Kaoru Tominaga

Profile Information

Affiliation

School of Medicine, Jichi Medical University

Degree

博士(医学)(Mar, 1994, 自治医科大学)

J-GLOBAL ID

201401018168107794

researchmap Member ID

B000237522

External link

http://kaken.nii.ac.jp/d/r/20265242.ja.html

Research Interests

• mitochondria
• senescence
• metabolism
• Epigenetics
• cancer
• aging
• histone modification
• stem cell
• chromatin
• cellular senescence
• リポ多糖
• C3H
• MAPキナーゼ
• IL-6
• マクロファージ
• HeJマウス
• 線維芽細胞
• NF-κB
• 感染防御
• スカベンジャー受容体
• LPS(リポ多糖)
• ノックアウトマウス

Research Areas

• Life sciences / Nutrition and health science / Aging, senescence
• Life sciences / Functional biochemistry / metabolism
• Life sciences / Neuroscience - general / neural stem cell
• Life sciences / Molecular biology / epigenetic, chromatin
• Life sciences / Genomics /
• Life sciences / Laboratory animal science /
• Life sciences / Tumor biology /
• Life sciences / Cell biology /
• Life sciences / Medical biochemistry /

Research History

• Apr, 2022 - Present

  Professor, School of Medicine, Department of Biochemistry, Division of Structural Biochemistry, Jichi Medical University
• Oct, 2020 - Mar, 2022

  Professor, Division of Functional Biochemistry, Department of Biochemistry, School of Medicine, Jichi Medical University
• Apr, 2011 - Sep, 2020

  School of Medicine, Jichi Medical University

Papers

• The Natural Quassinoid Brusatol Enhances Venetoclax Efficacy and Overcomes Resistance in Myeloid Leukemias

  Shin‐ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Ken Suzaki, Susumu Goyama, Chiyoko Kato, Eiji Sakashita, Kaoru Tominaga …

  Cancer Science, May 21, 2026 Peer-reviewed
• ピルビン酸脱水素酵素欠損症iPS細胞を用いた病態代謝特性の検討

  阿部 朋行, 坂下 英司, 黒岩 憲二, 笠嶋 克巳, 猪木 泰, 田口 由起, 太田 恵理子, 加藤 千代子, 宮林 重明, 冨永 薫 …

  日本生化学会大会プログラム・講演要旨集, 98回 1P-430, Nov, 2025
• ピルビン酸脱水素酵素欠損症iPS細胞を用いた病態代謝特性の検討

  阿部 朋行, 坂下 英司, 黒岩 憲二, 笠嶋 克巳, 猪木 泰, 田口 由起, 太田 恵理子, 加藤 千代子, 宮林 重明, 冨永 薫 …

  日本生化学会大会プログラム・講演要旨集, 98回 3T15-02, Nov, 2025
• STK38 Kinase Promotes Cell Migration Induced by Oncogenic Ras via MerTK Activation

  Satoshi Ohta, Kenji Tago, Katsumi Kasashima, Masayuki Ebina, Kaoru Tominaga

  International Journal of Molecular Sciences, 26(21) 10388-10388, Oct 25, 2025 Peer-reviewedLast authorCorresponding author
• The combination of venetoclax with dimethyl fumarate synergistically induces apoptosis in AML cells by disrupting mitochondrial integrity through ROS accumulation

  Shin-ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Kaoru Tominaga, Hitoshi Endo, Tom Kouki, Nobuhiko Ohno, Yoshinobu Kanda

  Cell Death & Disease, 16(1), Oct 21, 2025 Peer-reviewed
• Dimethyl Fumarate Negatively Regulates MYC Signaling and Promotes Cell‐Cycle Arrest in T‐Cells through a GSH‐Dependent Mechanism

  Kazuya Sato, Shin‐ichiro Kawaguchi, Junko Izawa, Takashi Ikeda, Kiyomi Mashima, Norihito Takayama, Hiroko Hayakawa, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda

  European Journal of Immunology, 55(4), Apr 19, 2025 Peer-reviewed
• Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease.

