ITO Tomohiro

Researcher Name: ITO Tomohiro

Div (Section) name/title: Health and Environmental Risk Division(Health Effect Assessment Section)/Senior Researcher

Research Subject: Studies on the effects of environmental chemicals on immune cells and their mechanisms

Degree(s): Ph.D. (Environmental Science)

Professional Qualification(s): Pharmacy,Biochemistry

Environmental Speciality Field: Environmental toxicology

Keyword(s): Immunology,Dioxin,Cell culture,Gene recombination,Flow cytometry,Molecular biology,Microarray,RNA interference,Dendritic cells

Membership of Academic Society: Japan Society of Endocrine Disrupters Research (JSEDR),The Molecular Biology Society of Japan,The pharmaceutical society of japan

Research Subject

Fiscal Year: 2025
- 27216 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 27364 : Comprehensive Study of the Developmental Neurotoxic Effects of Nanoplastics
- 27381 : A fundamental study for evaluating health impact of environmental factors
- 27393 : Nanoplastic particles: Preparation of standard materials and their potential health hazards
Fiscal Year: 2024
- 26829 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26926 : Comprehensive Study of the Developmental Neurotoxic Effects of Nanoplastics
- 26947 : A fundamental study for evaluating health impact of environmental factors
- 27059 : Nanoplastic particles: Preparation of standard materials and their potential health hazards
Fiscal Year: 2023
- 26420 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26709 : A fundamental study for evaluating health impact of environmental factors
Fiscal Year: 2022
- 25973 : Research project on the health hazard assessment considering the real-life environment and vulnerability
- 26159 : A fundamental study for evaluating health impact of environmental factors
- 26270 : Long-term analysis of greenhouse gases in the polar region with the Siberian tower network
Fiscal Year: 2021
- 25517 : Research on the health hazard assessment considering the real-life environment and vulnerability
- 25625 : A fundamental study for evaluating health impact of environmental factors
Fiscal Year: 2020
- 25099 : Research Program on Health and Environmental Safety
- 25141 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 25142 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 25236 : A Fundamental Study for Evaluating Health Impact of Environmental Factors
- 25324 : Development of neurotoxicity testing with multi-neurodevelopmental processes by using mouse ES cells
Fiscal Year: 2019
- 24696 : Research Program on Health and Environmental Safety
- 24721 : Research Project on Health Impacts of Chemicals on Children and Future Generations
- 24722 : Project to Develop Integrated Approaches to Detecting and Assessment of Multiple and Unknown Chemicals, and Building Environmental Monitoring Networks
- 24832 : Source apportionment of various toxicities by atmospheric organic aerosols
- 24926 : A Fundamental Study for Evaluating Health Impact of Environmental Factors
Fiscal Year: 2018
- 24304 : Research project on health impacts of chemicals on children and future generations
- 24305 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 24355 : Research program on health and environmental safety
- 24386 : Source apportionment of various toxicities by atmospheric organic aerosols
- 24531 : A fundamental study for evaluating health impact of environmental factors
- 24583 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
Fiscal Year: 2017
- 23823 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23824 : Research project on health impacts of chemicals on children and future generations
- 23847 : Research program on health and environmental safety
- 23975 : A fundamental study for evaluating health impact of environmental factors
- 23986 : Effective development of iPS cells into alveolar epithelium by utilization of basement membrane substratum
- 24009 : Source apportionment of various toxicities by atmospheric organic aerosols
- 24107 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
Fiscal Year: 2016
- 23414 : Research program on health and environmental safety
- 23415 : Research project on health impacts of chemicals on children and future generations
- 23416 : Project to develop integrated approaches to detecting and assessment of multiple and unknown chemicals, and building environmental monitoring networks
- 23640 : Development of in vitro hazard testing systems using iPS cells
- 23641 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
- 23659 : A fundamental study for evaluating health impact of environmental factors
- 23680 : Effective development of iPS cells into alveolar epithelium by utilization of basement membrane substratum
- 23684 : Effects of airborne particulates in China on lung cells
Fiscal Year: 2015
- 23018 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 23170 : Development of in vitro hazard testing systems using iPS cells
- 23172 : Detection of chemical substances with epigenetic activity to protect environmental risk by the adverse outcome pathway approach
- 23202 : Effects of airborne particulates in China on lung cells
- 23203 : Study for toxicities of environmental pollutants by using pluripotent stem cells
Fiscal Year: 2014
- 22606 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22894 : Development of in vitro hazard testing systems using iPS cells
- 22895 : Study for toxicities of environmental pollutants by using pluripotent stem cells
- 22958 : Effects of airborne particulates in China on lung cells
Fiscal Year: 2013
- 22190 : Mechanism and evaluation system of the developmental health effects of environmental factors
- 22550 : Study for toxicities of environmental pollutants by using pluripotent stem cells
- 22570 : Health effects of secondary organic aerosols derived from diesel exhaust.
Fiscal Year: 2012
- 21761 : Mechanism and evaluation system of the developmental health effects of environmental factors
Fiscal Year: 2011
- 21319 : Mechanism and evaluation system of the developmental health effects of environmental factors
Fiscal Year: 2010
- 20844 : Effects of environmental chemicals on antigen-presenting cells
- 20921 : Estimating of toxicities of environmental pollutants on hematopoietic stem cells using iPS cells
Fiscal Year: 2009
- 20764 : in vitro evaluation of effects of diesel exhaust particles using iPS-derived cardiomyocytes
- 20765 : Effects of environmental chemicals on antigen-presenting cells
Fiscal Year: 2008
- 20147 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells
Fiscal Year: 2007
- 10650 : Effect of environmental pollutants on the skin immunity by using langerhans cells
- 10677 : Development of evaluation system which can predict the effects of environmental chemicals on hypersensitive subjects with atopy using dendritic cells
Fiscal Year: 2006
- 10050 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
Fiscal Year: 2005
- 9521 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
Fiscal Year: 2004
- 9050 : Studies on the health effects of endocrine disrupters
- 9217 : Identification of causal genes responsible for dioxin-induced immunosuppression using RNAi
- 9272 : Studies on application of toxicogenomics for risk assessment of environmental pollutants
Fiscal Year: 2003
- 8610 : Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment

