安田 大輔

論文

• KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation

  Keijiro Komeda, Kai Toyoshima, Daisuke Yasuda, Hanako Ishida, Koujin Kojima, Masanori Osawa, Tomoya Hirano, Tomoyuki Ohe, Kenji Tago, Megumi Funakoshi-Tago

  Cellular Signalling 137 112194 2026年 査読有り
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  Development of Keap1-Nrf2 Protein-protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2-acetamide Scaffold, and its Anti-inflammatory Effects

  Daisuke Yasuda, Kai Toyoshima, Koujin Kojima, Hanako Ishida, Kazuma Kaitoh, Riyo Imamura, Kayoko Kanamitsu, Hirotatsu Kojima, Megumi Funakoshi-Tago, Masanori Osawa …

  ChemMedChem 20(21) e202500474 2025年8月22日 査読有り筆頭著者責任著者
• Ropinirole Functions Through a Dopamine Receptor D2‐Independent Mechanism to Ameliorate Amyotrophic Lateral Sclerosis Phenotypes in TARDBP‐Mutant iPSC‐Derived Motor Neurons

  Hirotsugu Asano, Tetsuya Kawaguchi, Chris Kato, Satoru Morimoto, Masato Yano, Maki Minaguchi, Daisuke Yasuda, Komei Fukushima, Hideyuki Okano

  Journal of Neurochemistry 169(8) e70183 2025年8月18日 査読有り
• Development of Fluorescent Estrogen Receptor Ligands with pH Sensor Functionality

  Tomoya Hirano, Daisuke Yasuda, Takeshi Yamada, Hiroyuki Kagechika

  Chemical and Pharmaceutical Bulletin 73(4) 412-418 2025年4月29日 査読有り
• Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease

  Daiki Katagishi, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino, Tomoyuki Ohe

  Bioorganic and Medicinal Chemistry Letters 80 129121-129121 2023年1月 査読有り
• Development of p62-Keap1 Protein-Protein Interaction Inhibitors as Doxorubicin-Sensitizers Against Non-Small Cell Lung Cancer

  Daisuke Yasuda, Ippei Yoshida, Riyo Imamura, Daiki Katagishi, Kyoko Takahashi, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Tadahiko Mashino …

  Results in Chemistry 4 100609 2022年10月 査読有り筆頭著者責任著者
• Synthesis and Evaluation of Nevirapine Analogs to Study the Metabolic Activation of Nevirapine

  Yasuhiro Tateishi, Tomoyuki Ohe, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Yasuhiro Kazuki, Tadahiko Mashino

  Drug Metabolism and Pharmacokinetics 35(2) 238-243 2020年2月 査読有り
• Ropinirole, a New ALS Drug Candidate Developed Using iPSCs.

  Hideyuki Okano, Daisuke Yasuda, Koki Fujimori, Satoru Morimoto, Shinichi Takahashi

  Trends in Pharmacological Sciences 41(2) 99-109 2020年2月 査読有り
• Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line

  Yasuda D., Ohe T., Takahashi, K., Imamura, R., Kojima H., Okabe T., Ichimura Y., Komatsu M., Yamamoto M., Nagano T. …

  Free Radical Research 54(11-12) 859-871 2020年 査読有り筆頭著者
• Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.

  Tomoyuki Ohe, Ryutaro Umezawa, Yumina Kitagawara, Daisuke Yasuda, Kyoko Takahashi, Shigeo Nakamura, Akiko Abe, Shuichi Sekine, Kousei Ito, Kentaro Okunushi …

  Bioorganic & medicinal chemistry letters 28(23-24) 3708-3711 2018年12月15日 査読有り
• A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis.

  Tomomi Niino, Kenji Tago, Daisuke Yasuda, Kyoko Takahashi, Tadahiko Mashino, Hiroomi Tamura, Megumi Funakoshi-Tago

  Biochemical pharmacology 155 182-197 2018年9月 査読有り
• アカデミアにおける Hit-to-Lead の実践 ~Keap1-Nrf2 タンパク間相互作用阻害剤の創製~

  安田大輔, 小畠りか, 高橋恭子, 大江知之, 増野匡彦

  薬学雑誌 138 1059-1065 2018年8月1日 査読有り招待有り
• Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

  Daisuke Yasuda, Akihiro Yuasa, Rika Obata, Mao Nakajima, Kyoko Takahashi, Tomoyuki Ohe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Riyo Imamura …

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(22) 5006-5009 2017年11月 査読有り筆頭著者
• Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

  Daisuke Yasuda, Mao Nakajima, Akihiro Yuasa, Rika Obata, Kyoko Takahashi, Tomoyuki Ohe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Riyo Imamura …

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26(24) 5956-5959 2016年12月 査読有り筆頭著者
• Development of Novel Inhibitors for Keap1-Nrf2 and Keap1-P62 Protein-Protein Interaction

  Daisuke Yasuda, Akihiro Yuasa, Mao Nakajima, Taketo Yoshida, Rika Obata, Kyoko Takahashi, Tomoyuki Ohe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto …

  FREE RADICAL BIOLOGY AND MEDICINE 100 S76-S76 2016年11月 査読有り筆頭著者
• Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives

  Daisuke Yasuda, Kyoko Takahashi, Tomoyuki Ohe, Shigeo Nakamura, Tadahiko Mashino

  JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 59(3) 165-173 2016年11月 査読有り筆頭著者
• p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

  Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi …

  NATURE COMMUNICATIONS 7 12030 2016年6月 査読有り
• 尿酸のラジカル消去機構を規範とした新規抗酸化活性医薬品リード化合物の創製研究

  安田 大輔

  2014年3月31日 査読有り
• Antioxidant activities of 5-hydroxyoxindole and its 3-hydroxy-3-phenacyl derivatives: The suppression of lipid peroxidation and intracellular oxidative stress

  Daisuke Yasuda, Kyoko Takahashi, Tomoyuki Ohe, Shigeo Nakamura, Tadahiko Mashino

  BIOORGANIC & MEDICINAL CHEMISTRY 21(24) 7709-7714 2013年12月 査読有り筆頭著者
• Synthesis, radical scavenging activity and structure–activity relationship of uric acid analogs

  YASUDA Daisuke, TAKAHASHI kyoko, KAKINOKI Tomohiro, TANAKA Yoko, OHE Tomoyuki, NAKAMURA Shigeo, MASHINO Tadahiko

  Med. Chem. Commun. 4(3) 527-529 2013年3月 査読有り筆頭著者