  Hirofumi Nakano, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Takashi Ikeda, Shin-Ichiro Kawaguchi, Kiyomi Mashima, Kento Umino, Kaoru Morita …

  ImmunoHorizons, 8(3) 228-241, Mar 1, 2024 Peer-reviewed
• Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells

  Kaoru Tominaga, Eiji Sakashita, Katsumi Kasashima, Kenji Kuroiwa, Yasumitsu Nagao, Naoki Iwamori, Hitoshi Endo

  International Journal of Molecular Sciences, 24(3) 2113-2113, Jan 20, 2023 Peer-reviewedLead authorCorresponding author
• κB-Ras結合タンパク質TRB3は新規のがん抑制シグナル分子として機能する

  多胡 憲治, 杉山 直幸, 太田 聡, 大村 千尋, 松儀 実広, 柳澤 健, 冨永 薫, 伊東 広, 多胡 めぐみ

  日本生化学会大会プログラム・講演要旨集, 95回 2T12a-05, Nov, 2022
• Dimethyl fumarate ameliorates graft‐versus‐host disease by inhibiting T‐cell metabolism and immune responses through a reactive oxygen species‐dependent mechanism

  Kiyomi Mashima, Kazuya Sato, Takashi Ikeda, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Shin‐Ichiro Kawaguchi, Hirofumi Nakano, Takashi Nagayama, Kento Umino …

  British Journal of Haematology, Feb 15, 2022 Peer-reviewed
• Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo

  Rintaro Kuroda, Kaoru Tominaga, Katsumi Kasashima, Kenji Kuroiwa, Eiji Sakashita, Hiroko Hayakawa, Tom Kouki, Nobuhiko Ohno, Kensuke Kawai, Hitoshi Endo

  PLOS ONE, 16(7) e0255355-e0255355, Jul 28, 2021 Peer-reviewedCorresponding author
• Mesenchymal Stromal Cells Inhibit Aerobic Glycolysis in Activated T Cells by Negatively Regulating Hexokinase II Activity Through PD-1/PD-L1 Interaction

  Yasufumi Kawasaki, Kazuya Sato, Kiyomi Mashima, Hirofumi Nakano, Takashi Ikeda, Kento Umino, Kaoru Morita, Junko Izawa, Norihito Takayama, Hiroko Hayakawa …

  TRANSPLANTATION AND CELLULAR THERAPY, 27(3), Mar, 2021 Peer-reviewed
• Comprehensive Metabolomic Analysis of IDH1R132H Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency.

  Satsuki Miyata, Kaoru Tominaga, Eiji Sakashita, Masashi Urabe, Yoshiyuki Onuki, Akira Gomi, Takashi Yamaguchi, Makiko Mieno, Hiroaki Mizukami, Akihiro Kume …

  Scientific reports, 9(1) 9787-9787, Jul 5, 2019 Peer-reviewedCorresponding author
• MRG15 is required for pre-mRNA splicing and spermatogenesis.

  Naoki Iwamori, Kaoru Tominaga, Tetsuya Sato, Kevin Riehle, Tokuko Iwamori, Yasuyuki Ohkawa, Cristian Coarfa, Etsuro Ono, Martin M Matzuk

  Proceedings of the National Academy of Sciences of the United States of America, 113(37) E5408-15, Sep 13, 2016 Peer-reviewed
• Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates.

  Mashiko T, Sakashita E, Kasashima K, Tominaga K, Kuroiwa K, Nozaki Y, Matsuura T, Hamamoto T, Endo H

  The Journal of biological chemistry, 291(29) 14996-15007, Jul, 2016 Peer-reviewed
• 発生段階特異的RNA結合蛋白質Drb1の細胞質封入体形成機構の解析

  益子 貴史, 坂下 英司, 笠嶋 克巳, 黒岩 憲二, 冨永 薫, 松浦 徹, 遠藤 仁司

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [3P1250]-[3P1250], Dec, 2015
• The emerging role of senescent cells in tissue homeostasis and pathophysiology.

  Kaoru Tominaga

  Pathobiology of aging & age related diseases, 5 27743-27743, 2015 Peer-reviewedLead authorLast authorCorresponding author
• Rapid selection of XO embryonic stem cells using Y chromosome-linked GFP transgenic mice

  Satoshi Yamamoto, Yasumitsu Nagao, Kenji Kuroiwa, Yoji Hakamata, Masaru Ichida, Fumiko Saito-Ohara, Kaoru Tominaga, Hitoshi Endo

  TRANSGENIC RESEARCH, 23(5) 757-765, Oct, 2014 Peer-reviewed
• Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type

  Syuichi Tetsuka, Kaoru Tominaga, Eriko Ohta, Kenji Kuroiwa, Eiji Sakashita, Katsumi Kasashima, Toshiro Hamamoto, Michito Namekawa, Mitsuya Morita, Shinsuke Natsui …

