中別府 雄作

論文

• An N‐terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice

  Sayaka Okuzono, Fumihiko Fujii, Daiki Setoyama, Ryoji Taira, Yohei Shinmyo, Hiroki Kato, Keiji Masuda, Kousuke Yonemoto, Satoshi Akamine, Yuki Matsushita …

  Genes to Cells 2024年7月4日
• Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice.

  Mizuki Ohno, Noriko Takano, Kyoko Hidaka, Fumiko Sasaki, Kazumi Yamauchi, Yasunobu Aoki, Takehiko Nohmi, Yusaku Nakabeppu, Yoshimichi Nakastu, Teruhisa Tsuzuki

  Genome research 2024年1月30日
• ヒトMTH1の幅広い基質認識におけるAsp残基のプロトン化状態

  中村 照也, 小川 由香里, 藤宮 佳菜, 池鯉鮒 麻美, 後藤 大空, 池水 信二, 中別府 雄作, 山縣 ゆり子

  日本生化学会大会プログラム・講演要旨集 96回 [1P-180] 2023年10月
• APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1.

  Carol E Schrader, Travis Williams, Klaus Pechhold, Erin K Linehan, Daisuke Tsuchimoto, Yusaku Nakabeppu

  Journal of immunology (Baltimore, Md. : 1950) 210(11) 1804-1814 2023年6月1日
• Protonation states of Asp residues in the human Nudix hydrolase <scp>MTH1</scp> contribute to its broad substrate recognition

  Teruya Nakamura, Yukari Koga‐Ogawa, Kana Fujimiya, Mami Chirifu, Masataka Goto, Shinji Ikemizu, Yusaku Nakabeppu, Yuriko Yamagata

  FEBS Letters 2023年3月13日
• Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer’s disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior

  Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Takashi Saito, Takaomi C. Saido, Ryo Yamasaki, Jun-ichi Kira, Yusaku Nakabeppu

  Neuroscience Research 177 118-134 2022年4月 査読有り最終著者責任著者
• Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin

  Kazuya Matsuo, Yasuharu Shinoda, Nona Abolhassani, Yusaku Nakabeppu, Kohji Fukunaga

  Frontiers in Psychiatry 13 2022年3月30日 査読有り
• Mutyh deficiency downregulates mitochondrial fusion proteins and causes cardiac dysfunction via α-ketoglutaric acid reduction with oxidative stress

  Jingwen Chen, Xin Wu, Yanyi Wang, Yunfeng Pan, Yan Ren, Yusaku Nakabeppu, Yimei Fan, Yaping Wang

  Free Radical Research 2022年 査読有り責任著者
• 8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Exacerbates Doxorubicin-Induced Cardiac Dysfunction

  Chukwuemeka George Anene-Nzelu, Peter Yiqing Li, Tuan Danh Anh Luu, Shi Ling Ng, Zenia Tiang, Bangfen Pan, Wilson Lek Wen Tan, Matthew Ackers-Johnson, Ching Kit Chen, Yee Phong Lim …

  Oxidative Medicine and Cellular Longevity 2022 2022年 査読有り責任著者
• APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

  Md Akram Hossain, Yunfeng Lin, Garrett Driscoll, Jia Li, Anne McMahon, Joshua Matos, Haichao Zhao, Daisuke Tsuchimoto, Yusaku Nakabeppu, Jianjun Zhao …

  Frontiers in Cell and Developmental Biology 9 2021年11月2日 査読有り
• Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.

  Erika Castillo, Julio Leon, Guianfranco Mazzei, Nona Abolhassani, Naoki Haruyama, Takashi Saito, Takaomi Saido, Masaaki Hokama, Toru Iwaki, Tomoyuki Ohara …

  Scientific reports 11(1) 18377-18377 2021年9月9日
• A high-fat diet exacerbates the Alzheimer’s disease pathology in the hippocampus of the App_NL-F/NL-F knock-in mouse model.

  Mazzei G, Ikegami R, Abolhassani N, Haruyama N, Sakumi K, Saito T, Saido TC, Nakabeppu Y

  Aging Cell 20(8) e13429 2021年7月 査読有り
• Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer

  Nakamura T, Okabe K, Hirayama S, Chirifu M, Ikemizu S, Morioka H, Nakabeppu Y, Yamagata Y

  Nucleic Acids Res 2021年6月 査読有り
• MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

  Oka, S., Leon, J., Sakumi, K., Abolhassani, N., Sheng, Z. …

  Sci Rep 11(1) 5819-5819 2021年3月 査読有り
• MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model

  Sakamoto, H., Miyanishi, K., Tanaka, S., Ito, R., Hamaguchi, K. …

  Sci Rep 11(1) 2021年2月 査読有り
• Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury

  Hu, Y., Yang, C., Amorim, T., Maqbool, M., Lin, J. …

  Cancer Res 81(3) 713-723 2021年2月 査読有り
• MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease

  Yuri Mizuno, Nona Abolhassani, Guianfranco Mazzei, Kunihiko Sakumi, Takashi Saito, Takaomi C. Saido, Toshiharu Ninomiya, Toru Iwaki, Ryo Yamasaki, Jun Ichi Kira …

  Oxidative Medicine and Cellular Longevity 2021 2021年 査読有り最終著者責任著者
• Serum Anti-oligodendrocyte Autoantibodies in Patients With Multiple Sclerosis Detected by a Tissue-Based Immunofluorescence Assay.

  Yukino Miyachi, Takayuki Fujii, Ryo Yamasaki, Daisuke Tsuchimoto, Kyoko Iinuma, Ayako Sakoda, Shoko Fukumoto, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe …

  Frontiers in neurology 12 681980-681980 2021年
• GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons

  Akamine, S., S. Okuzono, H. Yamamoto, D. Setoyama, N. Sagata, M. Ohgidani, T. A. Kato, T. Ishitani, H. Kato …

  FASEB J 2020年11月 査読有り
• Neural stem cell-specific Itpa deficiency causes neural depolarization and epilepsy

  Koga, Y., Tsuchimoto, D., Hayashi, Y., Abolhassani, N., Yoneshima, Y. …

  JCI Insight 5(22) e140229 2020年11月 査読有り