程 久美子

論文

• Progress in siRNA nucleic acid therapeutics and challenges in their application to cancer treatment.

  Kumiko Ui-Tei

  Japanese journal of clinical oncology 2026年7月3日 筆頭著者責任著者
• Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.

  Maho Katsuyama, Taiki Matsubayashi, Yang Ying, Su Su Lei Mon, Takayuki Kuroda, Kie Yoshida-Tanaka, Rintaro Iwata Hara, Takeshi Yamada, Kumiko Ui-Tei, Kotaro Yoshioka

  RSC chemical biology 7(5) 851-861 2026年5月13日
• Rational Design of a Multivalent RNA Combining Structural Motifs Tailored to Multiple Domains of Fused in Sarcoma for Potent Inhibition of Aggregation.

  Nobuaki Kuroiwa, Fumika Sakaue, Motoki Miura, Ayano Go, Ryo Iwase, Rintaro Iwata Hara, Nobuo Sanjo, Kumiko Ui-Tei, Takanori Yokota

  Chembiochem : a European journal of chemical biology 27(8) e202500568 2026年4月28日
• A Period1 inducer specifically advances circadian clock in mice

  Yoshifumi Takahata, Yuki Kasashima, Takuya Yoshioka, Shusei Yashiki, Justina Kulikauskaite, Tomoaki Matsuura, Yuki Ohba, Hideaki Hasegawa, Naoki Yuri, Nagisa Iwai …

  Proceedings of the National Academy of Sciences 123(4) e2509943123 2026年1月23日
• SNPD-siKRAS: siRNA specifically inhibits KRAS with a single-nucleotide mutation

  Yoshiaki Kobayashi, Yoshimasa Asano, Atsushi Sato, Hiroaki Taniguchi, Kumiko Ui-Tei

  bioRxiv The preprint server for biology 2025年9月20日 最終著者責任著者
• An siRMSD parameter of structural distortion induced by chemical modification is predictive of the off-target effect of siRNA

  Seongjin An, Kohei Nomura, Yoshiaki Kobayashi, Yasuaki Kimura, Hiroshi Abe, Kumiko Ui-Tei

  Molecular Therapy Nucleic Acids 36(4) 102693-102693 2025年9月 査読有り責任著者
• TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation.

  Koji Onomoto, Monami Sakai, Miyu Watanabe, Akira Fukao, Yurika Sakamura, Mai Miyao, Takumi Tomohiro, Akio Yamashita, Toshinobu Fujiwara, Tomoko Takahashi …

  Scientific reports 15(1) 20678-20678 2025年7月1日 査読有り
• siRMSD: A Structural Parameter to Reduce Sequence-Dependent Off-Target Effects for siRNA Design with Chemical Modifications.

  Seongjin An, Kumiko Ui-Tei

  Methods in Molecular Biology (Clifton, N.J.) 2965 467-477 2025年 最終著者責任著者
• A microRNA is the effector gene of a classic evolutionary hotspot locus.

  Shen Tian, Yoshimasa Asano, Tirtha Das Banerjee, Shinya Komata, Jocelyn Liang Qi Wee, Abigail Lamb, Yehan Wang, Suriya Narayanan Murugesan, Haruhiko Fujiwara, Kumiko Ui-Tei …

  Science (New York, N.Y.) 386(6726) 1135-1141 2024年12月6日 査読有り
• Synthesis of 2′-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs

  Kohei Nomura, Seongjin An, Yoshiaki Kobayashi, Jiro Kondo, Ting Shi, Hirotaka Murase, Kosuke Nakamoto, Yasuaki Kimura, Naoko Abe, Kumiko Ui-Tei …

  Nucleic Acids Research 52(18) 10754-10774 2024年9月5日 査読有り
• TRBP regulates poly(I:C)-mediated apoptotic pathway by modulating miRNA biogenesis

  Shota Azuma, Yuko Nakano, Tomoko Takahashi, Koji Onomoto, Takeshi Haraguchi, Yutaka Suzuki, Hideo Iba, Mitsutoshi Yoneyama, Yoshimasa Asano, Kumiko Ui-Tei

  bioRxiv The preprint server for biology 2024年5月14日 最終著者責任著者
• Caspase-mediated processing of TRBP regulates apoptosis during viral infection

  Keiko Shibata, Harune Moriizumi, Koji Onomoto, Yuka Kaneko, Takuya Miyakawa, Shuhei Zenno, Masaru Tanokura, Mitsutoshi Yoneyama, Tomoko Takahashi, Kumiko Ui-Tei

  Nucleic Acids Research 52(9) 5209-5225 2024年4月19日 査読有り最終著者責任著者
• A micro-RNA is the effector gene of a classic evolutionary hotspot locus.

  Shen Tian, Yoshimasa Asano, Tirtha Das Banerjee, Jocelyn Liang Qi Wee, Abigail Lamb, Yehan Wang, Suriya Narayanan Murugesan, Kumiko Ui-Tei, Patricia J Wittkopp, Antónia Monteiro

  bioRxiv : the preprint server for biology 2024年4月18日
• SNPD-CRISPR: Single Nucleotide Polymorphism-Distinguishable Repression or Enhancement of a Target Gene Expression by CRISPR System

  Shohei Maruyama, Takashi Kusakabe, Xinyi Zou, Yoshiaki Kobayashi, Yoshimasa Asano, Qingbo S. Wang, Kumiko Ui-Tei

  Methods in Molecular Biology 2637 49-62 2023年2月12日 最終著者責任著者
• Utilizing Large Functional and Population Genomics Resources for CRISPR/Cas Perturbation Experiment Design

  Qingbo S. Wang, Kumiko Ui-Tei

  Methods in Molecular Biology 2637 63-73 2023年2月12日 最終著者責任著者
• siRNAが働く仕組みと医薬品としての研究開発の現状

  小林芳明, 浅野吉政, 程久美子

  循環器内科 93(3) 1-9 2023年 査読有り責任著者
• A 2'-modified uridine analog, 2'-O-(methylthiomethoxy)methyl uridine, for siRNA applications

  Fangjie L, An S, Kobayashi Y, Nomura K, Baba R, Abe N, Hiraoka H, Hashiya F, Shu Z, Ui-Tei K …

  Bioorganic & Medicinal Chemistry Letters 128939-128939 2022年8月 査読有り
• Knockdown of 15-bp Deletion-Type v-raf Murine Sarcoma Viral Oncogene Homolog B1 mRNA in Pancreatic Ductal Adenocarcinoma Cells Repressed Cell Growth In Vitro and Tumor Volume In Vivo

  Jiaxuan Song, Yoshiaki Kobayashi, Yoshimasa Asano, Atsushi Sato, Hiroaki Taniguchi, Kumiko Ui-Tei

  Cancers 14(13) 3162-3162 2022年6月28日 査読有り最終著者責任著者
• The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects

  Yoshiaki Kobayashi, Shen Tian, Kumiko Ui-Tei

  Genes 13(2) 319-319 2022年2月9日 査読有り最終著者責任著者
• siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2′-OMe Modifications

  Yoshiaki Kobayashi, Daiki Fukuhara, Dai Akase, Misako Aida, Kumiko Ui-Tei

  ACS Omega 7(2) 2398-2410 2022年1月4日 査読有り最終著者責任著者