山崎 浩史

論文

• Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species

  Yasuhiro Uno, Koya Fukunaga, Hiroshi Yamazaki

  Biochemical pharmacology 2026年11月
• In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: a comparison with humans, monkeys, and dogs

  Chizuka Sakai, Eriko Higashi, Shunsuke Iwano, Yohei Miyamoto, Hiroshi Yamazaki, Masashi Uchida

  Xenobiotica 2026年8月5日
• Different roles of canine cytochrome p450 2C and 3A enzymes involved in the oxidative metabolism of phenobarbital, a key anticonvulsant for dogs: Comparison with human p450 enzymes

  Yasuhiro Uno, Koya Fukunaga, Norie Murayama, Taisei Mushiroda, Makiko Shimizu, Hiroshi Yamazaki

  Journal of veterinary pharmacology and therapeutics 2026年7月6日
• Biphasic dextromethorphan O-demethylation in tree shrews mediated by liver microsomal cytochromes P450 with high and low affinities

  Genki Ushirozako, Atsushi Asano, Konosuke Otomaru, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno

  Drug metabolism and disposition 2026年6月
• Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide.

  Yasuhiro Uno, Koya Fukunaga, Makiko Shimizu, Genki Ushirozako, Keijiro Mizukami, Tomomi Aoi, Hirotaka Tomiyasu, Muneki Honnami, Hajime Tsujimoto, Masahiro Sakaguchi …

  Biochemical pharmacology 247 117790-117790 2026年5月
• Tyrosine kinase inhibitors suppress cytochrome P450 2C8 and 2J2 functions and their expression in renal cell carcinoma

  Ayaka Kojima, Masayuki Nadai, Hiroshi Yamazaki, Miki Katoh

  Drug metabolism and pharmacokinetics 2026年5月
• Baseline variations in in vivo cytochrome P450 3A-dependent phenotypes evaluated using concentrations of endogenous or deuterium-labeled cortisol and their 6β-hydroxylated metabolites in 103 cynomolgus monkeys and 20 humanized-liver mice transplanted with hepatocytes

  Shotaro Uehara, Yuichiro Higuchi, Suguru Fukuda, Makiko Shimizu, Akihito Shimoi, Hiroshi Suemizu, Hiroshi Yamazaki

  Drug metabolism and disposition 2026年5月
• Humanized-liver TK-NOG mice lacking plasma carboxylesterase 1c improve the prediction of human carboxylesterase 1-mediated drug metabolism

  Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Motohito Goto, Masafumi Yamamoto, Misa Mochizuki, Riichi Takahashi, Masahiko Yasuda, Hiroshi Yamazaki, Hiroshi Suemizu

  Drug metabolism and disposition 2026年4月
• Novel cytochrome P450 2J isoforms in tree shrews are functional drug-metabolising enzymes involved in ebastine and astemizole oxidation

  Yasuhiro Uno, Miu Kamizono, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Norie Murayama, Hiroshi Yamazaki

  Xenobiotica 2026年1月2日
• Virtual internal exposures of lansoprazole administered to cytochrome P450 2C19 poor metabolizers estimated by simplified physiologically based pharmacokinetic modeling.

  Makiko Shimizu, Koichiro Adachi, Yukia Shimura, Katsuhiro Ohyama, Yoichi Tanaka, Yoshiro Saito, Hiroshi Yamazaki

  The Journal of toxicological sciences 51(6) 349-356 2026年
• Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole

  Yasuhiro Uno, Koya Fukunaga, Genki Ushirozako, Norie Murayama, Keijiro Mizukami, Tomomi Aoi, Hirotaka Tomiyasu, Muneki Honnami, Hajime Tsujimoto, Masahiro Sakaguchi …

  Biochemical pharmacology 242 117394-117394 2025年12月
• Prediction of human hepatic clearance with HepaSH monolayers for low-turnover compounds

  Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu

  Drug metabolism and disposition 2025年12月
• Tyrosine kinase inhibitors, nilotinib and radotinib, suppress both catalytic function and mRNA expression of human cytochrome P450 2J2 and 2C8

  Ayaka Kojima, Masayuki Nadai, Hiroshi Yamazaki, Miki Katoh

  Drug metabolism and pharmacokinetics 2025年12月
• Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations

  Yasuhiro Uno, Genki Ushirozako, Norie Murayama, Hiroshi Yamazaki

  Biochemical pharmacology 2025年12月
• Genetic variants in dog cytochrome P450 2B6 and their relevance to inter-individual variability of oxidations of probe drug propofol

  Yasuhiro Uno, Koya Fukunaga, Genki Ushirozako, Norie Murayama, Keijiro Mizukami, Tomomi Aoi, Hirotaka Tomiyasu, Muneki Honnami, Hajime Tsujimoto, Masahiro Sakaguchi …

  Drug metabolism and disposition 100189-100189 2025年10月
• Japanese medicinal drug labeling for use in the clinical setting as informed by pharmacogenomic data on cytochrome P450 enzymes obtained from in silico studies

  Yoichi Tanaka, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki

  Drug metabolism and pharmacokinetics 2025年10月
• Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs

  Makiko Shimizu, Anna Nii, Yasuhiro Uno, Hiroshi Yamazaki

  Drug metabolism and disposition 2025年9月
• Virtual hepatic and plasma exposures of voriconazole administered to cytochrome p450 2C19 poor metabolizers predicted by simplified and full pharmacokinetic modeling systems: Possible causal factor for hepatic disorders seen in a japanese database

  Koichiro Adachi, Katsuhiro Ohyama, Yukia Shimura, Yoichi Tanaka, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki

  Biological and pharmaceutical bulletin 48(8) 1271-1276 2025年8月29日
• Virtual hepatic and plasma exposures of voriconazole administered to cytochrome p450 2C19 poor metabolizers predicted by simplified and full pharmacokinetic modeling systems: Possible causal factor for hepatic disorders seen in a japanese database

  Adachi Koichiro, Ohyama Katsuhiro, Shimura Yukia, Tanaka Yoichi, Shimizu Makiko, Saito Yoshiro, Yamazaki Hiroshi

  Biological and pharmaceutical bulletin 48(8) 1271-1276 2025年8月29日
• Prediction of internal exposures after virtual oral doses of disparate chemicals in rats and humans using simplified physiologically based pharmacokinetic models with in silico-generated input parameters

  Hiroshi Yamazaki, Makiko Shimizu

  Chemical research in toxicology 2025年7月21日