Research Result (Publication)

all
Original Paper
Other Publications

Original Paper
Whole-tissue distribution analysis for visualization of nanoplastics in the neonatal mouse brain

Presenter : MI Y., Ito T., Tanaka K., Udagawa O., Kakeyama M., Tsutsumi Y., Maekawa F.
Title : , Journal of Hazardous Materials Advances (2026)
Original Paper
Human neurons are susceptible to the internalization of small-sized nanoplastics

Presenter : Ito T., Ikuno Y., Udagawa O., Tanaka K., Kurokawa Y., Kakeyama M., Maekawa F.
Title : , Environmental Toxicology and Pharmacology, 118:104776 (2025)
Original Paper
Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids

Presenter : Katsura M., Urada Y., Nansai H., Kobayashi M., Taguchi A., Ishikawa Y., Ito T., Fukunaga H., Tozawa H., Chikaoka Y., Nakaki R., Echigo A., Kohro T., Sone H., Wada Y.
Title : , Scientific Reports, 13:12888 (2023)
Original Paper
iGEM as a human iPS cell-based global epigenetic modulation detection assay provides throughput characterization of chemicals affecting DNA methylation

Presenter : Otsuka S., Qin X.Y., Wang W., Ito T., Abe K., Fujibuchi W., Nakao Y., Sone H.
Title : , Scientific Reports, 13:6663 (2023)
Original Paper
Source Contributions to Multiple Toxic Potentials of Atmospheric Organic Aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Ramasamy S., Schauer J. J., Fu P., Takahashi Y., Saitoh K., Saito S., Takami A.
Title : , Science of the Total Environment, 773(145614):1-10 (2021)
Original Paper
Epigenetic effects of insecticides on early differentiation of mouse embryonic stem cells

Presenter : Wang W., Ito T., Otsuka S., Nansai H., Abe K., Nakao Y., Ohgane J., Yoneda M., Sone H.
Title : , Toxicology in Vitro, 75:105174 (2021)
Other Publications
Hazard evaluation of air pollution by using the key characteristics approach

Presenter : Sone H., Ito T., Tin-Tin-Win-Shwe, Miki M., Fujitani Y., Nakajima D.
Title : , Earth and Environmental Science, 496:012004 (2020)
Original Paper
Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres

Presenter : Kikegawa M., Qin X.Y., Ito T., Nishikawa H., Nansai H., Sone H.
Title : , International Journal of Molecular Sciences, 21:5564 (2020)
Original Paper
PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

Presenter : He M., Ichinose T, Yoshida S., Ito T., He C., Yoshida Y., Arashidani K., Takano H., Sun G., Shibamoto T.
Title : , Journal of Applied Toxicology, 37(10):1203-1218 (2017)
Original Paper
3D neurosphere system using human stem cells for nanotoxicology studies. Organoids and Mini-Organs

Presenter : Zeng Y., Tin-Tin-Win-Shwe, Ito T., Sone H.
Title : , Organoids and Mini-Organs, Chapter 9, Elsevier (2017)
Original Paper
PM2.5 collected in China causes inflammatory and oxidative stress responses in macrophages through the multiple pathways

Presenter : Bekki K., Ito T., Yoshida Y., He C., Arashidani K., He M., Sun G., Zeng Y., Sone H., Kunugita N., Ichinose T.
Title : , Environmental Toxicology and Pharmacology, 45:362-369 (2016)
Original Paper
Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cells

Presenter : Ito T., Inoue Ken-ichiro, Nishimura N., Takano H.
Title : , Journal of Applied Toxicology, 32(2):142-148 (2012)
Original Paper
Dioxin-induced up-regulation of the active form of vitamin D is the main cause for its inhibitory action on osteoblast activities leading to developmental bone toxicity

Presenter : Nishimura N., Nishimura H, Ito T., Miyata C, Izumi K, Fujimaki H., Matsumura F
Title : , Toxicol.Appl.Pharmacol., 236(3):301-309 (2009)
Original Paper
TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice

Presenter : Ito T., Nohara K., Fujimaki H.
Title : , Toxicol.Lett., 177(1):31-37 (2008)
Organic chemicals adsorbed onto diesel exhaust particles directly alter the differentiation of fetal thymocytes through arylhydrocarbon receptor but not oxidative stress responses

Presenter : Ito T., Nagai H., Lin T.M., Peterson R.E., Tohyama C., Kobayashi T., Nohara K.
Title : , J.Immunotoxicol., 3:21-30 (2006)
Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-induced CYP1A1gene expression profile in lymphocytes from mice,rats,and humans: Most potent induction in humans

Presenter : Nohara K., Ao K., Miyamoto Y., Ito T., Suzuki T., Toyoshiba H., Tohyama C.
Title : , Toxicology, 225:204-213 (2006)
Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes

Presenter : Nohara K., Pan X., Tsukumo S., Hida A., Ito T., Nagai H., Inouye K., Motohashi H., Yamamoto M., Fujii-Kuriyama Y., Tohyama C.
Title : , J.Immunol., 174:2770-2777 (2005)
T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)

Presenter : Inouye K., Pan X., Imai N., Ito T., Takei T., Tohyama C., Nohara K.
Title : , Chemosphere, 60:907-913 (2005)
A constitutively active arylhydrocarbon receptor induces growth inhibition of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest

Presenter : Ito T., Tsukumo S., Suzuki N., Motohashi H., Yamamto M., Fujii-Kuriyama Y., Mimura J., Lin T.M., Peterson R.E., Tohyama C., Nohara K.
Title : , J.Biol.Chem., 279(24):25204-25210 (2004)
Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin(OVA)-immunized mice

Presenter : Pan X., Inouye K., Ito T., Nagai H., Takeuchi Y., Miyabara Y., Tohyama C., Nohara K.
Title : , Toxicology, 204:51-60 (2004)
Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on the high-affinity antibody response in C57BL/6 mice

Presenter : Inouye K., Ito T., Fujimaki H., Takahashi Y., Takemori T., Pan X., Tohyama C., Nohara K.
Title : , Toxicol.Sci., 74:315-324 (2003)
Mechanism of TCDD-induced suppression of antibody production: effect on T cell-derived cytokine production in the primary immune reaction of mice

Presenter : Ito T., Inouye K., Fujimaki H., Tohyama C., Nohara K.
Title : , Toxicol.Sci., 70:46-54 (2002)

Whole-tissue distribution analysis for visualization of nanoplastics in the neonatal mouse brain

