小林 武彦

論文

• sic1 mutation leads to rDNA instability by partial duplication with SIR4

  Taichi Murai, Shuichi Yanagi, Yutaro Hori, Yoshio Yamamuro, Takehiko Kobayashi

  Nucleic Acids Research 54(4) 2026年2月5日 査読有り最終著者責任著者
• Structural basis of transcription-coupled H3K36 trimethylation by Set2 in coordination with FACT.

  Tomoya Kujirai, Haruhiko Ehara, Tomoko Ito, Masami Henmi, Eriko Oya, Takehiko Kobayashi, Shun-Ichi Sekine, Hitoshi Kurumizaka

  Science advances 12(5) eaed1952 2026年1月30日
• The histone chaperone CAF-1 prevents homologous recombination-mediated instability of the budding yeast ribosomal DNA during replication-coupled DNA double-strand break repair

  Hajime Futami, Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mio Nagura, Takehiko Kobayashi, Mariko M Sasaki

  Nucleic Acids Research 53(22) 2025年11月26日 査読有り責任著者
• ERC accumulation depletes Sir2 from rDNA and induces cellular senescence by rDNA destabilization

  Yoshio Yamamuro, Yuta Uneme, Sihan Li, Toshifumi Inada, Takehiko Kobayashi

  Nucleic Acids Research 53(20) 2025年10月28日 査読有り最終著者責任著者
• Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes

  Mariko Sasaki, Takehiko Kobayashi

  Nucleic Acids Research 53(3) 2025年1月24日 最終著者責任著者
• Comparative analysis and classification of highly divergent mouse rDNA units based on their intergenic spacer (IGS) variability.

  Jung-Hyun Kim, Ramaiah Nagaraja, Alexey Y Ogurtsov, Vladimir N Noskov, Mikhail Liskovykh, Hee-Sheung Lee, Yutaro Hori, Takehiko Kobayashi, Kent Hunter, David Schlessinger …

  NAR genomics and bioinformatics 6(2) lqae070 2024年6月
• Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site

  Takuro Shioi, Suguru Hatazawa, Eriko Oya, Noriko Hosoya, Wataru Kobayashi, Mitsuo Ogasawara, Takehiko Kobayashi, Yoshimasa Takizawa, Hitoshi Kurumizaka

  Nature 628(8006) 212-220 2024年3月20日
• Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast.

  Taichi Murai, Shuichi Yanagi, Yutaro Hori, Takehiko Kobayashi

  iScience 27(3) 109120-109120 2024年3月15日
• The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster

  Junno Ohira, Mariko Sasaki, Takehiko Kobayashi

  2024年3月14日
• The histone chaperone CAF-1 maintains the stability of the ribosomal RNA gene cluster by suppressing end resection of replication-associated DNA double-strand breaks

  Hajime Futami, Mariko Sasaki, Takehiko Kobayashi

  2024年3月12日
• 4.5SH RNA counteracts deleterious exonization of SINE B1 in mice

  Rei Yoshimoto, Yuta Nakayama, Ikuko Nomura, Ikuko Yamamoto, Yumeka Nakagawa, Shigeyuki Tanaka, Misuzu Kurihara, Yu Suzuki, Takehiko Kobayashi, Hiroko Kozuka-Hata …

  Molecular Cell 83(24) 4479-4493.e6 2023年12月
• Acidic growth conditions stabilize the ribosomal RNA gene cluster and extend lifespan through non-coding transcription repression

  Yo Hasegawa, Hiroyuki Ooka, Tsuyoshi Wakatsuki, Mariko Sasaki, Ayumi Yamamoto, Takehiko Kobayashi

  Genes to Cells 2023年12月 査読有り
• Changed life course upon defective replication of ribosomal RNA genes.

  Mei Hattori, Chihiro Horigome, Théo Aspert, Gilles Charvin, Takehiko Kobayashi

  Genes & genetic systems 97(6) 285-295 2023年4月18日
• Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes.

  Yutaro Hori, Christoph Engel, Takehiko Kobayashi

  Nature reviews. Molecular cell biology 2023年2月2日
• RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster.

  Shuichi Yanagi, Tetsushi Iida, Takehiko Kobayashi

  Molecular and cellular biology e0002822 2022年4月6日
• Regulatory processes that maintain or alter ribosomal DNA stability during the repair of programmed DNA double-strand breaks

  Mariko Sasaki, Takehiko Kobayashi

  Genes & Genetic Systems 2022年
• The human ribosomal DNA array is composed of highly homogenized tandem clusters.

  Yutaro Hori, Akira Shimamoto, Takehiko Kobayashi

  Genome research 2021年8月18日
• Evaluation of repair activity by quantification of ribonucleotides in the genome.

  Tetsushi Iida, Naoko Iida, Jun Sese, Takehiko Kobayashi

  Genes to cells : devoted to molecular & cellular mechanisms 2021年5月15日
• Establishment of an "in yeast" experimental system

  Iida,T, Kobayashi,T

  Genes & Genetic Systems 2021年5月 査読有り最終著者責任著者
• The S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA

  Goto, M, Sasaki, M, Kobayashi, T

  Mol Cell Biol 41(5) 2021年4月22日 査読有り最終著者責任著者