : Society of Toxicology 54th Annual Meeting (2015)
  Name of Proceedings : Abstracts, 422
• Research Presentation
  Maternal Arsenic Exposure of C3H Mice Increases Hepatic Tumor with an Activating Mutation in the Oncogene Ha-ras in the F2 Generation

  Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Ito T., Shinjo K., Kondo Y.
  Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
  Name of Proceedings : Abstracts
• Research Presentation
  Arsenite Exposure-Induced Lymphocytes G0/G1 Arrest Is Attributable to p130 Accumulation via p16 Increase

  Presenter : Okamura K., Nohara K.
  Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
  Name of Proceedings : Abstracts
• Research Presentation
  The Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future Generations

  Presenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
  Name of Society : NIES Arsenic Workshop 2013 (2013)
  Name of Proceedings : Abstracts, 15
• Research Presentation
  Late increases in tumorigenic stress and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic

  Presenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
  Name of Society : Prenatal Programming and Toxicity(PPTOX)? Meeting (2012)
  Name of Proceedings : Abstracts
• Research Presentation
  Late-onset gene expression changes in the livers of male C3H mice maternally exposed to arsenic: Implications for an increase in hepatic tumor incidence

  Presenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
  Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
  Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting

• Epigenetic Inheritance of Health Effects by Gestational Exposure to Environmental Chemicals

  Presenter : Nohara K., Suzuki T., Okamura K., Tin-Tin-Win-Shwe
  Name of Society : 1st International Conference: Environmental Pollution and Health Impact on Future Generation in Asian countries (EPHIF2023) (2023)
  Name of Proceedings : Abstracts
• Novel DNA methylation changes induced by gestational arsenite exposure in hepatic tumors in F2 mice

  Presenter : Okamura K., Nakabayashi K., Horibe Y., Kawai T., Suzuki T., Hata K., Nohara K.
  Name of Society : The 5th Annual Meeting of the Japan Society for Developmental Origins of Health and Disease (2016)
  Name of Proceedings : Abstracts, 5(1):41
• DNA methylation changes in hepatic normal tissues and tumor tissues in gestationally arsenite-exposed F2 mice

  Presenter : Okamura K., Nohara K.
  Name of Society : The 75th Annual Meeting of the Japanese Cancer Association (2016)
  Name of Proceedings : Abstracts, 95
• The Effects of Gestational Arsenite Exposure on the F2 Generation: Role of Epigenetics

  Presenter : Nohara K., Okamura K., Suzuki T., Hatada I, Hata K
  Name of Society : Society of Toxicology 54th Annual Meeting (2015)
  Name of Proceedings : Abstracts, 523
• Arsenite Exposure-Induced Lymphocytes G0/G1 Arrest Is Attributable to p130 Accumulation via p16 Increase

  Presenter : Okamura K., Nohara K.
  Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
  Name of Proceedings : Abstracts
• The Effects of Gestational Inorganic Arsenic Exposure in the Offspring and Future Generations

  Presenter : Nohara K., Suzuki T., Takumi S., Okamura K., Maekawa F.
  Name of Society : NIES Arsenic Workshop 2013 (2013)
  Name of Proceedings : Abstracts, 15
• Evaluation of blue light exposure from LED lighting on lifespan and sleep in mice

  Presenter : Okamura K., Sato M., Nohara K.
  Name of Society : SOT 65th Annual Meeting (2026)
  Name of Proceedings : Abstracts
• Arsenite exposure induces premature senescence in fibroblasts and its association of tumorigenesis

  Presenter : Okamura K., Suzuki T., Nohara K.
  Name of Society : SOT 62nd Annual Meeting (2023)
  Name of Proceedings : Abstracts, 3387
• Rising global health issue regarding arsenic contamination: gestational arsenic exposure impacts on neuroimmune markers and anxiety in F1 offspring

  Presenter : Chaw Kyi Tha Thu, Soe-Minn Htway, Suzuki T., Okamura K., Nohara K., Tin-Tin-Win-Shwe
  Name of Society : 5th International Conference on Tropical Medicine and Infectious Diseases (2022)
  Name of Proceedings : Abstracts, EP549
• Long-term arsenite exposure induces premature senescence via DNA damage accumulation in mouse B lymphoma cell line A20 cells

  Presenter : Okamura K., Nohara K.
  Name of Society : 44th Myanmar Health Research Congress (2016)
  Name of Proceedings : Abstracts, 85
• Gestational Arsenic Exposure Affects Gene Expression in the Kidney and Lung in the F1 and F2 Mice

  Presenter : Takumi S, Okamura K., Suzuki T., Hano H, Nohara K., Yanagisawa H
  Name of Society : Society of Toxicology 54th Annual Meeting (2015)
  Name of Proceedings : Abstracts, 422
• Maternal Arsenic Exposure of C3H Mice Increases Hepatic Tumor with an Activating Mutation in the Oncogene Ha-ras in the F2 Generation

  Presenter : Nohara K., Okamura K., Suzuki T., Murai H., Ito T., Shinjo K., Kondo Y.
  Name of Society : SOCIETY OF TOXICOLOGY 53rd Annual Meeting (2014)
  Name of Proceedings : Abstracts
• Late increases in tumorigenic stress and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic

  Presenter : Nohara K., Suzuki T., Tateishi Y., Okamura K., Murai H., Takumi S., Maekawa F., Nishimura N., Ito T.
  Name of Society : Prenatal Programming and Toxicity(PPTOX)? Meeting (2012)
  Name of Proceedings : Abstracts
• Late-onset gene expression changes in the livers of male C3H mice maternally exposed to arsenic: Implications for an increase in hepatic tumor incidence

  Presenter : Nohara K., Tateishi Y., Suzuki T., Murai H., Takumi S., Okamura K., Maekawa f. , Nishimura N., Ito T.
  Name of Society : SOCIETY OF TOXICOLOGY 51st Annual Meeting (2012)
  Name of Proceedings : Abstracts of SOCIETY OF TOXICOLOGY 51st Annual Meeting

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