Presenter : MI Y., Ito T., Tanaka K., Udagawa O., Kakeyama M., Tsutsumi Y., Maekawa F.
Title : , Journal of Hazardous Materials Advances (2026)
Human neurons are susceptible to the internalization of small-sized nanoplastics

Presenter : Ito T., Ikuno Y., Udagawa O., Tanaka K., Kurokawa Y., Kakeyama M., Maekawa F.
Title : , Environmental Toxicology and Pharmacology, 118:104776 (2025)
Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids

Presenter : Katsura M., Urada Y., Nansai H., Kobayashi M., Taguchi A., Ishikawa Y., Ito T., Fukunaga H., Tozawa H., Chikaoka Y., Nakaki R., Echigo A., Kohro T., Sone H., Wada Y.
Title : , Scientific Reports, 13:12888 (2023)
iGEM as a human iPS cell-based global epigenetic modulation detection assay provides throughput characterization of chemicals affecting DNA methylation

Presenter : Otsuka S., Qin X.Y., Wang W., Ito T., Abe K., Fujibuchi W., Nakao Y., Sone H.
Title : , Scientific Reports, 13:6663 (2023)
Source Contributions to Multiple Toxic Potentials of Atmospheric Organic Aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Ramasamy S., Schauer J. J., Fu P., Takahashi Y., Saitoh K., Saito S., Takami A.
Title : , Science of the Total Environment, 773(145614):1-10 (2021)
Epigenetic effects of insecticides on early differentiation of mouse embryonic stem cells

Presenter : Wang W., Ito T., Otsuka S., Nansai H., Abe K., Nakao Y., Ohgane J., Yoneda M., Sone H.
Title : , Toxicology in Vitro, 75:105174 (2021)
Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres

Presenter : Kikegawa M., Qin X.Y., Ito T., Nishikawa H., Nansai H., Sone H.
Title : , International Journal of Molecular Sciences, 21:5564 (2020)
PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

Presenter : He M., Ichinose T, Yoshida S., Ito T., He C., Yoshida Y., Arashidani K., Takano H., Sun G., Shibamoto T.
Title : , Journal of Applied Toxicology, 37(10):1203-1218 (2017)
3D neurosphere system using human stem cells for nanotoxicology studies. Organoids and Mini-Organs

Presenter : Zeng Y., Tin-Tin-Win-Shwe, Ito T., Sone H.
Title : , Organoids and Mini-Organs, Chapter 9, Elsevier (2017)
PM2.5 collected in China causes inflammatory and oxidative stress responses in macrophages through the multiple pathways

Presenter : Bekki K., Ito T., Yoshida Y., He C., Arashidani K., He M., Sun G., Zeng Y., Sone H., Kunugita N., Ichinose T.
Title : , Environmental Toxicology and Pharmacology, 45:362-369 (2016)
Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cells

Presenter : Ito T., Inoue Ken-ichiro, Nishimura N., Takano H.
Title : , Journal of Applied Toxicology, 32(2):142-148 (2012)
Dioxin-induced up-regulation of the active form of vitamin D is the main cause for its inhibitory action on osteoblast activities leading to developmental bone toxicity

Presenter : Nishimura N., Nishimura H, Ito T., Miyata C, Izumi K, Fujimaki H., Matsumura F
Title : , Toxicol.Appl.Pharmacol., 236(3):301-309 (2009)
TCDD exposure exacerbates atopic dermatitis-related inflammation in NC/Nga mice

Presenter : Ito T., Nohara K., Fujimaki H.
Title : , Toxicol.Lett., 177(1):31-37 (2008)

Hazard evaluation of air pollution by using the key characteristics approach

Presenter : Sone H., Ito T., Tin-Tin-Win-Shwe, Miki M., Fujitani Y., Nakajima D.
Title : , Earth and Environmental Science, 496:012004 (2020)

Research Result (Presentation)

all
Research Presentation
Research Lecture

Research Presentation
Effects of Gestational Diphenylarsinic Acid Exposure on Birth Outcomes and Nanoplastic Biodistribution in the Neonatal Brain

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : Federation of European Neuroscience Societies (FENS) Forum 2026 (2026)
Name of Proceedings : -
Research Presentation
Gestational exposure to diphenylarsinic acid alters birth outcomes and influences nanoplastic brain uptake in neonatal mice

