大野 行弘

論文

• In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

  Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita

  British Journal of Pharmacology 2026年4月8日
• Contrasting effects of PHD finger protein 24 (PHF24) on brain morphology of the spontaneous generalized tonic-clonic seizure model; Noda epileptic rat (NER) and <i>Phf24</i>-null rat

  Yuki NUMAKURA, Miyuu TANAKA, Takeshi IZAWA, Jyoji YAMATE, Takashi KURAMOTO, Tadao SERIKAWA, Naofumi KUNISAWA, Saki SHIMIZU, Yukihiro OHNO, Mitsuru KUWAMURA

  Experimental Animals 2026年2月
• Ameliorative effects of Kir4.1 channel inhibitors on lipopolysaccharide-induced cognitive impairment via BDNF/TrkB signaling pathway

  Ishizaki Y., Shimizu S., Kusaka A., Yoshida A., Kunisawa N., Ohno Y.

  J. Pharmacol. Sci. 159(2) 64-73 2025年10月 査読有り責任著者
• Imbalance of glutamatergic and GABAergic neurotransmission in audiogenic seizure-susceptible Leucine-rich glioma-inactivated 1 (Lgi1)-mutant rats

  Masato Kinboshi, Saki Shimizu, Kentaro Tokudome, Tomoji Mashimo, Tadao Serikawa, Hidefumi Ito, Ryosuke Takahashi, Akio Ikeda, Yukihiro Ohno

  Heliyon 9(7) e17984-e17984 2023年7月 査読有り責任著者
• Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor

  Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Higor A. Iha, Yukihiro Ohno

  Frontiers in Pharmacology 13 2022年6月16日 査読有り最終著者責任著者
• Emerging Roles of Astrocyte Kir4.1 Channels in the Pathogenesis and Treatment of Brain Diseases

  Yukihiro Ohno, Naofumi Kunisawa, Saki Shimizu

  International Journal of Molecular Sciences 22(19) 10236-10236 2021年9月23日 査読有り招待有り筆頭著者責任著者
• Perisynaptic astrocytes as a potential target for novel antidepressant drugs

  Marcos E. Frizzo, Yukihiro Ohno

  Journal of Pharmacological Sciences 145 60-68 2021年1月 査読有り招待有り最終著者
• Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis

  Masato Kinboshi, Akio Ikeda, Yukihiro Ohno

  Frontiers in Neurology 11 626658-626658 2020年12月23日 査読有り責任著者
• Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility

  Yoneko Hayase, Shigeru Amano, Koichi Hashizume, Takashi Tominaga, Hiroyuki Miyamoto, Yukie Kanno, Yukiko Ueno-Inoue, Takayoshi Inoue, Mayumi Yamada, Shigehiro Ogata …

  Acta Neuropathologica Communications 8(1) 206-206 2020年12月 査読有り
• Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats.

  Ai Nishitani, Haruna Nagayoshi, Shigeo Takenaka, Masahide Asano, Saki Shimizu, Yukihiro Ohno, Takashi Kuramoto

  Experimental animals 69(4) 388-394 2020年6月5日 査読有り
• Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats.

  Tadao Serikawa, Naofumi Kunisawa, Saki Shimizu, Masaki Kato, Higor Alves Iha, Masato Kinboshi, Hisao Nishikawa, Yu Shirakawa, Birger Voigt, Satoshi Nakanishi …

  Behavioural brain research 369 111922-111922 2019年9月2日 査読有り
• Antipsychotic Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD): Management of Extrapyramidal Side Effects.

  Ohno Y, Kunisawa N, Shimizu S

  Frontiers in pharmacology 10 1045 2019年9月 査読有り
• Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor.

  Iha HA, Kunisawa N, Shimizu S, Onishi M, Nomura Y, Matsubara N, Iwai C, Ogawa M, Hashimura M, Sato K …

  Neurotoxicity research 35(3) 575-583 2019年4月 査読有り
• Loss of HCN1 subunits causes absence epilepsy in rats.

  Nishitani A, Kunisawa N, Sugimura T, Sato K, Yoshida Y, Suzuki T, Sakuma T, Yamamoto T, Asano M, Saito Y …

  Brain research 1706 209-217 2019年3月 査読有り
• Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.

  Masato Kinboshi, Saki Shimizu, Tomoji Mashimo, Tadao Serikawa, Hidefumi Ito, Akio Ikeda, Ryosuke Takahashi, Yukihiro Ohno

  International journal of molecular sciences 20(5) E1013 2019年2月26日 査読有り
• Inwardly Rectifying Potassium Channel Kir4.1 as a Novel Modulator of BDNF Expression in Astrocytes.

  Ohno Y, Kinboshi M, Shimizu S

  International journal of molecular sciences 19(11) 2018年10月 査読有り
• Astrocytic Kir4.1 potassium channels as a novel therapeutic target for epilepsy and mood disorders

  Yukihiro Ohno

  Neural Regeneration Research 13(4) 651-652 2018年4月1日 査読有り
• Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region.

  Mukai T, Kinboshi M, Nagao Y, Shimizu S, Ono A, Sakagami Y, Okuda A, Fujimoto M, Ito H, Ikeda A …

  Frontiers in pharmacology 9 845 2018年 査読有り
• Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents

  Naofumi Kunisawa, Saki Shimizu, Masaki Kato, Higor A. Iha, Chihiro Iwai, Mai Hashimura, Mizuki Ogawa, Shohei Kawaji, Kazuma Kawakita, Keisuke Abe …

  Journal of Pharmacological Sciences 137(2) 162-169 2018年 査読有り
• 312

  Inhibition of Inwardly Rectifying Potassium (Kir) 4.1 Channels Facilitates Brain-Derived Neurotrophic Factor (BDNF) Expression in Astrocytes

  Masato Kinboshi, Takahiro Mukai, Yuki Nagao, Yusuke Matsuba, Yoshimi Tsuji, Shiho Tanaka, Kentaro Tokudome, Saki Shimizu, Hidefumi Ito, Akio Ikeda …

  FRONTIERS IN MOLECULAR NEUROSCIENCE 10 408 2017年12月 査読有り