越智 拓海

論文

• Bee larvae ameliorate andropause-like symptoms via a hormone-independent, antioxidant mechanism

  Takashi Ito, Nobuaki Okumura, Takumi Oti, Hirotaka Sakamoto

  Frontiers in Physiology 17 1850114 2026年5月29日 査読有り
• Oxytocin Neuropharmacology: From Brain to Sperm.

  Hirotaka Sakamoto, Chica Enomoto, Takumi Oti

  Current neuropharmacology 2026年5月21日 査読有り
• Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol‐facing catalytic domain in primate oxytocin neurons

  Tatsuki Miyamoto, Akari Matsushima, Akito Otubo, Chihong Song, Kazuyoshi Murata, Takumi Oti, Hirotaka Sakamoto

  Journal of Neuroendocrinology 2026年4月 査読有り
• Dual-action intranasal oxytocin enhances both male sexual performance and fertility in rats

  Chica Enomoto, Takumi Oti, Takahiro Yamanaka, Masayuki Shimada, Hirotaka Sakamoto

  The Journal of Sexual Medicine 22(11) 1923-1925 2025年9月19日 査読有り責任著者
• Neuropeptidergic control circuits in the spinal cord for male sexual behaviour: Oxytocin–gastrin‐releasing peptide systems

  Takumi Oti, Hirotaka Sakamoto

  Journal of Neuroendocrinology 35(9) 2023年7月29日 査読有り招待有り筆頭著者
• Characterization of the expression of gastrin‐releasing peptide and its receptor in the trigeminal and spinal somatosensory systems of Japanese macaque monkeys: Insight into humans

  Keiko Takanami, Takumi Oti, Yasuhisa Kobayashi, Koki Hasegawa, Takashi Ito, Naoaki Tsutsui, Yasumasa Ueda, Earl Carstens, Tatsuya Sakamoto, Hirotaka Sakamoto

  Journal of Comparative Neurology 2022年6月10日 査読有り
• The gastrin-releasing peptide/bombesin system revisited by a reverse-evolutionary study considering Xenopus

  Asuka Hirooka, Mayuko Hamada, Daiki Fujiyama, Keiko Takanami, Yasuhisa Kobayashi, Takumi Oti, Yukitoshi Katayama, Tatsuya Sakamoto, Hirotaka Sakamoto

  Scientific Reports 11(1) 2021年12月 査読有り
• Sexual Experience Induces the Expression of Gastrin-Releasing Peptide and Oxytocin Receptors in the Spinal Ejaculation Generator in Rats

  Takumi Oti, Ryota Ueda, Ryoko Kumagai, Junta Nagafuchi, Takashi Ito, Tatsuya Sakamoto, Yasuhiko Kondo, Hirotaka Sakamoto

  International Journal of Molecular Sciences 22(19) 10362-10362 2021年9月26日 査読有り筆頭著者責任著者
• Immunoelectron Microscopic Characterization of Vasopressin-Producing Neurons in the Hypothalamo-Pituitary Axis of Non-Human Primates by Use of Formaldehyde-Fixed Tissues Stored at –25 °C for Several Years

  Akito Otubo, Sho Maejima, Takumi Oti, Keita Satoh, Yasumasa Ueda, John F. Morris, Tatsuya Sakamoto, Hirotaka Sakamoto

  International Journal of Molecular Sciences 22(17) 9180-9180 2021年8月25日 査読有り
• In Vivo Electrophysiology of Peptidergic Neurons in Deep Layers of the Lumbar Spinal Cord after Optogenetic Stimulation of Hypothalamic Paraventricular Oxytocin Neurons in Rats

  Daisuke Uta, Takumi Oti, Tatsuya Sakamoto, Hirotaka Sakamoto

  International Journal of Molecular Sciences 22(7) 3400-3400 2021年3月26日 査読有り招待有り筆頭著者
• Systemic effects of oxytocin on male sexual activity via the spinal ejaculation generator in rats

  Takumi Oti, Tatsuya Sakamoto, Hirotaka Sakamoto

  Communicative & Integrative Biology 14(1) 55-60 2021年1月1日 査読有り筆頭著者
• Oxytocin influences male sexual activity via non-synaptic axonal release in the spinal cord

  Takumi Oti, Keita Satoh, Daisuke Uta, Junta Nagafuchi, Sayaka Tateishi, Ryota Ueda, Keiko Takanami, Larry J. Young, Antony Galione, John F. Morris …

  Current Biology 31(1) 103-114 2021年1月 査読有り筆頭著者
• Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity

  Kohro Y, Matsuda T, Yoshihara K, Kohno K, Koga K, Katsuragi R, Oka T, Tashima R, Muneta S, Yamane T …

  Nature Neuroscience 23(11) 1376-1387 2020年10月 査読有り
• Variation of pro-vasopressin processing in parvocellular and magnocellular neurons in the paraventricular nucleus of the hypothalamus: Evidence from the vasopressin-related glycopeptide copeptin

  Kawakami N, Otubo A, Maejima S, Talukder AH, Satoh K, Oti T, Takanami K, Ueda Y, Itoi K, Morris JF …

  Journal of comparative neurology 2020年9月 査読有り
• Early-life exposure to Tris(1,3-dichloroisopropyl) phosphate induces dose-dependent suppression of sexual behavior in male rats.

  Manami Kamishima, Tatsuya Hattori, Go Suzuki, Hidenori Matsukami, Chiaki Komine, Yasuyuki Horii, Gen Watanabe, Takumi Oti, Hirotaka Sakamoto, Tomoko Soga …

  Journal of applied toxicology : JAT 38(5) 649-655 2018年5月 査読有り
• Effects of Sex Steroids on the Spinal Gastrin-Releasing Peptide System Controlling Male Sexual Function in Rats.

  Takumi Oti, Keiko Takanami, Saya Ito, Takashi Ueda, Ken Ichi Matsuda, Mitsuhiro Kawata, Jintetsu Soh, Osamu Ukimura, Tatsuya Sakamoto, Hirotaka Sakamoto

  Endocrinology 159(4) 1886-1896 2018年4月 査読有り筆頭著者
• A sexually dimorphic peptidergic system in the lower spinal cord controlling penile function in non-human primates

  T. Ito, T. Oti, K. Takanami, K. Satoh, Y. Ueda, T. Sakamoto, H. Sakamoto

  Spinal Cord 56(1) 57-62 2018年 査読有り筆頭著者
• Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus)

  Kei Tamura, Yasuhisa Kobayashi, Asuka Hirooka, Keiko Takanami, Takumi Oti, Takamichi Jogahara, Sen-ichi Oda, Tatsuya Sakamoto, Hirotaka Sakamoto

  JOURNAL OF COMPARATIVE NEUROLOGY 525(7) 1586-1598 2017年5月 査読有り
• Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats

  Nao Katayama, Takumi Oti, Keiko Takanami, Tatsuya Sakamoto, Hirotaka Sakamoto

  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 92(2) 69-75 2016年2月 査読有り筆頭著者
• Perinatal testosterone exposure is critical for the development of the male-specific sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that mediates erection and ejaculation

  Takumi Oti, Keiko Takanami, Nao Katayama, Tomoca Edey, Keita Satoh, Tatsuya Sakamoto, Hirotaka Sakamoto

  BIOLOGY OF SEX DIFFERENCES 7 4 2016年1月 査読有り筆頭著者