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : International Symposium for the 20th Anniversary of the JSBN (2026)
Name of Proceedings : Abstracts, 13
Research Presentation
Size-Dependent Brain Uptake and Regional Localization of Nanoplastics in Neonatal Mice Following Oral Exposure

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 103rd Annual Meeting of The Physiological Society of Japan (2026)
Name of Proceedings : Abstracts, 126
Research Presentation
Neonatal Brain Exposure to Nanoplastics via Oral Route: Size-Dependent Uptake and Regional Localization

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Conference Prpgram, 52
Research Presentation
Investigation of hazardous effects by nanoplastic particles on intracellular signaling dynamics and respiratory functions

Presenter : HARADA K., Udagawa O., Ikuno Y., Tanaka K., Ito T., Maekawa F., Kitaguchi T., Tsuboi T., Fujitani Y.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Abstracts, 118
Research Presentation
Accumulation of nanoplastics in the neonatal mouse brain visualized by imaging

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 96th Annual Meeting of the Zoological Society of Japan (2025)
Name of Proceedings : Abstracts, 27
Research Presentation
Nanoplastics and the Developing Brain: Early-Life Oral Exposure and Size- Dependent Accumulation

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 27th Research Presentation Meeting of the Japan Society of Endocrine Disruptors Research (2025)
Name of Proceedings : Abstracts
Research Presentation
Analysis of effects of nanoplastic particles on human neurons

Presenter : Ito T., Maekawa F.
Name of Society : ISTA21 (21st International Symposium on Toxicity Assessment) (2024)
Name of Proceedings : Abstracts, 66
Research Presentation
Driver Gene Detection through Bayesian Network Integration of Cellular Phonotypes and Expression Profiles

Presenter : Sone H., Qin X.Y., Ito T., Kikegawa M.
Name of Society : 2022年日本バイオインフォマティクス学会年会・第11回生命医薬情報学連合大会(IIBMP2022) (2022)
Name of Proceedings : 同予稿集
Research Presentation
Source apportionment of multiple toxic potentials of atmospheric organic aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Ramasamy S., Schauer J. J., Fu P., Takahashi Y., Saitoh K., Saito S., Takami A.
Name of Society : European Aerosol Conference - EAC 2021 (2021)
Name of Proceedings : Abstracts, (OP P1 - 235)
Research Presentation
Hazard evaluation of air pollution by using the key characteristics approach

Presenter : Sone H., Miki M., Ito T., Tin-Tin-Win-Shwe, Fujitani Y., Nakajima D.
Name of Society : 5th NIES International Forum (2020)
Name of Proceedings : Abstract, 70
Research Presentation
Novel Method for Source Apportionment of Toxicity of Atmospheric Organic Aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Takami A.
Name of Society : 5th International Forum on Sustainable Future in Asia / 5th NIES International Forum (2020)
Name of Proceedings : Abstracts, 79
Research Presentation
New approach for source apportionment of toxicity by atmospheric organic aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Takami A.
Name of Society : 37th AAAR (American Association for Aerosol Research) Annual Conference (2019)
Name of Proceedings : Abstracts, (2AD.5)
Research Lecture
Effect-based Detection of Organic Chemicals in PM2.5 for Their Risk Management

Presenter : Suzuki G., Michinaka C., Nakajima D., Furuyama A., Ito T., Sato K., Kondo Y., Fujitani Y., Takahashi Y., Yagishita M., Ramasamy S., Takami A., Fushimi A.
Name of Society : 47th Myanmar Health Research Congress (2019)
Name of Proceedings : Abstracts, 21-25
Research Presentation
Dioxin-induced up-regulation of vitamin D is the main cause for its inhibitory action on osteoblast activities, leading to developmental bone toxicity

Presenter : Nishimura N., Nishimura H., Ito T., Fujimaki H., Matsumura F.
Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
Name of Proceedings : Abstracts, 158
Research Presentation
Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on born development in mouse pups

Presenter : Nishimura N., Ito T., Izumi K., Nishimura H., Fujimaki H.
Name of Society : Eurotox 2008 (2008)
Name of Proceedings : Toxicol.Lett., 180S:S194
Research Presentation
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin bone mineralization the growing mouse

