大庭 賢二

論文

• A post-inflammatory C3-high astrocyte state persists after inflammatory stimulus withdrawal and is attenuated by JAK inhibition

  Yogo Sakakibara, Kyohei Okahara, Jungo Kakuta, Kazumi Emoto, Yuri Ofusa, Kenji Ohba

  bioRxiv 2026年5月28日 最終著者責任著者
• YY1 Binding Motif Upstream of Rep/Cap Increases AAV Yield and Full Capsids

  Yuri Ofusa, Sanae Nishio, Tatsuji Enoki, Junichi Mineno, Keiya Ozawa, Hiroaki Mizukami, Kenji Ohba

  2026年5月22日
• Heterogeneous Sensitivity to Src Inhibitors in Oral Squamous Cell Carcinoma and Its Implications for Combination Therapy with Cisplatin

  Yuri Ofusa, Tadahide Noguchi, Hiroaki Mizukami, Kenji Ohba

  bioRxiv 2026年4月6日 最終著者責任著者
• Limitation of Assay Sensitivity Revealed by the Improvement of Cell-Based Assay Against Various Adeno-Associated Virus Serotypes

  Ryota Watano, Kenji Ohba, Yoshihide Sehara, Yuka Hayashi, Yasushi Saga, Masashi Urabe, Tsukasa Ohmori, Hiroaki Mizukami

  Human Gene Therapy 36(11-12) 914-924 2025年6月1日
• Comparative aptamer profiling reveals cell surface remodeling and the emergence of a noncanonical cell surface protein under oncogenic signaling

  Jungo Kakuta, Kenji Ohba, Hideaki Ogasawara, Kyohei Okahara, Kazumi Emoto, Hiroaki Sako, Miho Sekai, Yasuyuki Fujita, Toshio Imai, Yogo Sakakibara

  RSC Chemical Biology 6(12) 1941-1949 2025年
• Adeno-associated Virus-mediated Ezh2 Knockdown Reduced the Increment of Newborn Neurons Induced by Forebrain Ischemia in Gerbil Dentate Gyrus

  Yoshihide Sehara, Yuki Hashimotodani, Ryota Watano, Kenji Ohba, Ryosuke Uchibori, Kuniko Shimazaki, Kensuke Kawai, Hiroaki Mizukami

  Molecular Neurobiology 61(11) 9623-9632 2024年4月27日
• Therapeutic Strategy for Fabry Disease by Intravenous Administration of Adeno-Associated Virus 9 in a Symptomatic Mouse Model

  Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi, Yoshio Sakiyama, Kazuhiro Muramatsu, Hiroaki Mizukami

  Human Gene Therapy 35(5-6) 192-201 2024年3月1日
• Protocol for producing an adeno-associated virus vector by controlling capsid expression timing

  Kenji Ohba, Hiroaki Mizukami

  STAR Protocols 4(4) 102542-102542 2023年12月15日 査読有り招待有り筆頭著者責任著者
• Therapeutic strategy for Fabry disease by intravenous administration of adeno‐associated virus 2 or 9 in α‐galactosidase A‐deficient mice

  Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi, Kazuhiro Muramatsu, Yoshio Sakiyama, Hiroaki Mizukami

  The Journal of Gene Medicine e3560 2023年6月30日 査読有り
• Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality

  Kenji Ohba, Yoshihide Sehara, Tatsuji Enoki, Junichi Mineno, Keiya Ozawa, Hiroaki Mizukami

  iScience 26(4) 106487-106487 2023年3月 査読有り筆頭著者責任著者
• Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction

  Shiyu Ayukawa, Nagisa Kamoshita, Jun Nakayama, Ryohei Teramoto, Novalia Pishesha, Kenji Ohba, Nanami Sato, Kei Kozawa, Hikari Abe, Kentaro Semba …

  Nature Immunology 22(11) 1391-1402 2021年11月 査読有り
• Higher Transduction Efficiency of AAV5 to Neural Stem Cells and Immature Neurons in Gerbil Dentate Gyrus Compared to AAV2 and rh10

  Yoshihide Sehara, Yuka Hayashi, Kenji Ohba, Ryosuke Uchibori, Masashi Urabe, Ayumu Inutsuka, Kuniko Shimazaki, Kensuke Kawai, Hiroaki Mizukami

  Human Gene Therapy 33(1-2) 76-85 2021年9月15日 査読有り
• The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia

  Kei Kozawa, Miho Sekai, Kenji Ohba, Shoko Ito, Hiroaki Sako, Takeshi Maruyama, Mai Kakeno, Takanobu Shirai, Keisuke Kuromiya, Tomoko Kamasaki …

  Current Biology 31(14) 3086-3097.e7 2021年7月 査読有り
• Cooperative Orthogonal Macromolecular Assemblies with Broad Spectrum Antiviral Activity, High Selectivity, and Resistance Mitigation

  Koji Ichiyama, Chuan Yang, Lakshmi Chandrasekaran, Shaoqiong Liu, Lijun Rong, Yue Zhao, Shujun Gao, Ashlynn Lee, Kenji Ohba, Youichi Suzuki …

  MACROMOLECULES 49(7) 2618-2629 2016年4月 査読有り
• Macrophage response to oncolytic paramyxoviruses potentiates virus-mediated tumor cell killing

  Darren Qiancheng Tan, LiFeng Zhang, Kenji Ohba, Min Ye, Koji Ichiyama, Naoki Yamamoto

  EUROPEAN JOURNAL OF IMMUNOLOGY 46(4) 919-928 2016年4月 査読有り
• Cancellers - Exploring the Possibility of Receptor Decoy Traps As a Superior Anti-Retroviral Strategy

  Sundararaj Stanley Jeremiah, Kenji Ohba, Naoki Yamamoto

  CURRENT DRUG TARGETS 17(6) 678-692 2016年 査読有り
• Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

  Youichi Suzuki, Wei-Xin Chin, Qi'En Han, Koji Ichiyama, Ching Hua Lee, Zhi Wen Eyo, Hirotaka Ebina, Hirotaka Takahashi, Chikako Takahashi, Beng Hui Tan …

  PLOS PATHOGENS 12(1) e1005357 2016年1月 査読有り
• Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia

  Li Feng Zhang, Darren Qian Cheng Tan, Anand D. Jeyasekharan, Wen Son Hsieh, Anh Son Ho, Koji Ichiyama, Min Ye, Brendan Pang, Kenji Ohba, Xin Liu …

  CANCER LETTERS 354(2) 272-280 2014年11月 査読有り
• In Vivo and In Vitro Studies Suggest a Possible Involvement of HPV Infection in the Early Stage of Breast Carcinogenesis via APOBEC3B Induction

  Kenji Ohba, Koji Ichiyama, Misako Yajima, Nobuhiro Gemma, Masaru Nikaido, Qingqing Wu, PeiPei Chong, Seiichiro Mori, Rain Yamamoto, John Eu Li Wong …

  PLOS ONE 9(5) e97787 2014年5月 査読有り筆頭著者
• Studies of designer zinc finger enzymes and applications for genome editing and modification

  Wataru Nomura, Akemi Masuda, Asami Kondo, Kenji Ohba, Naoki Yamamoto, Akihide Ryo, Hirokazu Tamamura

  PROTEIN SCIENCE 21 215-215 2012年8月 査読有り