宮野 雅司

論文

• Na⁺イオンをミミックするリガンドはロイコトリエンB₄受容体BLT1の不活性化状態を安定化する

  Tetsuya Hori, Toshiaki Okuno, Knio Hirata, Keitaro Yamashita, Yoshiaki Kawano, Masaki Yamamoto, Masakatsu Hato, Motonao Nakamura, Takao Shimizu, Takehiko Yokomizo …

  Nature Chemical Biology 14(3) 262-269 2018年3月 査読有り
• The Y54(L)W mutation of anti-leukotriene C₄ single-chain antibody increases affinity to leukotriene E₄

  J. Biochem. 161 79-86 2017年 査読有り
• Novel Features of Eukaryotic Photosystem II Revealed by Its Crystal Structure Analysis from a Red Alga.

  J. Biol. Chem. 291 5676-5687 2016年3月 査読有り
• SBDD:タンパク質構造解析による薬剤設計のはじまりから現在 特集 革新的創薬開発と実用化

  宮野雅司

  化学工業 66(12) 933-940 2015年12月 招待有り
• The leukotriene B₄ receptor BLT1 is stabilized by transmembrane helix capping mutations

  Biochemistry and Biophysics Reports 4 243-249 2015年12月 査読有り
• Crystal Structure of OXA-58 with the Substrate-Binding Cleft in a Closed State: Insights into the Mobility and Stability of the OXA-58 Structure.

  PLOS ONE 10 e0145869 2015年12月 査読有り
• Neutralization of leukotriene C-4 and D-4 activity by monoclonal and single-chain antibodies

  Yuki Kawakami, Shiori Hirano, Mai Kinoshita, Akemi Otsuki, Toshiko Suzuki-Yamamoto, Makiko Suzuki, Masumi Kimoto, Sae Sasabe, Mitsuo Fukushima, Koji Kishimoto …

  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1840(6) 1625-1633 2014年6月 査読有り
• A leukotoriene C4 synthase inhibitor with the backbone of 5-(5-metylene-4-oxo-4,5-dihydrothiazole-2-ylamino)isophthalic acid

  J Biochemistry 153 421-429 2013年 査読有り
• The catalyric architecture of leukotriene C4 synthase with two arginine residues.

  J Biol Chem 16392-16401 2011年 査読有り
• Seleno-detergent MAD phasing of leukotriene C4synthase in complex with dodecyl-selenomaltoside.

  Acta Crystal. F. 1666-1673 2011年 査読有り
• The catalytic efficiency (k(cat)/K-m) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog

  Yasushi Nitanai, Tatsuro Shimamura, Takuro Uchiyama, Yoshikazu Ishii, Michiyo Takehira, Katsuhide Yutani, Hiroshi Matsuzawa, Masashi Miyano

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1804(4) 684-691 2010年4月 査読有り
• Internally bridging water molecule in transmembrane alpha-helical kink.

  Curr Opin Struct Biol 456-463 2010年 査読有り
• Functional expression of single-chain antibody to leukotriene C4.

  Biochem Biophys Res Commun. 421-425 2010年 査読有り
• Expression, purification and characterization of leukotriene B4 receptor, BLT1 in Pichia pastoris.

  Protein Expr Purif. 2010年 査読有り
• Structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase.

  J Biol Chem 22344-22352 2009年 査読有り
• Crystallization and preliminary diffraction studies of prostaglandin E2-specific monoclonal antibody Fab fragment in the ligand complex.

  Acta Crystallogr Sect F 1027-1030 2008年 査読有り
• Application of maximum-entropy maps in the accurate refinement of a putative acylphosphatase using 1.3 A X-ray diffraction data.

  Acta Crystallogr D 237-247 2008年 査読有り
• RVCaB, a calcium-binding protein in radish vacuoles, is predominantly an unstructured protein with a polyproline type II helix.

  J Biochem 201-211 2007年 査読有り
• Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.

  Nature 609-612 2007年 査読有り
• Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus.

  J Biol Chem 16157-16167 2006年 査読有り