Presenter : , , Ito T.
Name of Society : SOT 2008 (2008)
Name of Proceedings : Abstracts
Research Presentation
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on bone mineralization, vitamin D metabolism and calcium(Ca) homeostasis in the growing mouse

Presenter : Nishimura N., Ito T., Fujimaki H., Izumi K., Nishimura H.
Name of Society : 5th SETAC World Congr. (2008)
Name of Proceedings : Abstracts
Research Presentation
Defect of mineralization as a possible cause of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced bone toxicity in early postnatal development in mice

Presenter : Nishimura N., Ito T., Fujimaki H., Nishimura H.
Name of Society : 28th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2008 (2008)
Name of Proceedings : Organohalogen Compd., 70:1924-1927
Research Presentation
Phthalate esters modulate the differentiation of mouse peripheral blood mononuclear cells-derived dendritic cells

Presenter : Ito T., Inoue Ken-ichiro, Koike E., Yanagisawa R., Nishimura N., Takano H.
Name of Society : 45th Congr.Eur.Soc.Toxicol. (2008)
Name of Proceedings : Toxicol.Lett., 180S:S117
Research Presentation
Up-regulation of 25-hydroxyvitamin D3 1α-hydroxylase and disruption of calcium metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing mouse kidney

Presenter : , , Ito T.
Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007 (2007)
Name of Proceedings : Organohalogen Compd., 69
Research Presentation
Changes of gene expression involved in vitamin D metabolism and transcellular CA2+ transport by 2,3,7,8-tetrachlorodibenzo-p-dioxin in developing mouse kidney

Presenter : , , Ito T.
Name of Society : Int.Congr.Toxicol.(Poster Session) (2007)
Name of Proceedings : Abstracts
Research Presentation
Search for genes involved in the growth inhibition of Jurkat T cells by a constitutively active arylhydrocarbon receptor

Presenter : Ito T.
Name of Society : 20th IUBMB Int.Congr.Biochem.Mol.Biol.11th FAOBMB Congr.(Poster Session) (2006)
Name of Proceedings : Abstracts
Research Presentation
Distinctive gene expression patterns in thymuses exposed to atrophy-inducing chemicals

Presenter : , Ito T.
Name of Society : SOT Annu.Meet.2006(Poster Session) (2006)
Name of Proceedings : Toxicologist, 90
Research Presentation
Comparison of the TCDD-induced CYP1A1 gene expression profile in lymphocytes from mice,rats and humans

Presenter : , Ito T.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Toxicologist, 84
Research Presentation
Gene expression changes in fetal thymus exposed to organic compounds extracted from diesel exhaust particles.

Presenter : Tohyama C., Ito T.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Toxicologist, 84
Research Presentation
Activation of arylhydrocarbon receptor(AhR) in T lineage cells inhibits cellular growth.

Presenter : , Ito T.
Name of Society : 24th Int.Symp.Halogenat.Environ.Org.Pollut.POPs; DIOXIN 2004 (2004)
Name of Proceedings : Organohalogen Compd., 66
Research Presentation
Thymocyte alterations in CD2-driven constitutively active arylhydrocarbon receptor(AHR) transgenic mice

Presenter : , Ito T.
Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
Name of Proceedings : Toxicologist, 72:362
Research Presentation
A constitutively active aryl hydrocarbon receptor induces growth inhibition by cell cycle arrest and apoptosis in jurkat T cells

Presenter : , Ito T.
Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
Name of Proceedings : Toxicologist, 72:367
The effects of TCDD on germinal center formation in the spleen of C57BL/6 mice

Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
Name of Proceedings : Toxicologist, 61
Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on Th2-derived cytokine production in primary immune reaction of mice

Presenter : Nohara K., Ito T., Inouye K., Fujimaki H., Tohyama C.
Name of Society : Soc.Toxicol.: 41st Annu.Meet. (2002)
Name of Proceedings : Toxicologist, 61
Alteration of B cell development in the spleen of C57B1/6 mice by TCDD treatment

Presenter : Inouye K., Ito T., Fujimaki H., Tohyama C., Nohara K.
Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
Name of Proceedings : Program & Abstracts
Mechanisms for 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)- induced suppression of antigen-specific antibody production

