萩原 宏毅

論文

• Effects of inactivity and exercise intervention on brain-derived neurotrophic factor in mice: Comparison of kinetics in serum, skeletal muscle, and brain.

  Azusa Miki, Masahiro Aihara, Hikaru Kawaguchi, Noboru Hirose, Hiroki Hagiwara

  Biomedical research (Tokyo, Japan) 45(4) 163-172 2024年 査読有り
• Circulating α-Klotho Counteracts Transforming Growth Factor-β-Induced Sarcopenia.

  Yutaka Ohsawa, Hideaki Ohtsubo, Asami Munekane, Kohei Ohkubo, Tatsufumi Murakami, Masahiro Fujino, Shin-Ichiro Nishimatsu, Hiroki Hagiwara, Hirotake Nishimura, Ryuki Kaneko …

  The American journal of pathology 193(5) 591-607 2023年5月 査読有り
• Caveolin 3 suppresses phosphorylation-dependent activation of sarcolemmal nNOS

  Yutaka Ohsawa, Hideaki Ohtsubo, Yoshihiko Saito, Shinichiro Nishimatsu, Hiroki Hagiwara, Tatsufumi Murakami, Ichizo Nishino, Yoshihide Sunada

  Biochemical and Biophysical Research Communications 2022年8月 査読有り
• 機能性食品HMB摂取が老齢マウスの脳由来神経栄養因子BDNFに与える影響

  三樹あずさ, 相原正博, 萩原宏毅

  理学療法やまなし 1(1) 14-20 2022年1月 査読有り
• Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach.

  Miki Ikeda, Mariko Taniguchi-Ikeda, Takema Kato, Yasuko Shinkai, Sonoko Tanaka, Hiroki Hagiwara, Naomichi Sasaki, Toshihiro Masaki, Kiichiro Matsumura, Masahiro Sonoo …

  Molecular therapy. Methods & clinical development 18 131-144 2020年9月11日 査読有り
• Taurine supplementation for prevention of stroke-like episodes in MELAS: A multicentre, open-label, 52-week phase III trial

  Yutaka Ohsawa, Hiroki Hagiwara, Shin-Ichiro Nishimatsu, Akihiro Hirakawa, Naomi Kamimura, Hideaki Ohtsubo, Yuta Fukai, Tatsufumi Murakami, Yasutoshi Koga, Yu-Ichi Goto …

  Journal of Neurology, Neurosurgery and Psychiatry 2018年4月19日 査読有り
• Changes in oxidative stress severity and antioxidant potential during muscle atrophy and reloading in mice

  Wakana Katsuta, Masahiro Aihara, Noboru Hirose, Fumiaki Saito, Hiroki Hagiwara

  Journal of Physical Therapy Science 30(1) 42-46 2018年 査読有り
• Cleavage of β-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9.

  Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu SI, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y

  Biochemical and biophysical research communications 492(2) 199-205 2017年10月 査読有り
• Redundancy of matrix metalloproteinases cleaving beta-dystroglycan: Implications for the pathogenesis of sarcoglycanopathy

  Yuta Fukai, Yutaka Ohsawa, Hideaki Ohtsubo, Shin-ichiro Nishimatsu, Hiroki Hagiwara, Makoto Noda, Toshikuni Sasaoka, Tatsufumi Murakami, Yoshihide Sunada

  Biochem. Biophys. Res. Comm. 492(2) 199-205 2017年8月15日 査読有り
• Pax3 preserves myoblasts undifferentiated by suppressing MyoD and enhancing cell cycle regulators

  Shan Huang, Hiroki Hagiwara, Teruo Shimizu, Weizhi Wang

  INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 10(3) 3043-3051 2017年 査読有り
• A new model of skeletal muscle atrophy induced by immobilization using a hook-and-loop fastener in mice

  Masahiro Aihara, Noboru Hirose, Wakana Katsuta, Fumiaki Saito, Hitoshi Maruyama, Hiroki Hagiwara

  Journal of Physical Therapy Science 29(10) 1779-1783 2017年 査読有り
• The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy

  Yutaka Ohsawa, Kentaro Takayama, Shin-ichiro Nishimatsu, Tadashi Okada, Masahiro Fujino, Yuta Fukai, Tatsufumi Murakami, Hiroki Hagiwara, Fumiko Itoh, Kunihiro Tsuchida …

  PLOS ONE 10(7) e0133713 2015年7月 査読有り
• Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice

  Fumiaki Saito, Motoi Kanagawa, Miki Ikeda, Hiroki Hagiwara, Toshihiro Masaki, Hidehiko Ohkuma, Yuki Katanosaka, Teruo Shimizu, Masahiro Sonoo, Tatsushi Toda …

  HUMAN MOLECULAR GENETICS 23(17) 4543-4558 2014年9月 査読有り
• Biglycan Is an Extracellular MuSK Binding Protein Important for Synapse Stability

  Alison R. Amenta, Hilliary E. Creely, Mary Lynn T. Mercado, Hiroki Hagiwara, Beth A. McKechnie, Beatrice E. Lechner, Susana G. Rossi, Qiang Wang, Rick T. Owens, Emilio Marrero …

  JOURNAL OF NEUROSCIENCE 32(7) 2324-2334 2012年2月 査読有り
• Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors

  Hiroki Hagiwara, Fumiaki Saito, Toshihiro Masaki, Miki Ikeda, Ayami Nakamura-Ohkuma, Teruo Shimizu, Kiichiro Matsumura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 414(4) 826-831 2011年11月 査読有り
• Secretion of N-terminal domain of α-dystroglycan in cerebrospinal fluid.

  Saito F, Saito-Arai Y, Nakamura-Okuma A, Ikeda M, Hagiwara H, Masaki T, Shimizu T, Matsumura K

  Biochemical and biophysical research communications 411(2) 365-369 2011年7月 査読有り
• Dystroglycan, A Multifunctional Adaptor Protein for Signal Transduction and A Potential Therapeutic Target

  Hiroki Hagiwara, Kiichiro Matsumura

  CURRENT SIGNAL TRANSDUCTION THERAPY 6(1) 71-81 2011年1月 査読有り
• Congenital muscular dystrophy and α-dystroglycanopathy

  Fumiaki Saito, Kiichiro Matsumura, Hiroki Hagiwara, Teruo Shimizu

  Clinical Neurology 48(8) 543-549 2008年 査読有り
• Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development

  Michael S. Rafii, Hiroki Hagiwara, Mary Lynn Mercado, Neung S. Seo, Tianshun Xu, Tracey Dugan, Rick T. Owens, Magnus Hook, David J. McQuillan, Marian F. Young …

  JOURNAL OF CELLULAR PHYSIOLOGY 209(2) 439-447 2006年11月 査読有り
• Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition

  Yutaka Ohsawa, Hiroki Hagiwara, Masashi Nakatani, Akihiro Yasue, Keiji Moriyama, Tatsufumi Murakami, Kunihiro Tsuchida, Sumihare Noji, Yoshihide Sunada

  JOURNAL OF CLINICAL INVESTIGATION 116(11) 2924-2934 2006年11月 査読有り