石原 宏

論文

• The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells.

  Masafumi Nakamoto, Ko Ishihara, Takehisa Watanabe, Akiyuki Hirosue, Shinjiro Hino, Masanori Shinohara, Hideki Nakayama, Mitsuyoshi Nakao

  PloS one 12(1) e0169225 2017年
• DNA methylation-independent removable insulator controls chromatin remodeling at the HOXA locus via retinoic acid signaling.

  Ko Ishihara, Masafumi Nakamoto, Mitsuyoshi Nakao

  Human molecular genetics 25(24) 5383-5394 2016年12月15日
• The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome.

  Yorifumi Satou, Paola Miyazato, Ko Ishihara, Hiroko Yaguchi, Anat Melamed, Michi Miura, Asami Fukuda, Kisato Nosaka, Takehisa Watanabe, Aileen G Rowan …

  Proceedings of the National Academy of Sciences of the United States of America 113(11) 3054-9 2016年3月15日
• HTLV-1 inserts an ectopic CTCF-binding site into the human genome

  Yorifumi Satou, Miyazato Paola, Ko Ishihara, Asami Fukuda, Kisato Nosaka, Takehisa Watanabe, Aileen Rowan, Mitsuyoshi Nakao, Charles R. M. Bangham

  RETROVIROLOGY 12 2015年8月28日
• STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.

  Keisuke Wagatsuma, Shizue Tani-ichi, Bingfei Liang, Soichiro Shitara, Ko Ishihara, Manabu Abe, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Masanobu Nanno …

  Journal of immunology (Baltimore, Md. : 1950) 195(4) 1804-14 2015年8月15日
• Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells.

  Akiyuki Hirosue, Ko Ishihara, Kazuaki Tokunaga, Takehisa Watanabe, Noriko Saitoh, Masafumi Nakamoto, Tamir Chandra, Masashi Narita, Masanori Shinohara, Mitsuyoshi Nakao

  Aging cell 11(3) 553-6 2012年6月
• Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells.

  Takehisa Watanabe, Ko Ishihara, Akiyuki Hirosue, Sugiko Watanabe, Shinjiro Hino, Hidenori Ojima, Yae Kanai, Yutaka Sasaki, Mitsuyoshi Nakao

  Molecular and cellular biology 32(8) 1529-41 2012年4月
• Quantitative assessment of higher-order chromatin structure of the INK4/ARF focus in reprogrammed human cells

  Akiyuki Hirosue, Hideki Nakayama, Ko Ishihara, Masafumi Nakamoto, Masashi Nagata, Kenta Kawahara, Ryoji Yoshida, Mitsuyoshi Nakao, Masanori Shinohara

  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 30 S35-S35 2012年
• Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster.

  Tsuyoshi Mishiro, Ko Ishihara, Shinjiro Hino, Shuichi Tsutsumi, Hiroyuki Aburatani, Katsuhiko Shirahige, Yoshikazu Kinoshita, Mitsuyoshi Nakao

  The EMBO journal 28(9) 1234-45 2009年5月6日
• MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

  Lifeng Liu, Ko Ishihara, Takaya Ichimura, Naoyuki Fujita, Shinjiro Hino, Saori Tomita, Sugiko Watanabe, Noriko Saitoh, Takaaki Ito, Mitsuyoshi Nakao

  The Journal of biological chemistry 284(8) 5165-74 2009年2月20日
• Cohesin mediates transcriptional insulation by CCCTC-binding factor.

  Kerstin S Wendt, Keisuke Yoshida, Takehiko Itoh, Masashige Bando, Birgit Koch, Erika Schirghuber, Shuichi Tsutsumi, Genta Nagae, Ko Ishihara, Tsuyoshi Mishiro …

  Nature 451(7180) 796-801 2008年2月14日
• Inhibition of DNA binding of Sox2 by the SUMO conjugation.

  Shu Tsuruzoe, Ko Ishihara, Yasuhiro Uchimura, Sugiko Watanabe, Yoko Sekita, Takahiro Aoto, Hisato Saitoh, Yasuhito Yuasa, Hitoshi Niwa, Michio Kawasuji …

  Biochemical and biophysical research communications 351(4) 920-6 2006年12月29日
• CTCF-dependent chromatin insulator is linked to epigenetic remodeling.

  Ko Ishihara, Mitsuo Oshimura, Mitsuyoshi Nakao

  Molecular cell 23(5) 733-42 2006年9月1日
• An evolutionarily conserved putative insulator element near the 3' boundary of the imprinted Igf2/H19 domain.

  Ko Ishihara, Hiroyuki Sasaki

  Human molecular genetics 11(14) 1627-36 2002年7月1日
• Epigenetic mark sequence of the H19 gene in human sperm

  T Hamatani, H Sasaki, K Ishihara, N Hida, T Maruyama, Y Yoshimura, J Hata, A Umezawa

  BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1518(1-2) 137-144 2001年3月19日
• Mechanisms of Igf2/H19 imprinting: DNA methylation, chromatin and long-distance gene regulation

  H Sasaki, K Ishihara, R Kato

  JOURNAL OF BIOCHEMISTRY 127(5) 711-715 2000年5月
• Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting

  K Ishihara, N Hatano, H Furuumi, R Kato, T Iwaki, K Miura, Y Jinno, H Sasaki

  GENOME RESEARCH 10(5) 664-671 2000年5月
• Sequence of a 42-kb mouse region containing the imprinted H19 locus:: identification of a novel muscle-specific transcription unit showing biallelic expression

  K Ishihara, R Kato, H Furuumi, M Zubair, H Sasaki

  MAMMALIAN GENOME 9(9) 775-777 1998年9月