Presenter : Ito T., Inouye K., Fujimaki H., Tohyama C., Nohara K.
Name of Society : 4th Annu.Meet.Jpn.Soc.Endocr.Disrupters Res. (2001)
Name of Proceedings : Program & Abstracts

Size-Dependent Brain Uptake and Regional Localization of Nanoplastics in Neonatal Mice Following Oral Exposure

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 103rd Annual Meeting of The Physiological Society of Japan (2026)
Name of Proceedings : Abstracts, 126
Neonatal Brain Exposure to Nanoplastics via Oral Route: Size-Dependent Uptake and Regional Localization

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Conference Prpgram, 52
Accumulation of nanoplastics in the neonatal mouse brain visualized by imaging

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 96th Annual Meeting of the Zoological Society of Japan (2025)
Name of Proceedings : Abstracts, 27
Nanoplastics and the Developing Brain: Early-Life Oral Exposure and Size- Dependent Accumulation

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : The 27th Research Presentation Meeting of the Japan Society of Endocrine Disruptors Research (2025)
Name of Proceedings : Abstracts
Analysis of effects of nanoplastic particles on human neurons

Presenter : Ito T., Maekawa F.
Name of Society : ISTA21 (21st International Symposium on Toxicity Assessment) (2024)
Name of Proceedings : Abstracts, 66
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin bone mineralization the growing mouse

Presenter : , , Ito T.
Name of Society : SOT 2008 (2008)
Name of Proceedings : Abstracts
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on bone mineralization, vitamin D metabolism and calcium(Ca) homeostasis in the growing mouse

Presenter : Nishimura N., Ito T., Fujimaki H., Izumi K., Nishimura H.
Name of Society : 5th SETAC World Congr. (2008)
Name of Proceedings : Abstracts
Up-regulation of 25-hydroxyvitamin D3 1α-hydroxylase and disruption of calcium metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing mouse kidney

Presenter : , , Ito T.
Name of Society : 27th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2007 (2007)
Name of Proceedings : Organohalogen Compd., 69
Changes of gene expression involved in vitamin D metabolism and transcellular CA2+ transport by 2,3,7,8-tetrachlorodibenzo-p-dioxin in developing mouse kidney

Presenter : , , Ito T.
Name of Society : Int.Congr.Toxicol.(Poster Session) (2007)
Name of Proceedings : Abstracts
Search for genes involved in the growth inhibition of Jurkat T cells by a constitutively active arylhydrocarbon receptor

Presenter : Ito T.
Name of Society : 20th IUBMB Int.Congr.Biochem.Mol.Biol.11th FAOBMB Congr.(Poster Session) (2006)
Name of Proceedings : Abstracts
Distinctive gene expression patterns in thymuses exposed to atrophy-inducing chemicals

Presenter : , Ito T.
Name of Society : SOT Annu.Meet.2006(Poster Session) (2006)
Name of Proceedings : Toxicologist, 90
Comparison of the TCDD-induced CYP1A1 gene expression profile in lymphocytes from mice,rats and humans

Presenter : , Ito T.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Toxicologist, 84
Gene expression changes in fetal thymus exposed to organic compounds extracted from diesel exhaust particles.

Presenter : Tohyama C., Ito T.
Name of Society : Soc.Toxicol.44th Annu.Meet. (2005)
Name of Proceedings : Toxicologist, 84
Activation of arylhydrocarbon receptor(AhR) in T lineage cells inhibits cellular growth.

Presenter : , Ito T.
Name of Society : 24th Int.Symp.Halogenat.Environ.Org.Pollut.POPs; DIOXIN 2004 (2004)
Name of Proceedings : Organohalogen Compd., 66
Thymocyte alterations in CD2-driven constitutively active arylhydrocarbon receptor(AHR) transgenic mice

Presenter : , Ito T.
Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
Name of Proceedings : Toxicologist, 72:362
A constitutively active aryl hydrocarbon receptor induces growth inhibition by cell cycle arrest and apoptosis in jurkat T cells

Presenter : , Ito T.
Name of Society : Soc.Toxicol.42nd Annu.Meet. (2003)
Name of Proceedings : Toxicologist, 72:367
Effects of Gestational Diphenylarsinic Acid Exposure on Birth Outcomes and Nanoplastic Biodistribution in the Neonatal Brain