  JOURNAL OF THE NEUROLOGICAL SCIENCES, 335(1-2) 48-57, Dec, 2013 Peer-reviewed
• Paraneoplastic cerebellar degeneration with bladder cancer confirmed the existence of an anti-neural antibody: A case report

  Kotaro Kawanishi, Mitsuya Morita, Keiichi Nakahara, Syuichi Tetsuka, Tom Kouki, Kaoru Tominaga, Hitoshi Endo, Takashi Yashiro, Keiko Tanaka, Imaharu Nakano

  Brain and Nerve, 65(11) 1401-1405, Nov, 2013 Peer-reviewed

Misc.

• TP53 activation by the natural quassinoid brusatol enhances venetoclax efficacy and overcomes resistance in myeloid leukemias

  Shin-ichiro Kawaguchi, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Chiyoko Kato, Eiji Sakashita, Kaoru Tominaga, Hitoshi Endo, Yoshinobu Kanda

  BLOOD, 146 1491-1492, Nov 3, 2025
• ピルビン酸脱水素酵素欠損症iPS細胞の樹立と大脳オルガノイドの作製

  阿部朋行, 坂下英司, 黒岩憲二, 笠嶋克巳, 猪木泰, 太田恵理子, 加藤千代子, 宮林重明, 冨永薫, 遠藤仁司

  日本生化学会大会(Web), 97th, 2024
• 疾患iPS細胞によるピルビン酸脱水素酵素欠損症の病態モデリングの試み

  阿部朋行, 坂下英司, 黒岩憲二, 笠嶋克巳, 猪木泰, 太田恵理子, 加藤千代子, 宮林重明, 冨永薫, 遠藤仁司

  日本分子生物学会年会プログラム・要旨集(Web), 47th, 2024
• Ras発がんシグナルにおける新規がん抑制遺伝子産物RGS16の機能解析

  大多和 宏季, 大村 千尋, 太田 聡, 松儀 実広, 多胡 めぐみ, 富永 薫, 多胡 憲治

  日本生化学会大会プログラム・講演要旨集, 95回 2T12a-08, Nov, 2022
• 微小環境を用いた再樹立法による多能性幹細胞の高品質化

  長尾恭光, 冨永薫, 坂下英司, 阿部朋行, 秋本千鶴, 花園豊, 遠藤仁司

  日本生化学会大会(Web), 90th ROMBUNNO.3P‐0857 (WEB ONLY)-0857], Dec, 2017
• Mrg15 is required in premigratory neural crest cells for postnatal morphogenesis of the skull

  Meizhen Chen, Kaoru Tominaga, Jungmi Ahn, Michael Foret, Naoki Iwamori, Martin M. Matzuk, Paul R. Mueller, Gary O. Gaufo

  AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 167(7) 1465-1465, Jul, 2015
• 傍腫瘍性小脳変性症(PCD)の新規抗原(brain-type creatine kinase;CKB)の同定

  手塚 修一, 黒岩 憲二, 滑川 道人, 森田 光哉, 冨永 薫, 田中 惠子, 瀧山 嘉久, 遠藤 仁司, 中野 今治

  臨床神経学, 53(12) 1541-1541, Dec, 2013
• Paraneoplastic cerebellar degeneration with bladder cancer confirmed the existence of an anti-neural antibody: A case report

  Kotaro Kawanishi, Mitsuya Morita, Keiichi Nakahara, Syuichi Tetsuka, Tom Kouki, Kaoru Tominaga, Hitoshi Endo, Takashi Yashiro, Keiko Tanaka, Imaharu Nakano

  Brain and Nerve, 65(11) 1401-1405, Nov, 2013
• Paraneoplasticcerebellar Degeneration Associated with an Onconeural Antibody Against Creatine Kinase, Brain-Type

  Syuichi Tetsuka, Kaoru Tominaga, Kenji Kuroiwa, Mitsuya Morita, Hitoshi Endo

  ANNALS OF NEUROLOGY, 74 S87-S87, Oct, 2013
• 傍腫瘍性小脳変性症(PCD)の新規抗原(brain‐type creatine kinase;CKB)の同定

  手塚修一, 黒岩憲二, 滑川道人, 森田光哉, 冨永薫, 田中惠子, 瀧山嘉久, 遠藤仁司, 中野今治

  日本神経学会学術大会プログラム・抄録集, 54th 430, 2013
• Activation of innate immune antiviral responses by Nod2 (vol 10, pg 1073, 2009)

  Ahmed Sabbah, Te Hung Chang, Rosalinda Harnack, Victoria Frohlich, Kaoru Tominaga, Peter H. Dube, Yan Xiang, Santanu Bose

  NATURE IMMUNOLOGY, 11(10) 969-969, Oct, 2010
• Do Thioredoxin 2 Transgenic and Thioredoxin 1 Knockout Mice Extend Lifespan through Different Mechanisms?

