Reactome Pathway Database

Schema > Reaction > Entries

Arachidonate is oxidised to PGG2 by PTGS1 Show undefined attributes

catalystActivity

[CatalystActivity:10094361] prostaglandin-endoperoxide synthase activity of PTGS1 dimer [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10094363

displayName Arachidonate is oxidised to PGG2 by PTGS1

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-RNO-140359] PGG2 is reduced to PGH2 by PTGS1 - Rattus norvegicus

inferredFrom

[Reaction:R-HSA-140355] Arachidonate is oxidised to PGG2 by PTGS1 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Arachidonate is oxidised to PGG2 by PTGS1
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 => prostaglandin G2
Arachidonate oxidised to PGG2

output

[SimpleEntity:R-ALL-140357] PGG2 [endoplasmic reticulum lumen]

precedingEvent

[Reaction:R-RNO-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Rattus norvegicus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-140355

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(precedingEvent)

[Reaction:R-RNO-140359] PGG2 is reduced to PGH2 by PTGS1

(inferredTo)

[Reaction:R-HSA-140355] Arachidonate is oxidised to PGG2 by PTGS1

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