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : Federation of European Neuroscience Societies (FENS) Forum 2026 (2026)
Name of Proceedings : -
Gestational exposure to diphenylarsinic acid alters birth outcomes and influences nanoplastic brain uptake in neonatal mice

Presenter : MI Y., Ito T., Tanaka K., Maekawa F.
Name of Society : International Symposium for the 20th Anniversary of the JSBN (2026)
Name of Proceedings : Abstracts, 13
Investigation of hazardous effects by nanoplastic particles on intracellular signaling dynamics and respiratory functions

Presenter : HARADA K., Udagawa O., Ikuno Y., Tanaka K., Ito T., Maekawa F., Kitaguchi T., Tsuboi T., Fujitani Y.
Name of Society : Microplastics Exposure and Human Health Conference (2026)
Name of Proceedings : Abstracts, 118
Driver Gene Detection through Bayesian Network Integration of Cellular Phonotypes and Expression Profiles

Presenter : Sone H., Qin X.Y., Ito T., Kikegawa M.
Name of Society : 2022年日本バイオインフォマティクス学会年会・第11回生命医薬情報学連合大会(IIBMP2022) (2022)
Name of Proceedings : 同予稿集
Source apportionment of multiple toxic potentials of atmospheric organic aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Ramasamy S., Schauer J. J., Fu P., Takahashi Y., Saitoh K., Saito S., Takami A.
Name of Society : European Aerosol Conference - EAC 2021 (2021)
Name of Proceedings : Abstracts, (OP P1 - 235)
Hazard evaluation of air pollution by using the key characteristics approach

Presenter : Sone H., Miki M., Ito T., Tin-Tin-Win-Shwe, Fujitani Y., Nakajima D.
Name of Society : 5th NIES International Forum (2020)
Name of Proceedings : Abstract, 70
Novel Method for Source Apportionment of Toxicity of Atmospheric Organic Aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Yoshino A., Takami A.
Name of Society : 5th International Forum on Sustainable Future in Asia / 5th NIES International Forum (2020)
Name of Proceedings : Abstracts, 79
New approach for source apportionment of toxicity by atmospheric organic aerosols

Presenter : Fushimi A., Nakajima D., Furuyama A., Suzuki G., Ito T., Sato K., Fujitani Y., Kondo Y., Takami A.
Name of Society : 37th AAAR (American Association for Aerosol Research) Annual Conference (2019)
Name of Proceedings : Abstracts, (2AD.5)
Dioxin-induced up-regulation of vitamin D is the main cause for its inhibitory action on osteoblast activities, leading to developmental bone toxicity

Presenter : Nishimura N., Nishimura H., Ito T., Fujimaki H., Matsumura F.
Name of Society : HORIBA/CDBIM Symp. -21st Century Adv.Mol.Toxicol.Environ.Chem.Pathog.Dis.- (2009)
Name of Proceedings : Abstracts, 158
Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on born development in mouse pups

Presenter : Nishimura N., Ito T., Izumi K., Nishimura H., Fujimaki H.
Name of Society : Eurotox 2008 (2008)
Name of Proceedings : Toxicol.Lett., 180S:S194
Defect of mineralization as a possible cause of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced bone toxicity in early postnatal development in mice

Presenter : Nishimura N., Ito T., Fujimaki H., Nishimura H.
Name of Society : 28th Int.Symp.Halogenat.Persistent Org.Pollut.-DIOXIN 2008 (2008)
Name of Proceedings : Organohalogen Compd., 70:1924-1927
Phthalate esters modulate the differentiation of mouse peripheral blood mononuclear cells-derived dendritic cells

Presenter : Ito T., Inoue Ken-ichiro, Koike E., Yanagisawa R., Nishimura N., Takano H.
Name of Society : 45th Congr.Eur.Soc.Toxicol. (2008)
Name of Proceedings : Toxicol.Lett., 180S:S117

Effect-based Detection of Organic Chemicals in PM2.5 for Their Risk Management

Presenter : Suzuki G., Michinaka C., Nakajima D., Furuyama A., Ito T., Sato K., Kondo Y., Fujitani Y., Takahashi Y., Yagishita M., Ramasamy S., Takami A., Fushimi A.
Name of Society : 47th Myanmar Health Research Congress (2019)
Name of Proceedings : Abstracts, 21-25

ITO Tomohiro

About