  Lisa A. Cortez, Celeste R. Webb, Megan Mahlke, Arunabh Bhattacharya, Wenbo Qi, Yiqiang Zhang, Yuhong Liu, Shuko Lee, Holly VanRenunen, Arlan Richardson …

  FREE RADICAL BIOLOGY AND MEDICINE, 49 S80-S81, 2010
• 疾患と遺伝子異常(2)Chk1欠損マウスを用いたマウスChk1キナーゼの機能解析

  高井裕之, 冨永薫, 本山昇, 池田恭治, 中西真, 永浜裕康, 中山啓子, 中山敬一

  日本臨床分子医学会記録, 37 (70), Nov 7, 2000
• Chk1キナーゼ欠損マウスを用いたマウスChk1キナーゼの機能解析

  高井裕之, 冨永薫, 本山昇, 池田恭治, 中西真, 永浜裕康, 中山啓子, 中山敬一

  日本分子生物学会年会プログラム・講演要旨集, 22nd 261, Nov 22, 1999
• Cds1キナーゼはp53経路を相補するDNAチェックポイント機構を制御する

  李 勝範, 富永 薫, 森崎 弘史, 大坪 素秋, 佐々木 實, 岡山 博人, 池田 恭治, 中西 真

  生化学, 71(8) 1043-1043, Aug, 1999
• Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-κB cascades, but not lipopolysaccharide-incorporation・・・

  TOMINAGA K, SAITO S, MATSUURA M, NAKANO M

  Biochemica et Biophysica Acta, 1450(2) 130-144, 1999
• ヒトChk1キナーゼの構造及び機能解析

  藤本淳司, 冨永薫, 池田恭治, 中西真

  日本分子生物学会年会プログラム・講演要旨集, 21st 492, Nov, 1998
• Potent prostaglandin A(1) analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. (vol 273, pg 18522, 1998)

  M Tanikawa, K Yamada, K Tominaga, H Morisaki, Y Kaneko, K Ikeda, M Suzuki, T Kiho, K Tomokiyo, K Furuta …

  JOURNAL OF BIOLOGICAL CHEMISTRY, 273(38) 24978-24978, Sep, 1998
• Infant mitochondrial disease. Features of mitochondrial gene.

  TOMINAGA KAORU

  小児内科, 30(9) 1113-1117, Sep, 1998
• Cell Cycle Control on Cellular Senescence.

  TOMINAGA KAORU, NAKANISHI MAKOTO

  細胞工学, 17(9) 1363-1367, Sep, 1998

Research Projects

• Investigation of mitochondrial function leading to fate decision of neural stem cells and establishment of functional brain

  Apr, 2025 - Mar, 2028

  Kaoru Tominaga
• Targeting mitochondrial fatty acid transportation as novel therapy for Bcl-2 inhibitor resistant leukemia

  Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
• Investigation of chromatin regulation network for fate decision of neural stem cells and establishment of functional brain structure

  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024

  Kaoru Tomimaga
• The role of epigenetic regulator in neural stem cell maintenance and differentiation

  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

  Tominaga Kaoru
• Mechanism of neural stem cell maintenance by chromatin regulator

  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2016

  TOMINAGA KAORU
• THE ROLE OF SCAVENGER RECEPTORS ON MURINE MACROPHAGES AGAINST INFECTION

  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1996 - 1996

  NAKANO Masyasu, TOMINAGA Kaoru, KIRIKAE Teruo, KII Michisato
• リポ多糖(LPS)によるマウスマクロファージ及び線維芽細胞の活性比に関する研究

  科学研究費助成事業 奨励研究(A), 奨励研究(A), 日本学術振興会, 1996 - 1996

  冨永 薫
• リポ多糖(LPS)低応答性C3H/HeJマウス由来細胞株の樹立

  科学研究費助成事業 奨励研究(A), 奨励研究(A), 日本学術振興会, 1995 - 1995

  富永 薫