萩原 英雄

論文

• Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures

  Markos Michail Chatzigiannis, Hideo Hagihara, Tsuyoshi Miyakawa

  Neuropsychopharmacology Reports 46(3) e70150 2026年9月 査読有り責任著者
• Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming.

  Tomoyuki Murano, Hideo Hagihara, Katsunori Tajinda, Keizo Takao, Yoshihiro Takamiya, Kaoru Katoh, Alfred J Robison, Mitsuyuki Matsumoto, Masakazu Namihira, Tsuyoshi Miyakawa

  Nature Communications 17(1) 5881 2026年7月17日 査読有り
• Increased Cerebrospinal Fluid Lactate Levels in Schizophrenia and Major Depressive Disorder: NCNP Biobank Study in Japan

  Hideo Hagihara, Kotaro Hattori, Hiroshi Kunugi, Tsuyoshi Miyakawa

  Neuropsychopharmacology Reports 46(1) e70096 2026年3月3日 査読有り責任著者
• Hyper-maturity and accelerated aging in the hippocampus of mouse models of neuropsychiatric disorders with anxiety-like behavior

  Hideo Hagihara, Hisatsugu Koshimizu, Satoko Hattori, Hirotaka Shoji, Miho Tanaka, Kazutaka Ikeda, Tsuyoshi Miyakawa

  Neuropsychopharmacology 51(5) 856-867 2025年10月27日 査読有り責任著者
• Chronic Hyponatremia Potentiates Innate Anxiety-Like Behaviors Through the Dysfunction of Monoaminergic Neurons in Mice

  Haruki Fujisawa, Nobuhiko Magara, Shogo Nakayama, Sachiho Fuse, Naoko Iwata, Masaya Hasegawa, Hisayoshi Kubota, Hirotaka Shoji, Satoko Hattori, Hideo Hagihara …

  Molecular Neurobiology 62(9) 12078-12093 2025年9月 査読有り
• Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype

  Hirotaka Shoji, Hideo Hagihara, Isabella A Graef, Gerald R Crabtree, Freesia L Huang, Paul W Frankland, Tsuyoshi Miyakawa

  International Journal of Neuropsychopharmacology 28(10) pyaf062 2025年8月23日 査読有り
• Gene Expression Signatures of Immaturity, Decreased pH, and Neural Hyperexcitation in the Hippocampus of Alzheimer's Disease Model Mice

  Sayaka Naganishi, Hideo Hagihara, Tsuyoshi Miyakawa

  Neuropsychopharmacology Reports 45(1) e70001 2025年3月 査読有り責任著者
• Postmortem evidence of decreased brain pH in major depressive disorder: a systematic review and meta-analysis

  Hideo Hagihara, Tsuyoshi Miyakawa

  Translational Psychiatry 14 460 2024年11月4日 査読有り責任著者
• Decreased brain pH correlated with progression of Alzheimer disease neuropathology: a systematic review and meta-analyses of postmortem studies

  Hideo Hagihara, Tsuyoshi Miyakawa

  International Journal of Neuropsychopharmacology 27(10) pyae047 2024年10月18日 査読有り責任著者
• Decreased brain pH correlated with progression of Alzheimer’s disease neuropathology: a systematic review and meta-analyses of postmortem studies

  Hideo Hagihara, Tsuyoshi Miyakawa

  medRxiv 2024年04月30日.24306603 2024年5月2日 責任著者
• Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

  Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori …

  eLife 12 RP89376 2024年3月26日 査読有り責任著者
• Effect of brain acidification on depression-related behaviors in diabetes mellitus

  Yusuke Temma, Kisho Obi-Nagata, Yoshio Hoshiba, Ryuhei Miyake, Yuta Katayama, Hideo Hagihara, Norimitsu Suzuki, Tsuyoshi Miyakawa, Keiichi I. Nakayama, Akiko Hayashi-Takagi

  Frontiers in Psychiatry 14 1277097 2023年11月29日 査読有り
• Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

  Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori …

  bioRxiv 2021年02月02日.428362 2023年11月6日 責任著者
• Metabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress

  Katsutaka Oishi, Yuhei Yajima, Yuta Yoshida, Hideo Hagihara, Tsuyoshi Miyakawa, Sayaka Higo-Yamamoto, Atsushi Toyoda

  Scientific Reports 13(1) 11156 2023年7月10日 査読有り
• The gene expression patterns as surrogate indices of pH in the brain

  Hideo Hagihara, Tomoyuki Murano, Tsuyoshi Miyakawa

  Frontiers in Psychiatry 14 1151480 2023年5月2日 査読有り責任著者
• Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice

  Hideo Hagihara, Hirotaka Shoji, Mahomi Kuroiwa, Isabella A Graef, Gerald R Crabtree, Akinori Nishi, Tsuyoshi Miyakawa

  Molecular Brain 15(1) 94-94 2022年11月22日 査読有り
• Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioral phenotype

  Masayoshi Nagai, Kenji Iemura, Takako Kikkawa, Sharmin Naher, Satoko Hattori, Hideo Hagihara, Koh ichi Nagata, Hayato Anzawa, Risa Kugisaki, Hideki Wanibuchi …

  Brain Communications 4(5) fcac220 2022年8月30日 査読有り
• Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

  Daiki X Sato, Yukiko U Inoue, Nahoko Kuga, Satoko Hattori, Kensaku Nomoto, Yuki Morimoto, Giovanni Sala, Hideo Hagihara, Takefumi Kikusui, Takuya Sasaki …

  iScience 25(8) 104800 2022年8月19日 査読有り
• Exposure to GABAA Receptor Antagonist Picrotoxin in Pregnant Mice Causes Autism-Like Behaviors and Aberrant Gene Expression in Offspring

  Hiroko Kotajima-Murakami, Hideo Hagihara, Atsushi Sato, Yoko Hagino, Miho Tanaka, Yoshihisa Katoh, Yasumasa Nishito, Yukio Takamatsu, Shigeo Uchino, Tsuyoshi Miyakawa …

  Frontiers in Psychiatry 13 821354 2022年2月3日 査読有り
• Protein lactylation induced by neural excitation

  Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Kaoru Katoh, Masakazu Namihira, Tsuyoshi Miyakawa

  Cell Reports 37(2) 109820 2021年10月12日 査読有り